SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FRU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
GLU A 414
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
GOL  A 502 ( 4.9A)
 0.61A 1agmA-5gooA:
22.1		 1agmA-5gooA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ASP A  54
TYR A 370
GLU A 414
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
GOL  A 502 ( 4.9A)
 1.05A 1agmA-5gooA:
22.1		 1agmA-5gooA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ASP A  54
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
None
 1.09A 1agmA-5gooA:
22.1		 1agmA-5gooA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
GLU A 414
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
GOL  A 502 ( 4.9A)
 0.61A 1agmA-5gooA:
22.1		 1agmA-5gooA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ASP A  54
TYR A 370
GLU A 414
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
GOL  A 502 ( 4.9A)
 1.05A 1agmA-5gooA:
22.1		 1agmA-5gooA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ASP A  54
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
None
 1.09A 1agmA-5gooA:
22.1		 1agmA-5gooA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		4 / 5 ALA A 100
ALA A 121
LYS A 120
GLU A 119
 None
FRU  A 501 (-3.3A)
None
None
 0.82A 1e7cA-5gooA:
undetectable		 1e7cA-5gooA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 LEU A 160
ARG A 172
PHE A 176
GLY A 140
 None
FRU  A1335 (-2.8A)
None
None
 0.87A 1fapB-2x7xA:
undetectable		 1fapB-2x7xA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_1
(GLUCOAMYLASE-471)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 TYR A  47
ASP A  54
GLY A 183
TYR A 370
GLU A 414
 FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
None
FRU  A 501 (-4.8A)
GOL  A 502 ( 4.9A)
 1.29A 1gahA-5gooA:
22.1		 1gahA-5gooA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		5 / 12 HIS A 147
ALA A 137
GLU A 374
ILE A 390
ASP A 282
 FRU  A 601 (-4.0A)
None
FRU  A 601 (-3.1A)
None
FRU  A 601 (-3.1A)
 1.24A 1kxhA-3vssA:
undetectable		 1kxhA-3vssA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		6 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
ASN A 365
TYR A 370
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
None
FRU  A 501 (-4.8A)
 1.19A 1lf9A-5gooA:
24.8		 1lf9A-5gooA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		7 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
ASN A 365
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
None
FRU  A 501 (-4.8A)
None
 1.21A 1lf9B-5gooA:
9.6		 1lf9B-5gooA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1y9g EXO-INULINASE
(Aspergillus
awamori) 		4 / 8 GLY A  71
ASP A 189
THR A 129
ASP A  41
 None
FRU  A 801 (-2.7A)
None
FRU  A 801 (-2.7A)
 0.85A 1m4iA-1y9gA:
undetectable		 1m4iA-1y9gA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 8 GLY A  83
ASP A 179
THR A 140
ASP A  50
 None
FRU  A 600 (-2.5A)
None
FRU  A 600 (-2.8A)
 0.89A 1m4iA-3kf3A:
undetectable		 1m4iA-3kf3A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		5 / 12 THR A 389
GLU A 374
ASP A 112
PHE A 470
ALA A 487
 None
FRU  A 601 (-3.1A)
FRU  A 601 (-3.1A)
None
None
 1.38A 1oltA-3vssA:
undetectable		 1oltA-3vssA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG
(Escherichia
coli) 		4 / 8 TYR A  33
VAL A  24
ARG A 155
HIS A 121
 FRU  A 701 ( 4.0A)
None
FRU  A 701 ( 4.6A)
None
 1.16A 1s3zA-3brqA:
undetectable
1s3zB-3brqA:
undetectable		 1s3zA-3brqA:
19.67
1s3zB-3brqA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		6 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
ASN A 365
TYR A 370
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
None
FRU  A 501 (-4.8A)
 1.16A 1ulvA-5gooA:
28.9		 1ulvA-5gooA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		6 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
None
 1.09A 1ulvA-5gooA:
28.9		 1ulvA-5gooA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1n3p LECTIN PAL
(Pterocarpus
angolensis) 		5 / 12 PRO A 113
GLY A 105
GLY A 104
GLY A 102
GLN A 222
 None
GLC  A 253 ( 3.8A)
None
None
FRU  A 254 (-4.7A)
 1.23A 1wg8A-1n3pA:
undetectable		 1wg8A-1n3pA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 418
ASP A 417
ASN A 414
HIS A 438
ALA A 439
 None
None
None
None
FRU  A 902 ( 3.7A)
 1.03A 2bm9F-3s29A:
undetectable		 2bm9F-3s29A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		6 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
TYR A 370
GLU A 414
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
GOL  A 502 ( 4.9A)
 1.18A 2f6dA-5gooA:
21.7		 2f6dA-5gooA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA995_1
(GLUCOAMYLASE GLU1)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		6 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
None
 1.14A 2f6dA-5gooA:
21.7		 2f6dA-5gooA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 8 PRO A 442
ASP A 472
SER A 458
PHE A 470
 None
None
FRU  A 601 (-2.9A)
None
 1.22A 2p02A-3vssA:
undetectable		 2p02A-3vssA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 7 ILE A 132
PRO A 101
GLY A 516
TRP A 517
 None
None
FRU  A 604 ( 4.7A)
FRU  A 604 (-4.0A)
 1.20A 2pnjB-3vssA:
undetectable		 2pnjB-3vssA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 10 VAL A 179
LEU A  69
LEU A 146
GLY A 133
ALA A 132
 None
None
None
None
FRU  A1415 ( 4.7A)
 1.26A 2xf3A-4d47A:
1.9		 2xf3A-4d47A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1y9g EXO-INULINASE
(Aspergillus
awamori) 		4 / 5 GLN A  57
PHE A  56
LEU A  89
PHE A  93
 FRU  A 801 (-3.6A)
None
None
NAG  A1001 (-3.8A)
 1.49A 3ablC-1y9gA:
undetectable
3ablJ-1y9gA:
undetectable		 3ablC-1y9gA:
20.90
3ablJ-1y9gA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 5 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.15A 3ablC-3kf3A:
undetectable
3ablJ-3kf3A:
undetectable		 3ablC-3kf3A:
19.12
3ablJ-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 8 LEU A 514
THR A 485
VAL A 490
GLY A 516
 FRU  A 604 (-3.7A)
None
None
FRU  A 604 ( 4.7A)
 0.81A 3dcjB-3vssA:
undetectable		 3dcjB-3vssA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.99A 3keeA-3s29A:
undetectable		 3keeA-3s29A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 1.11A 3keeA-3s29A:
undetectable		 3keeA-3s29A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.94A 3keeB-3s29A:
undetectable		 3keeB-3s29A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.94A 3keeC-3s29A:
undetectable		 3keeC-3s29A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.92A 3keeD-3s29A:
undetectable		 3keeD-3s29A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 8 ASP A 282
GLY A 342
ILE A 341
PRO A 362
 FRU  A 601 (-3.1A)
None
None
None
 0.77A 3nu9A-3vssA:
undetectable		 3nu9A-3vssA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		5 / 12 ILE A 108
GLN A  97
HIS A  93
ILE A 394
GLY A 392
 FRU  A3001 ( 4.3A)
FRU  A3001 ( 3.5A)
None
None
None
 0.96A 3ozwB-5fkcA:
undetectable		 3ozwB-5fkcA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		4 / 6 TYR A 307
GLN A 304
ILE A 308
SER A 481
 None
FRU  A 902 (-4.0A)
None
None
 1.12A 3pmzD-3s29A:
undetectable		 3pmzD-3s29A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.94A 3sudA-3s29A:
undetectable		 3sudA-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.85A 3sudC-3s29A:
undetectable		 3sudC-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.90A 3sudD-3s29A:
undetectable		 3sudD-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 1.01A 3sudD-3s29A:
undetectable		 3sudD-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.83A 3sueA-3s29A:
undetectable		 3sueA-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 0.99A 3sueA-3s29A:
undetectable		 3sueA-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.95A 3sueB-3s29A:
undetectable		 3sueB-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 1.02A 3sueB-3s29A:
undetectable		 3sueB-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.89A 3sueC-3s29A:
undetectable		 3sueC-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 1.03A 3sueC-3s29A:
undetectable		 3sueC-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.92A 3sufA-3s29A:
undetectable		 3sufA-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.80A 3sufB-3s29A:
undetectable		 3sufB-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 0.92A 3sufB-3s29A:
undetectable		 3sufB-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 11 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.90A 3sufC-3s29A:
undetectable		 3sufC-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.93A 3sufD-3s29A:
undetectable		 3sufD-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.94A 3sugA-3s29A:
undetectable		 3sugA-3s29A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 120
ARG A 121
ASP A 248
 FRU  A1335 (-2.5A)
FRU  A1335 (-4.1A)
FRU  A1335 (-2.8A)
 0.83A 4fzvA-2x7xA:
undetectable		 4fzvA-2x7xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		3 / 3 LYS A 251
PRO A 252
SER A 253
 None
FRU  A 504 ( 4.6A)
None
 0.36A 4k50I-4rk9A:
undetectable		 4k50I-4rk9A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 SER A 133
GLY A 271
ASP A 270
GLY A 293
 FRU  A   1 (-2.7A)
None
None
None
 1.03A 4koeA-2invA:
undetectable
4koeB-2invA:
undetectable
4koeC-2invA:
undetectable		 4koeA-2invA:
20.73
4koeB-2invA:
20.73
4koeC-2invA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n6v AMYLOSUCRASE
(Neisseria
polysaccharea) 		5 / 12 ILE A  82
LEU A  79
VAL A 181
ALA A 179
SER A 178
 None
None
None
None
FRU  A 707 (-2.7A)
 0.96A 4m11C-5n6vA:
undetectable		 4m11C-5n6vA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5n6v AMYLOSUCRASE
(Neisseria
polysaccharea) 		5 / 12 ILE A  82
LEU A  79
VAL A 181
ALA A 179
SER A 178
 None
None
None
None
FRU  A 707 (-2.7A)
 0.96A 4m11D-5n6vA:
undetectable		 4m11D-5n6vA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 2x7x SENSOR PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 167
PRO A 168
ASN A 136
TYR A 271
 None
FRU  A1335 (-4.4A)
None
FRU  A1335 (-4.2A)
 1.38A 4mf6A-2x7xA:
undetectable		 4mf6A-2x7xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		3 / 3 ARG A 382
HIS A 287
SER A 381
 FRU  A 902 (-4.1A)
FRU  A 902 (-4.0A)
None
 0.94A 4mjwA-3s29A:
2.0
4mjwB-3s29A:
undetectable		 4mjwA-3s29A:
22.13
4mjwB-3s29A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		3 / 3 SER A 381
ARG A 382
HIS A 287
 None
FRU  A 902 (-4.1A)
FRU  A 902 (-4.0A)
 0.98A 4mjwA-3s29A:
2.0
4mjwB-3s29A:
undetectable		 4mjwA-3s29A:
22.13
4mjwB-3s29A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		5 / 10 TYR A 418
ASP A 417
ALA A  55
TYR A  54
GLY A 411
 None
None
FRU  A 603 ( 3.9A)
None
None
 1.35A 4mmdA-3vssA:
undetectable		 4mmdA-3vssA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 5 ASN A 359
PRO A 358
GLY A 360
ASP A 203
 None
None
None
FRU  A1415 (-2.9A)
 1.11A 4n48B-4d47A:
undetectable		 4n48B-4d47A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 8 PRO A 442
ASP A 472
SER A 458
PHE A 470
 None
None
FRU  A 601 (-2.9A)
None
 1.21A 4ndnA-3vssA:
undetectable		 4ndnA-3vssA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		3 / 3 PRO A 361
LEU A 360
HIS A 291
 None
None
FRU  A 603 (-4.3A)
 0.67A 4pevA-3vssA:
undetectable		 4pevA-3vssA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 GLU X  97
ALA X  98
PHE X  99
 None
None
FRU  X 801 (-4.0A)
 0.55A 4v1fA-3rwkX:
undetectable		 4v1fA-3rwkX:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 GLU X  97
ALA X  98
PHE X  99
 None
None
FRU  X 801 (-4.0A)
 0.56A 4v1fC-3rwkX:
undetectable		 4v1fC-3rwkX:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4b1l LEVANASE
(Bacillus
subtilis) 		3 / 3 ALA A 574
TRP A 664
VAL A 663
 FRU  A1678 ( 3.9A)
FRU  A1678 (-4.3A)
None
 0.44A 4w9nC-4b1lA:
undetectable		 4w9nC-4b1lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		4 / 7 ASP A 221
GLY A 332
GLU A 334
SER A 390
 FRU  A3001 ( 2.7A)
None
GLC  A3002 ( 3.0A)
None
 0.92A 4z53A-5fkcA:
undetectable
4z53B-5fkcA:
undetectable		 4z53A-5fkcA:
23.48
4z53B-5fkcA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME
(Bacillus
licheniformis) 		5 / 10 PHE A 234
LEU A 248
ILE A 247
SER A 188
ALA A 192
 None
None
None
None
FRU  A 504 ( 4.6A)
 1.44A 4z69I-4rk9A:
undetectable		 4z69I-4rk9A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		5 / 11 SER A 458
ILE A 390
THR A 389
TYR A 457
LEU A 135
 FRU  A 601 (-2.9A)
None
None
FRU  A 601 (-4.8A)
None
 1.27A 5albH-3vssA:
0.1		 5albH-3vssA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		5 / 11 SER A 353
ILE A 303
THR A 302
TYR A 352
LEU A  69
 FRU  A1415 ( 4.7A)
None
None
GLC  A1416 (-4.0A)
None
 1.45A 5albH-4d47A:
0.0		 5albH-4d47A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 SER A 133
GLY A 271
ASP A 270
GLY A 293
 FRU  A   1 (-2.7A)
None
None
None
 0.88A 5cdnA-2invA:
undetectable
5cdnB-2invA:
undetectable		 5cdnA-2invA:
22.49
5cdnB-2invA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 SER A 133
GLY A 271
ASP A 270
GLY A 293
 FRU  A   1 (-2.7A)
None
None
None
 0.89A 5cdnR-2invA:
undetectable
5cdnS-2invA:
undetectable		 5cdnR-2invA:
22.49
5cdnS-2invA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		4 / 6 SER A 390
ASP A 221
GLY A 332
GLU A 334
 None
FRU  A3001 ( 2.7A)
None
GLC  A3002 ( 3.0A)
 0.97A 5cdqA-5fkcA:
undetectable
5cdqC-5fkcA:
undetectable
5cdqD-5fkcA:
undetectable		 5cdqA-5fkcA:
23.73
5cdqC-5fkcA:
23.73
5cdqD-5fkcA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		5 / 12 ALA A 112
PRO A  81
THR A 304
GLY A 147
THR A 163
 None
None
FRU  A3001 ( 4.9A)
None
None
 1.15A 5hfjB-5fkcA:
undetectable		 5hfjB-5fkcA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		5 / 12 ALA A 112
PRO A  81
THR A 304
GLY A 147
THR A 163
 None
None
FRU  A3001 ( 4.9A)
None
None
 1.12A 5hfjH-5fkcA:
undetectable		 5hfjH-5fkcA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		3 / 3 ASP A 282
ASN A 279
PHE A 388
 FRU  A 601 (-3.1A)
None
None
 0.86A 5jglB-3vssA:
undetectable		 5jglB-3vssA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		3 / 3 ASP A 203
ASN A 200
PHE A 301
 FRU  A1415 (-2.9A)
None
None
 0.76A 5jglB-4d47A:
undetectable		 5jglB-4d47A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 7 GLY A 380
ALA A  71
ASP A  46
PHE A 365
 None
None
FRU  A1415 (-2.9A)
None
 0.98A 5mvsA-4d47A:
undetectable		 5mvsA-4d47A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4d47 LEVANSUCRASE
(Erwinia
amylovora) 		4 / 8 GLY A 380
ALA A  71
ASP A  46
PHE A 365
 None
None
FRU  A1415 (-2.9A)
None
 0.98A 5mvsB-4d47A:
undetectable		 5mvsB-4d47A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 GLU X 233
VAL X 234
ASP X 176
ALA X 300
GLY X  46
 FRU  X 801 (-2.8A)
None
FRU  X 801 (-3.0A)
None
None
 1.29A 5syeB-3rwkX:
undetectable		 5syeB-3rwkX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 8 PRO A 442
ASP A 472
SER A 458
PHE A 470
 None
None
FRU  A 601 (-2.9A)
None
 1.10A 5t8sB-3vssA:
undetectable		 5t8sB-3vssA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5fkc BETA-FRUCTOFURANOSID
ASE
(Xanthophyllomyce
s
dendrorhous) 		4 / 7 GLN A  97
GLY A 147
GLN A 388
TYR A  85
 FRU  A3001 ( 3.5A)
None
None
None
 1.15A 5vlmC-5fkcA:
undetectable		 5vlmC-5fkcA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 4 TYR A 457
GLY A 342
ASN A 302
ARG A 281
 FRU  A 601 (-4.8A)
None
None
FRU  A 601 (-4.5A)
 1.22A 5w7bA-3vssA:
undetectable
5w7bC-3vssA:
undetectable		 5w7bA-3vssA:
9.57
5w7bC-3vssA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_1
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 4 SER A 416
ASP A 288
HIS A 291
ASP A 412
 None
None
FRU  A 603 (-4.3A)
None
 1.47A 5x7fA-3vssA:
undetectable		 5x7fA-3vssA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.05A 5z84P-3kf3A:
undetectable
5z84W-3kf3A:
undetectable		 5z84P-3kf3A:
19.12
5z84W-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.07A 5z85P-3kf3A:
undetectable
5z85W-3kf3A:
undetectable		 5z85P-3kf3A:
19.12
5z85W-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.01A 5z86C-3kf3A:
undetectable
5z86J-3kf3A:
undetectable		 5z86C-3kf3A:
19.12
5z86J-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 0.99A 5z86P-3kf3A:
undetectable
5z86W-3kf3A:
undetectable		 5z86P-3kf3A:
19.12
5z86W-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.07A 5zcoP-3kf3A:
undetectable
5zcoW-3kf3A:
undetectable		 5zcoP-3kf3A:
19.12
5zcoW-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.01A 5zcpC-3kf3A:
undetectable
5zcpJ-3kf3A:
undetectable		 5zcpC-3kf3A:
19.12
5zcpJ-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3kf3 INVERTASE
(Schwanniomyces
occidentalis) 		4 / 6 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.05A 5zcpP-3kf3A:
undetectable
5zcpW-3kf3A:
undetectable		 5zcpP-3kf3A:
19.12
5zcpW-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		6 / 12 ILE A 520
GLY A 516
ALA A 518
ASN A 169
ALA A 163
ALA A 164
 None
FRU  A 604 ( 4.7A)
None
None
None
None
 1.34A 5zw4A-3vssA:
undetectable		 5zw4A-3vssA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 2inv INSULIN
FRUCTOTRANSFERASE
(Bacillus
sp.
snu-7) 		4 / 6 GLY A 266
GLY A 268
PRO A 269
GLY A 271
 FRU  A   1 ( 4.1A)
None
None
None
 0.68A 6ag0C-2invA:
undetectable		 6ag0C-2invA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3vss BETA-FRUCTOFURANOSID
ASE
(Microbacterium
saccharophilum) 		4 / 8 PRO A 442
ASP A 472
SER A 458
PHE A 470
 None
None
FRU  A 601 (-2.9A)
None
 1.15A 6fbnB-3vssA:
undetectable		 6fbnB-3vssA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
None
 0.90A 6fhwA-5gooA:
22.9		 6fhwA-5gooA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_1
(GLUCOAMYLASE P)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ASP A  54
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
None
 1.06A 6fhwA-5gooA:
22.9		 6fhwA-5gooA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ARG A  53
ASP A  54
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-4.4A)
GOL  A 502 (-2.9A)
None
 0.90A 6fhwB-5gooA:
23.2		 6fhwB-5gooA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_1
(GLUCOAMYLASE P)		 5goo ALKALINE INVERTASE
(Nostoc
sp.
PCC
7120) 		5 / 12 ALA A  36
TYR A  47
ASP A  54
TYR A 370
TRP A 376
 GOL  A 502 ( 4.2A)
FRU  A 501 (-4.3A)
GOL  A 502 (-2.9A)
FRU  A 501 (-4.8A)
None
 1.06A 6fhwB-5gooA:
23.2		 6fhwB-5gooA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 288
TYR A 392
PRO A 408
VAL A 295
GLY A 302
 None
None
None
None
FRU  A 902 ( 2.2A)
 1.43A 6gngA-3s29A:
16.4		 6gngA-3s29A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 3s29 SUCROSE SYNTHASE 1
(Arabidopsis
thaliana) 		5 / 12 GLY A 303
HIS A 438
ARG A 580
GLU A 675
GLY A 678
 UDP  A 901 ( 2.9A)
None
FRU  A 902 ( 3.7A)
UDP  A 901 (-4.1A)
UDP  A 901 ( 3.7A)
 0.61A 6gngA-3s29A:
16.4		 6gngA-3s29A:
22.85