SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FPG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		5 / 9 ASP A 356
ASP A 509
ARG A 315
ASP A 496
LYS A 512
 MN  A 602 (-2.5A)
MN  A 601 ( 3.6A)
FPG  A 600 (-3.1A)
MN  A 603 ( 2.9A)
FPG  A 600 (-3.3A)
 1.35A 2e91A-2ongA:
7.6		 2e91A-2ongA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		5 / 9 ASP A 356
ASP A 509
ARG A 315
ASP A 496
LYS A 512
 MN  A 602 (-2.5A)
MN  A 601 ( 3.6A)
FPG  A 600 (-3.1A)
MN  A 603 ( 2.9A)
FPG  A 600 (-3.3A)
 1.34A 2e91B-2ongA:
11.8		 2e91B-2ongA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		4 / 8 HIS A 579
ILE A 348
TYR A 573
ASP A 352
 FPG  A 600 (-3.3A)
FPG  A 600 (-4.5A)
None
FPG  A 600 (-2.8A)
 1.13A 2v57A-2ongA:
2.0		 2v57A-2ongA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		4 / 8 HIS A 579
ILE A 348
TYR A 573
ASP A 352
 FPG  A 600 (-3.3A)
FPG  A 600 (-4.5A)
None
FPG  A 600 (-2.8A)
 1.12A 2v57C-2ongA:
2.0		 2v57C-2ongA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDR_A_210A822_1
(ALPHA-BISABOLENE
SYNTHASE)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		4 / 4 ASP A 352
ASP A 356
ARG A 493
ASP A 496
 FPG  A 600 (-2.8A)
MN  A 602 (-2.5A)
FPG  A 600 (-3.8A)
MN  A 603 ( 2.9A)
 1.11A 3sdrA-2ongA:
37.4		 3sdrA-2ongA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		4 / 4 ASP A 352
ASP A 356
ARG A 493
ASP A 496
 FPG  A 600 (-2.8A)
MN  A 602 (-2.5A)
FPG  A 600 (-3.8A)
MN  A 603 ( 2.9A)
 1.09A 3sdvA-2ongA:
36.8		 3sdvA-2ongA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		5 / 12 SER A 454
TRP A 324
ALA A 569
ASP A 577
GLY A 499
 FPG  A 600 ( 4.4A)
FPG  A 600 ( 3.8A)
None
None
None
 1.01A 4j7xA-2ongA:
undetectable		 4j7xA-2ongA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		4 / 8 TYR A 573
ARG A 493
ASP A 356
GLU A 503
 None
FPG  A 600 (-3.8A)
MN  A 602 (-2.5A)
None
 1.33A 4kr4C-2ongA:
undetectable		 4kr4C-2ongA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		5 / 9 ASP A 356
ASP A 509
ARG A 315
ASP A 496
ASP A 497
 MN  A 602 (-2.5A)
MN  A 601 ( 3.6A)
FPG  A 600 (-3.1A)
MN  A 603 ( 2.9A)
None
 1.30A 5eroB-2ongA:
11.3		 5eroB-2ongA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_1
(METTL3)		 2ong 4S-LIMONENE SYNTHASE
(Mentha
spicata) 		4 / 4 ASP A 353
HIS A 579
ASN A  64
GLN A 582
 None
FPG  A 600 (-3.3A)
None
None
 1.35A 5il1A-2ongA:
undetectable		 5il1A-2ongA:
17.65