SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FNS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 375
ASN A 157
GLY A 374
VAL A 387
 None
None
FNS  A 570 (-3.2A)
None
 0.84A 1dbbH-1qcwA:
undetectable
1dbbL-1qcwA:
undetectable		 1dbbH-1qcwA:
19.18
1dbbL-1qcwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 384
GLN A 352
LYS A 349
VAL A 368
 None
None
FNS  A 570 (-2.7A)
None
 1.17A 1l2iB-1qcwA:
0.0		 1l2iB-1qcwA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjA-1qcwA:
undetectable		 3fhjA-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjB-1qcwA:
undetectable		 3fhjB-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.14A 3fhjC-1qcwA:
undetectable		 3fhjC-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjD-1qcwA:
undetectable		 3fhjD-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.14A 3fhjE-1qcwA:
undetectable		 3fhjE-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 410
HIS A 158
ILE A 385
VAL A 408
VAL A 429
 FNS  A 570 (-3.5A)
None
None
None
None
 1.15A 3fhjF-1qcwA:
undetectable		 3fhjF-1qcwA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 154
ARG A 433
GLU A 129
 None
FNS  A 570 (-4.1A)
None
 1.14A 3qf1A-1qcwA:
0.0		 3qf1A-1qcwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 THR A 153
GLY A 374
ASN A 372
GLY A 287
 None
FNS  A 570 (-3.2A)
None
None
 0.84A 3tajA-1qcwA:
undetectable		 3tajA-1qcwA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 6 THR A 153
GLY A 374
ASN A 372
GLY A 287
 None
FNS  A 570 (-3.2A)
None
None
 0.86A 4fjpA-1qcwA:
undetectable		 4fjpA-1qcwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 410
GLY A 411
ALA A 160
ASN A 372
GLY A 375
 FNS  A 570 (-3.5A)
FNS  A 570 (-4.0A)
None
None
None
 0.98A 5kb5A-1qcwA:
undetectable		 5kb5A-1qcwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 432
VAL A 418
THR A 416
ALA A 450
LEU A 454
 FNS  A 570 (-3.4A)
None
None
None
None
 0.96A 5kocA-1qcwA:
undetectable		 5kocA-1qcwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 412
ARG A 413
PRO A 434
GLY A 432
 None
FNS  A 570 (-3.3A)
None
FNS  A 570 (-3.4A)
 0.95A 5x80A-1qcwA:
0.0
5x80B-1qcwA:
0.2		 5x80A-1qcwA:
17.75
5x80B-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 412
ARG A 413
PRO A 434
GLY A 432
 None
FNS  A 570 (-3.3A)
None
FNS  A 570 (-3.4A)
 1.01A 5x80C-1qcwA:
undetectable
5x80D-1qcwA:
0.5		 5x80C-1qcwA:
17.75
5x80D-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 5 PRO A 434
GLY A 432
VAL A 412
ARG A 413
 None
FNS  A 570 (-3.4A)
None
FNS  A 570 (-3.3A)
 0.99A 5x80C-1qcwA:
0.0
5x80D-1qcwA:
0.0		 5x80C-1qcwA:
17.75
5x80D-1qcwA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 369
LEU A 370
SER A 371
GLY A 428
GLY A 432
 None
None
FNS  A 570 (-3.6A)
None
FNS  A 570 (-3.4A)
 1.14A 6eu9B-1qcwA:
0.0		 6eu9B-1qcwA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1qcw FLAVOCYTOCHROME B2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 227
GLN A 252
THR A 280
VAL A 281
 None
FNS  A 570 (-3.3A)
FNS  A 570 (-2.8A)
None
 1.05A 6fbvC-1qcwA:
undetectable		 6fbvC-1qcwA:
16.58