SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FNR'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.19A 1c9sQ-3b05A:
undetectable
1c9sR-3b05A:
undetectable		 1c9sQ-3b05A:
13.61
1c9sR-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 SER A 273
GLY A 272
LEU A 270
GLY A 219
VAL A 265
 FNR  A 669 ( 4.5A)
None
None
None
None
 1.11A 1fduC-3b05A:
undetectable		 1fduC-3b05A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.49A 1fohA-3b05A:
undetectable		 1fohA-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.47A 1fohB-3b05A:
undetectable		 1fohB-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1fohC-3b05A:
undetectable		 1fohC-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1fohD-3b05A:
1.8		 1fohD-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.17A 1gtfD-3b05A:
undetectable
1gtfE-3b05A:
undetectable		 1gtfD-3b05A:
13.61
1gtfE-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.23A 1gtfR-3b05A:
undetectable
1gtfS-3b05A:
undetectable		 1gtfR-3b05A:
13.61
1gtfS-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1pn0C-3b05A:
1.6		 1pn0C-3b05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1pn0D-3b05A:
1.5		 1pn0D-3b05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.16A 1utdE-3b05A:
undetectable
1utdF-3b05A:
undetectable		 1utdE-3b05A:
13.61
1utdF-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.15A 1utdH-3b05A:
undetectable
1utdI-3b05A:
undetectable		 1utdH-3b05A:
13.61
1utdI-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.20A 1utdU-3b05A:
undetectable
1utdV-3b05A:
undetectable		 1utdU-3b05A:
13.61
1utdV-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 SER A 251
ASN A 117
ALA A  60
ASN A  59
VAL A 198
 FNR  A 404 ( 4.4A)
FNR  A 404 (-3.0A)
FNR  A 404 (-3.7A)
FNR  A 404 ( 4.0A)
None
 1.46A 2gl0D-4n02A:
undetectable
2gl0E-4n02A:
undetectable		 2gl0D-4n02A:
19.78
2gl0E-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A  95
ASP A 100
THR A 116
THR A  88
GLY A  89
 None
None
None
None
FNR  A 404 (-3.5A)
 0.98A 2uvnA-4n02A:
undetectable		 2uvnA-4n02A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		4 / 6 SER A 251
TYR A  57
VAL A  87
ASP A 202
 FNR  A 404 ( 4.4A)
None
None
None
 1.40A 2x45A-4n02A:
undetectable		 2x45A-4n02A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ILE A  80
ILE A  81
VAL A  64
GLY A  93
VAL A  12
 None
None
None
None
FNR  A 669 ( 4.3A)
 1.29A 3em0A-3b05A:
undetectable		 3em0A-3b05A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 10 TYR A 168
VAL A 141
GLY A 119
VAL A 174
ASN A 117
 None
None
None
None
FNR  A 404 (-3.0A)
 1.30A 3km6A-4n02A:
undetectable		 3km6A-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Streptococcus
pneumoniae) 		5 / 9 TYR A 168
VAL A 141
GLY A 119
VAL A 174
ASN A 117
 None
None
None
None
FNR  A 404 (-3.0A)
 1.30A 3kmoA-4n02A:
undetectable		 3kmoA-4n02A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2ymv ACG NITROREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 GLY A 253
ALA A 252
ASP A 251
ASP A 248
THR A 274
 None
None
None
None
FNR  A1330 (-3.2A)
 1.44A 4eyrB-2ymvA:
undetectable		 4eyrB-2ymvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A 279
ILE A 276
ALA A 293
ARG A 277
PHE A 319
 None
None
None
FNR  A 669 (-2.8A)
None
 1.18A 4kicA-3b05A:
undetectable		 4kicA-3b05A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		6 / 12 ILE A  90
GLY A 279
ILE A 276
ALA A 293
ARG A 277
PHE A 319
 None
None
None
None
FNR  A 669 (-2.8A)
None
 1.30A 4kicB-3b05A:
undetectable		 4kicB-3b05A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 8 HIS A 155
ARG A  98
ASN A 125
ILE A 152
 IPE  A 701 ( 3.4A)
IPE  A 701 (-3.9A)
FNR  A 669 (-3.0A)
None
 1.01A 4l7iA-3b05A:
undetectable		 4l7iA-3b05A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ymv ACG NITROREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  25
ASP A  54
GLU A  59
LEU A  44
GLY A  65
 FNR  A1330 (-4.1A)
None
FNR  A1330 (-4.5A)
None
None
 1.50A 4pgfA-2ymvA:
undetectable		 4pgfA-2ymvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A 274
GLY A 219
GLY A 198
ALA A 282
ASP A 216
 FNR  A 669 (-3.6A)
None
None
None
None
 0.93A 5c0oF-3b05A:
undetectable		 5c0oF-3b05A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eevA-3b05A:
undetectable
5eevB-3b05A:
undetectable		 5eevA-3b05A:
13.61
5eevB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eewA-3b05A:
undetectable
5eewB-3b05A:
undetectable		 5eewA-3b05A:
13.61
5eewB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eexA-3b05A:
undetectable
5eexB-3b05A:
undetectable		 5eexA-3b05A:
13.61
5eexB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eeyA-3b05A:
undetectable
5eeyB-3b05A:
undetectable		 5eeyA-3b05A:
13.61
5eeyB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eezA-3b05A:
undetectable
5eezB-3b05A:
undetectable		 5eezA-3b05A:
13.61
5eezB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef0A-3b05A:
undetectable
5ef0B-3b05A:
undetectable		 5ef0A-3b05A:
13.61
5ef0B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef1A-3b05A:
undetectable
5ef1B-3b05A:
undetectable		 5ef1A-3b05A:
13.61
5ef1B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef2A-3b05A:
undetectable
5ef2B-3b05A:
undetectable		 5ef2A-3b05A:
13.61
5ef2B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef3A-3b05A:
undetectable
5ef3B-3b05A:
undetectable		 5ef3A-3b05A:
13.61
5ef3B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2ymv ACG NITROREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PRO A  30
LEU A  44
PRO A 272
LEU A 256
ARG A 246
 None
None
FNR  A1330 (-4.5A)
None
None
 1.39A 5emlA-2ymvA:
undetectable		 5emlA-2ymvA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A  29
ALA A 290
ARG A 277
PRO A  61
LEU A 321
 None
None
FNR  A 669 (-2.8A)
None
None
 1.38A 5syfB-3b05A:
2.7		 5syfB-3b05A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 ALA A 293
GLY A 294
SER A 273
LEU A 336
ARG A 277
 None
None
FNR  A 669 ( 4.5A)
None
FNR  A 669 (-2.8A)
 1.16A 5w7pA-3b05A:
undetectable		 5w7pA-3b05A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2ymv ACG NITROREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A 274
THR A 277
TRP A  31
PRO A  30
 FNR  A1330 (-3.2A)
None
None
None
 1.11A 5x2sI-2ymvA:
undetectable
5x2sJ-2ymvA:
undetectable
5x2sK-2ymvA:
undetectable		 5x2sI-2ymvA:
19.15
5x2sJ-2ymvA:
19.61
5x2sK-2ymvA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2ymv ACG NITROREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  25
ASP A  54
GLU A  59
LEU A  44
GLY A  65
 FNR  A1330 (-4.1A)
None
FNR  A1330 (-4.5A)
None
None
 1.43A 6aphA-2ymvA:
undetectable		 6aphA-2ymvA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2ymv ACG NITROREDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 125
ARG A 317
ARG A 122
 FNR  A1330 (-3.8A)
FNR  A1330 (-3.2A)
None
 0.98A 6bplA-2ymvA:
undetectable
6bplB-2ymvA:
undetectable		 6bplA-2ymvA:
15.52
6bplB-2ymvA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 6 LEU A  29
THR A  27
GLY A 221
ARG A 277
 None
None
None
FNR  A 669 (-2.8A)
 1.36A 6gtqB-3b05A:
undetectable
6gtqD-3b05A:
undetectable		 6gtqB-3b05A:
18.48
6gtqD-3b05A:
9.09