SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FSE'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.91A 3p50A-4rltA:
undetectable		 3p50A-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.92A 3p50B-4rltA:
undetectable		 3p50B-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.92A 3p50C-4rltA:
undetectable		 3p50C-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.92A 3p50D-4rltA:
undetectable		 3p50D-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 126
LEU A 134
TYR A 139
THR A 138
 None
None
None
FSE  A 201 ( 4.0A)
 0.95A 3p50E-4rltA:
undetectable		 3p50E-4rltA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
GLN A  33
GLY B  67
THR B  71
ASP A  35
 FSE  A 201 ( 4.8A)
None
None
None
None
 1.34A 5l5zV-4rltA:
undetectable
5l5zW-4rltA:
undetectable		 5l5zV-4rltA:
21.27
5l5zW-4rltA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
GLN A  33
GLY B  67
THR B  71
ASP A  35
 FSE  A 201 ( 4.8A)
None
None
None
None
 1.25A 5l66H-4rltA:
undetectable
5l66I-4rltA:
undetectable		 5l66H-4rltA:
21.27
5l66I-4rltA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADA
(3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB
(Mycobacterium
tuberculosis) 		5 / 12 THR A  58
GLN A  33
GLY B  67
THR B  71
ASP A  35
 FSE  A 201 ( 4.8A)
None
None
None
None
 1.24A 5l66V-4rltA:
undetectable
5l66W-4rltA:
undetectable		 5l66V-4rltA:
21.27
5l66W-4rltA:
21.57