SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FON'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT
(Corynebacterium
sp.
U-96) 		4 / 6 TYR A 649
ASP A 675
VAL A 665
GLY A 677
 None
None
None
FON  A1003 (-3.5A)
 1.28A 1ekjC-1vrqA:
undetectable
1ekjD-1vrqA:
undetectable		 1ekjC-1vrqA:
13.17
1ekjD-1vrqA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT
(Corynebacterium
sp.
U-96) 		4 / 6 ASP A 675
VAL A 665
GLY A 677
TYR A 649
 None
None
FON  A1003 (-3.5A)
None
 1.25A 1ekjC-1vrqA:
undetectable
1ekjD-1vrqA:
undetectable		 1ekjC-1vrqA:
13.17
1ekjD-1vrqA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 4 ILE B  16
LEU A 145
VAL A 126
ILE A 130
 FON  A 451 (-4.1A)
None
None
None
 0.92A 1fm6D-1xzqB:
undetectable		 1fm6D-1xzqB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE
(Sus
scrofa) 		4 / 4 ALA A 232
ARG A 193
GLN A 233
GLU A  81
 None
None
FON  A 330 (-3.2A)
None
 1.24A 1lqtB-1qd1A:
0.0		 1lqtB-1qd1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE
(Sus
scrofa) 		4 / 4 ALA A 232
ARG A 193
GLN A 233
GLU A  81
 None
None
FON  A 330 (-3.2A)
None
 1.22A 1lquB-1qd1A:
0.0		 1lquB-1qd1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3geh TRNA MODIFICATION
GTPASE MNME
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  80
THR A 118
LEU A 127
VAL A 139
 FON  A 461 (-4.1A)
None
None
None
 1.16A 1uyuA-3gehA:
undetectable		 1uyuA-3gehA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 5 LEU B  34
GLY B  48
HIS B  47
ILE B  46
 None
None
FON  A 451 (-3.9A)
None
 0.91A 1xf1A-1xzqB:
undetectable		 1xf1A-1xzqB:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 6 LEU B  34
GLY B  48
HIS B  47
ILE B  46
 None
None
FON  A 451 (-3.9A)
None
 0.87A 1xf1B-1xzqB:
undetectable		 1xf1B-1xzqB:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE
(Sus
scrofa) 		4 / 6 HIS A  82
ASN A 186
GLN A 268
THR A  44
 GOL  A 480 ( 4.1A)
FON  A 330 (-4.0A)
FON  A 330 (-3.0A)
FON  A 330 (-3.1A)
 1.21A 2hkkA-1qd1A:
undetectable		 2hkkA-1qd1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT
(Corynebacterium
sp.
U-96) 		4 / 8 MET A 815
ALA A 729
THR A 727
LEU A 631
 None
None
None
FON  A1003 (-3.8A)
 1.03A 2wx2B-1vrqA:
undetectable		 2wx2B-1vrqA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME
(Thermotoga
maritima) 		4 / 5 TYR B  65
ARG B  20
ILE A  16
THR A   9
 None
FON  B 118 (-4.5A)
FON  B 118 (-4.3A)
None
 1.15A 3dgqA-1xzqB:
0.0		 3dgqA-1xzqB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 9 ILE A  90
ILE A  79
PHE A  76
LYS A   8
GLY A   7
 None
FON  A 402 (-4.0A)
None
T3F  A 403 (-3.2A)
None
 1.30A 3sj4X-4xd0A:
undetectable		 3sj4X-4xd0A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		4 / 8 THR A  16
GLY A   7
PHE A  46
SER A  73
 None
None
None
FON  A 402 ( 4.0A)
 1.04A 3tzfB-4xd0A:
undetectable		 3tzfB-4xd0A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		5 / 8 ILE A  90
ILE A  79
PHE A  76
LYS A   8
GLY A   7
 None
FON  A 402 (-4.0A)
None
T3F  A 403 (-3.2A)
None
 1.37A 4hdlA-4xd0A:
undetectable		 4hdlA-4xd0A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE
(Sus
scrofa) 		3 / 3 ASP A  89
LEU A 182
ARG A 179
 None
FON  A 330 ( 4.5A)
FON  A 330 (-3.7A)
 0.60A 5e8qA-1qd1A:
undetectable		 5e8qA-1qd1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		3 / 3 SER A 189
TYR A 188
TYR A 187
 FON  A 402 ( 4.6A)
None
None
 0.88A 5lakA-4xd0A:
undetectable
5lakI-4xd0A:
undetectable		 5lakA-4xd0A:
22.54
5lakI-4xd0A:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE
(Providencia
alcalifaciens) 		3 / 3 SER A 189
TYR A 188
TYR A 187
 FON  A 402 ( 4.6A)
None
None
 0.83A 5lakC-4xd0A:
undetectable
5lakJ-4xd0A:
undetectable		 5lakC-4xd0A:
22.54
5lakJ-4xd0A:
1.73