SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FM6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 MET A 267
PRO A 149
ALA A 274
ALA A 126
 FM6  A 501 (-3.8A)
None
None
NDP  A 601 (-3.4A)
 1.00A 1k5qA-3zhyA:
undetectable
1k5qB-3zhyA:
2.5		 1k5qA-3zhyA:
19.19
1k5qB-3zhyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 157
ASN A 218
ILE A 237
PHE A 230
 None
FM6  A 501 (-3.4A)
None
None
 1.16A 2jn3A-3zhyA:
undetectable		 2jn3A-3zhyA:
14.97