SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FOH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 7 LEU A 108
PHE A 112
LEU A 209
SER A 334
 FOH  A 402 (-4.2A)
FOH  A 402 ( 3.7A)
FOH  A 402 (-4.4A)
None
 0.95A 1wrlE-1dgpA:
0.0
1wrlF-1dgpA:
0.0		 1wrlE-1dgpA:
15.33
1wrlF-1dgpA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 ASP A 245
LEU A 287
LYS A 284
MET A 290
 FOH  A 401 (-3.5A)
None
None
None
 1.38A 2gj5A-1dgpA:
undetectable		 2gj5A-1dgpA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 8 LEU A 212
LEU A 107
THR A 175
LEU A 208
 None
None
None
FOH  A 402 ( 4.7A)
 0.80A 2xfhA-1dgpA:
0.7		 2xfhA-1dgpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 5 LEU A 108
LEU A 212
MET A 160
THR A 175
 FOH  A 402 (-4.2A)
None
None
None
 1.46A 4do3A-1dgpA:
undetectable		 4do3A-1dgpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		4 / 8 GLU A 201
ASP A 203
SER A 241
TRP A  46
 None
None
FOH  A 401 (-3.3A)
None
 1.20A 4uhxA-1dgpA:
undetectable		 4uhxA-1dgpA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1dgp ARISTOLOCHENE
SYNTHASE
(Penicillium
roqueforti) 		5 / 10 ALA A 104
LEU A 108
PHE A  65
ILE A 152
LEU A 156
 None
FOH  A 402 (-4.2A)
None
None
None
 1.42A 6h1lA-1dgpA:
1.2		 6h1lA-1dgpA:
21.46