SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FLX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.38A 1os2A-4aigA:
10.8		 1os2A-4aigA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.36A 1os2D-4aigA:
10.8		 1os2D-4aigA:
27.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R55_A_097A518_1
(ADAM 33)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 10 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.34A 1r55A-4aigA:
30.7		 1r55A-4aigA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.26A 1uttA-4aigA:
11.2		 1uttA-4aigA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.36A 1utzA-4aigA:
11.1		 1utzA-4aigA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.33A 1utzB-4aigA:
11.2		 1utzB-4aigA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 6 ILE A 107
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 (-3.9A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.60A 1y93A-4aigA:
11.2		 1y93A-4aigA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.31A 2hu6A-4aigA:
11.2		 2hu6A-4aigA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.21A 2jihA-4aigA:
25.6		 2jihA-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.31A 2jihA-4aigA:
25.6		 2jihA-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 THR A 139
HIS A 142
HIS A 146
HIS A 152
LEU A 170
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.90A 2jihA-4aigA:
25.6		 2jihA-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 8 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.53A 2jihB-4aigA:
25.5		 2jihB-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 8 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.11A 2jihB-4aigA:
25.5		 2jihB-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 8 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.34A 2jihB-4aigA:
25.5		 2jihB-4aigA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 6 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.40A 2ow9A-4aigA:
10.7		 2ow9A-4aigA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.38A 2ow9B-4aigA:
10.6		 2ow9B-4aigA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.41A 2ozrC-4aigA:
10.4		 2ozrC-4aigA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.46A 2ozrD-4aigA:
10.5		 2ozrD-4aigA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.38A 2ozrE-4aigA:
10.5		 2ozrE-4aigA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.67A 3hy7A-4aigA:
26.2		 3hy7A-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.21A 3hy7A-4aigA:
26.2		 3hy7A-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.32A 3hy7A-4aigA:
26.2		 3hy7A-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 9 LEU A 170
THR A 139
HIS A 142
HIS A 146
HIS A 152
 FLX  A 400 (-4.0A)
FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.19A 3hy7B-4aigA:
25.9		 3hy7B-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		6 / 9 THR A 139
HIS A 142
GLU A 143
HIS A 146
HIS A 152
LEU A 170
 FLX  A 400 ( 3.8A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
FLX  A 400 (-4.0A)
 0.53A 3hy7B-4aigA:
25.9		 3hy7B-4aigA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.35A 3kecA-4aigA:
10.7		 3kecA-4aigA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		3 / 3 HIS A 142
GLU A 143
HIS A 146
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
 0.17A 3kecB-4aigA:
10.6		 3kecB-4aigA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.32A 3likA-4aigA:
11.2		 3likA-4aigA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.31A 3lilA-4aigA:
11.3		 3lilA-4aigA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 5 ILE A 107
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 (-3.9A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.56A 3ljgA-4aigA:
11.4		 3ljgA-4aigA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 5 ILE A 108
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 (-4.3A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 1.48A 3ljgA-4aigA:
11.4		 3ljgA-4aigA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 5 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.35A 3lkaA-4aigA:
11.2		 3lkaA-4aigA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 6 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.46A 4a7bA-4aigA:
10.4		 4a7bA-4aigA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 LEU A 170
ILE A 165
HIS A 142
VAL A 138
 FLX  A 400 (-4.0A)
None
ZN  A 999 ( 3.2A)
FLX  A 400 ( 4.9A)
 1.25A 4xyzA-4aigA:
undetectable		 4xyzA-4aigA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		4 / 4 HIS A 142
GLU A 143
HIS A 146
HIS A 152
 ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.32A 5n5jA-4aigA:
11.2		 5n5jA-4aigA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4aig ADAMALYSIN II
(Crotalus
adamanteus) 		5 / 5 ILE A 107
HIS A 142
GLU A 143
HIS A 146
HIS A 152
 FLX  A 400 (-3.9A)
ZN  A 999 ( 3.2A)
FLX  A 400 (-2.8A)
ZN  A 999 ( 3.3A)
ZN  A 999 ( 3.5A)
 0.62A 5n5kA-4aigA:
11.3		 5n5kA-4aigA:
27.36