SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FPP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1
(Aspergillus
fumigatus) 		4 / 7 SER B 463
HIS B 495
TYR B 204
LEU B 208
 None
None
FPP  B 601 ( 4.9A)
None
 1.15A 1ibgL-4mbgB:
undetectable		 1ibgL-4mbgB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ARG A  84
ARG A 207
ARG A  46
 FPP  A 302 (-3.0A)
SO4  A 303 (-3.7A)
FPP  A 302 (-2.8A)
 0.88A 1l7fA-4h8eA:
undetectable		 1l7fA-4h8eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ARG A  84
ARG A 207
ARG A  46
 FPP  A 302 (-3.0A)
SO4  A 303 (-3.7A)
FPP  A 302 (-2.8A)
 0.88A 1l7hA-4h8eA:
undetectable		 1l7hA-4h8eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		7 / 11 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.66A 1rqjA-3aq0A:
29.3		 1rqjA-3aq0A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		7 / 11 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.65A 1rqjB-3aq0A:
29.1		 1rqjB-3aq0A:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 11 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.71A 1yhlA-3aq0A:
23.8		 1yhlA-3aq0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 11 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.61A 1yq7A-3aq0A:
25.1		 1yq7A-3aq0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.72A 1yv5A-3aq0A:
25.3		 1yv5A-3aq0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.81A 1zw5A-3aq0A:
25.8		 1zw5A-3aq0A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 197
ALA A 102
LEU A 139
LEU A 165
VAL A 166
 None
FPP  A1002 (-4.1A)
None
FPP  A1002 ( 4.6A)
FPP  A1002 ( 4.1A)
 1.02A 2c12C-3aq0A:
undetectable		 2c12C-3aq0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 5 LEU A 104
PHE A  99
VAL A 114
ALA A 134
 None
FPP  A 302 (-3.8A)
None
None
 1.20A 2cizA-4h8eA:
undetectable		 2cizA-4h8eA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.69A 2e91A-3aq0A:
22.5		 2e91A-3aq0A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.69A 2e91B-3aq0A:
21.3		 2e91B-3aq0A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.70A 2f89F-3aq0A:
26.4		 2f89F-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 11 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.76A 2f8cF-3aq0A:
26.0		 2f8cF-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.75A 2f8zF-3aq0A:
26.4		 2f8zF-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 12 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.61A 2f94F-3aq0A:
25.8		 2f94F-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.73A 2f9kF-3aq0A:
25.8		 2f9kF-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 9 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.57A 2o1oA-3aq0A:
23.7		 2o1oA-3aq0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.81A 2o1oB-3aq0A:
25.6		 2o1oB-3aq0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.85A 2q58A-3aq0A:
24.0		 2q58A-3aq0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.91A 2q58B-3aq0A:
25.3		 2q58B-3aq0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.54A 2qisA-3aq0A:
25.8		 2qisA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 165
ALA A 102
LEU A 139
ALA A 142
 FPP  A1002 ( 4.6A)
FPP  A1002 (-4.1A)
None
None
 0.86A 2vcvB-3aq0A:
undetectable		 2vcvB-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 197
ALA A 102
LEU A 139
ALA A 142
 None
FPP  A1002 (-4.1A)
None
None
 0.86A 2vcvB-3aq0A:
undetectable		 2vcvB-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 165
ALA A 102
LEU A 139
ALA A 142
 FPP  A1002 ( 4.6A)
FPP  A1002 (-4.1A)
None
None
 0.91A 2vcvK-3aq0A:
1.0		 2vcvK-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 197
ALA A 102
LEU A 139
ALA A 142
 None
FPP  A1002 (-4.1A)
None
None
 0.87A 2vcvK-3aq0A:
1.0		 2vcvK-3aq0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.68A 3ez3A-3aq0A:
25.8		 3ez3A-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.72A 3ez3B-3aq0A:
25.5		 3ez3B-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.71A 3ez3C-3aq0A:
25.8		 3ez3C-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.68A 3ez3D-3aq0A:
25.2		 3ez3D-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.64A 3ibaA-3aq0A:
25.2		 3ibaA-3aq0A:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		3 / 3 ASP A  33
ARG A 201
ARG A  46
 MG  A 301 ( 2.6A)
SO4  A 303 (-3.5A)
FPP  A 302 (-2.8A)
 1.05A 3k37A-4h8eA:
undetectable		 3k37A-4h8eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.69A 3ldwA-3aq0A:
25.7		 3ldwA-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.75A 3ldwB-3aq0A:
25.5		 3ldwB-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.71A 3ldwC-3aq0A:
25.7		 3ldwC-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.76A 3ldwD-3aq0A:
25.3		 3ldwD-3aq0A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 11 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.74A 3n45F-3aq0A:
25.8		 3n45F-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.74A 3n46F-3aq0A:
25.7		 3n46F-3aq0A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.95A 3p50A-4h8eA:
undetectable		 3p50A-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.96A 3p50B-4h8eA:
undetectable		 3p50B-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.95A 3p50C-4h8eA:
undetectable		 3p50C-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.96A 3p50D-4h8eA:
undetectable		 3p50D-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE
(Staphylococcus
aureus) 		4 / 7 PRO A  96
ILE A 150
THR A 127
ILE A 128
 FPP  A 302 ( 3.8A)
None
None
None
 0.97A 3p50E-4h8eA:
undetectable		 3p50E-4h8eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.50A 4kfaA-3aq0A:
25.5		 4kfaA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.67A 4kpdA-3aq0A:
26.3		 4kpdA-3aq0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 9 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.70A 4kpjA-3aq0A:
25.4		 4kpjA-3aq0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.71A 4kq5A-3aq0A:
25.4		 4kq5A-3aq0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.69A 4kqsA-3aq0A:
26.2		 4kqsA-3aq0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
ISY  A1003 (-4.7A)
 0.75A 4n9uA-3aq0A:
25.8		 4n9uA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
ISY  A1003 (-4.7A)
 1.31A 4n9uA-3aq0A:
25.8		 4n9uA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 104
ASP A 107
ASP A 111
ARG A 116
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
ISY  A1003 (-4.7A)
 0.61A 4ng6A-3aq0A:
26.0		 4ng6A-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 104
ASP A 107
ASP A 111
ARG A 116
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
ISY  A1003 (-4.7A)
 1.29A 4ng6A-3aq0A:
26.0		 4ng6A-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.68A 4nkeA-3aq0A:
25.5		 4nkeA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.58A 4nkfA-3aq0A:
25.9		 4nkfA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 104
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.75A 4nkfA-3aq0A:
25.9		 4nkfA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.69A 4nuaA-3aq0A:
25.8		 4nuaA-3aq0A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 9 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.75A 4oguA-3aq0A:
25.6		 4oguA-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.81A 4p0vA-3aq0A:
26.4		 4p0vA-3aq0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 11 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.76A 4p0wA-3aq0A:
26.3		 4p0wA-3aq0A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 197
LEU A 165
ALA A 161
LEU A 139
LEU A 158
 None
FPP  A1002 ( 4.6A)
None
None
None
 1.27A 4p65A-3aq0A:
undetectable
4p65B-3aq0A:
undetectable
4p65F-3aq0A:
undetectable
4p65H-3aq0A:
undetectable		 4p65A-3aq0A:
4.03
4p65B-3aq0A:
8.80
4p65F-3aq0A:
8.80
4p65H-3aq0A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.59A 4q23A-3aq0A:
25.3		 4q23A-3aq0A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.67A 4rxdA-3aq0A:
24.5		 4rxdA-3aq0A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.67A 4rxdB-3aq0A:
24.6		 4rxdB-3aq0A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 10 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.66A 4rxdC-3aq0A:
24.7		 4rxdC-3aq0A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 8 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.65A 4umjA-3aq0A:
28.9		 4umjA-3aq0A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		7 / 9 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.61A 4umjB-3aq0A:
29.1		 4umjB-3aq0A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 12 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.67A 5cg5A-3aq0A:
25.2		 5cg5A-3aq0A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		6 / 12 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.65A 5cg6A-3aq0A:
25.7		 5cg6A-3aq0A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		3 / 3 ASP A 234
LEU A 104
ARG A 116
 None
None
FPP  A1002 (-2.9A)
 0.54A 5e8qA-3aq0A:
undetectable		 5e8qA-3aq0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.74A 5eroA-3aq0A:
25.6		 5eroA-3aq0A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		4 / 5 SER B 303
TYR B 314
GLY B 304
TYR A 147
 None
FPP  B 601 (-4.4A)
None
FPP  B 601 (-4.0A)
 1.44A 5yodH-4mbgB:
undetectable		 5yodH-4mbgB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2
CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1
(Aspergillus
fumigatus;
Aspergillus
fumigatus) 		4 / 7 ASN A 182
ASN A 187
GLU B 309
ARG B 359
 None
None
None
FPP  B 601 (-3.9A)
 1.24A 6b8kA-4mbgA:
undetectable		 6b8kA-4mbgA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 ASP A 107
ASP A 111
ARG A 116
LYS A 193
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.79A 6g31A-3aq0A:
25.6		 6g31A-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 5 ASP A 107
ASP A 111
ARG A 116
LYS A 193
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.79A 6g31C-3aq0A:
25.8		 6g31C-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 LEU A 104
ASP A 107
ASP A 111
ARG A 116
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
 0.46A 6g31D-3aq0A:
25.0		 6g31D-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 4 LEU A 104
ASP A 107
ASP A 111
ARG A 116
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
 0.43A 6g31E-3aq0A:
19.1		 6g31E-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 ASP A 107
ASP A 111
ARG A 116
LYS A 193
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.69A 6g31G-3aq0A:
24.8		 6g31G-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aq0 GERANYL DIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 6 LEU A 104
ASP A 107
ASP A 111
ARG A 116
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
 0.69A 6g31J-3aq0A:
25.8		 6g31J-3aq0A:
13.17