SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FOM'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SG9_B_KANB305_1 (APH(2'')-ID)	4zqg	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (Moraxella catarrhalis)	4 / 8	SER A 225 HIS A 212 GLU A 234 GLU A 237	FOM A 503 (-2.5A) FOM A 503 ( 4.6A) MG A 502 ( 2.7A) None	1.14A	3sg9B-4zqgA: undetectable	3sg9B-4zqgA: 21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_C_ZPCC1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	3upy	OXIDOREDUCTASE (Brucella abortus)	5 / 12	VAL A 329 ILE A 38 GLU A 168 GLU A 141 HIS A 323	None None FOM A 447 ( 2.4A) None FOM A 447 (-4.1A)	1.28A	4a97B-3upyA: undetectable 4a97C-3upyA: undetectable	4a97B-3upyA: 19.82 4a97C-3upyA: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LG3_B_Z80B401_1 (GAMMA-AMINOBUTYRIC-A CID RECEPTOR SUBUNIT BETA-1)	4zqg	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (Moraxella catarrhalis)	5 / 9	ILE A 17 VAL A 105 ASN A 230 GLU A 234 ILE A 221	NAD A 501 (-3.9A) NAD A 501 (-4.2A) FOM A 503 (-3.3A) MG A 502 ( 2.7A) NAD A 501 ( 3.8A)	1.41A	5lg3B-4zqgA: 0.9	5lg3B-4zqgA: 21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MUG_A_VIVA301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	3au9	1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (Plasmodium falciparum)	5 / 12	LEU A 368 ILE A 227 TRP A 296 ILE A 89 VAL A 178	None None FOM A 701 (-3.8A) NDP A 501 (-4.4A) None	1.05A	5mugA-3au9A: 2.1	5mugA-3au9A: 19.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3SG9_B_KANB305_1","APH(2'')-ID","4zqg","1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE","Moraxella catarrhalis",4,"SER A 225;HIS A 212;GLU A 234;GLU A 237","FOM A 503 (-2.5A);FOM A 503 ( 4.6A); MG A 502 ( 2.7A);None","1.14A","3sg9B-4zqgA:undetectable",null],["4A97_C_ZPCC1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","3upy","OXIDOREDUCTASE","Brucella abortus",5,"VAL A 329;ILE A  38;GLU A 168;GLU A 141;HIS A 323","None;None;FOM A 447 ( 2.4A);None;FOM A 447 (-4.1A)","1.28A","4a97B-3upyA:undetectable;4a97C-3upyA:undetectable","3sg9B-4zqgA:21.04"],["5LG3_B_Z80B401_1","GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT BETA-1","4zqg","1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE","Moraxella catarrhalis",5,"ILE A  17;VAL A 105;ASN A 230;GLU A 234;ILE A 221","NAD A 501 (-3.9A);NAD A 501 (-4.2A);FOM A 503 (-3.3A); MG A 502 ( 2.7A);NAD A 501 ( 3.8A)","1.41A","5lg3B-4zqgA:0.9","4a97B-3upyA:19.82;4a97C-3upyA:19.82"],["5MUG_A_VIVA301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","3au9","1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE","Plasmodium falciparum",5,"LEU A 368;ILE A 227;TRP A 296;ILE A  89;VAL A 178","None;None;FOM A 701 (-3.8A);NDP A 501 (-4.4A);None","1.05A","5mugA-3au9A:2.1","5lg3B-4zqgA:21.71"]]