SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FKY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
ALA A 217
LYS A 219
THR A 264
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.99A 1m17A-6cz4A:
28.4		 1m17A-6cz4A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 197
GLY A 198
VAL A 205
ALA A 217
LEU A 248
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.0A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 ( 4.9A)
 0.78A 1muoA-6cz4A:
11.6		 1muoA-6cz4A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		4 / 6 LEU A 197
LYS A 219
ILE A 262
MET A 267
 FKY  A9001 (-4.1A)
None
None
None
 1.02A 1opjB-6cz4A:
21.3		 1opjB-6cz4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		4 / 7 TYR A 308
GLU A 357
THR A 354
SER A 372
 FKY  A9001 (-4.4A)
None
None
None
 1.05A 1tv8B-6cz4A:
undetectable		 1tv8B-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.51A 1uwhA-6cz4A:
27.2		 1uwhA-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.50A 1uwhB-6cz4A:
26.8		 1uwhB-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.64A 1uwjA-6cz4A:
10.7		 1uwjA-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.64A 1uwjB-6cz4A:
10.7		 1uwjB-6cz4A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ALA A 217
MET A 239
THR A 264
GLY A 270
LEU A 273
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 0.98A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 MET A 239
GLY A 270
LEU A 273
ARG A 277
LEU A 319
ASP A 330
 FKY  A9001 (-4.2A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 ( 4.9A)
None
 0.92A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 MET A 239
THR A 264
GLY A 270
LEU A 273
ARG A 277
LEU A 319
 FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 ( 4.9A)
 0.59A 1xkkA-6cz4A:
30.1		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 9 LEU A 197
VAL A 205
LYS A 219
LEU A 250
LEU A 266
MET A 267
LEU A 333
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.4A)
None
None
 0.83A 1xkkA-6cz4A:
30.2		 1xkkA-6cz4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		4 / 6 LEU A 197
LYS A 219
ILE A 262
MET A 267
 FKY  A9001 (-4.1A)
None
None
None
 1.03A 2hyyC-6cz4A:
22.2		 2hyyC-6cz4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 217
ILE A 262
THR A 264
LEU A 319
ASP A 330
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
None
 0.91A 2hyyD-6cz4A:
21.9		 2hyyD-6cz4A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 9 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.85A 2xp2A-6cz4A:
17.6		 2xp2A-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.62A 2y7jA-6cz4A:
24.3		 2y7jA-6cz4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 10 VAL A 205
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.52A 2y7jB-6cz4A:
18.3		 2y7jB-6cz4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 10 VAL A 205
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.54A 2y7jC-6cz4A:
24.3		 2y7jC-6cz4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 10 VAL A 205
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.51A 2y7jD-6cz4A:
18.0		 2y7jD-6cz4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
ALA A 217
LYS A 219
ILE A 262
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 1.16A 2zvaA-6cz4A:
15.9		 2zvaA-6cz4A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 10 ARG A 195
LEU A 197
ALA A 217
LEU A 266
MET A 267
GLY A 270
LEU A 319
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.83A 3aoxA-6cz4A:
29.0		 3aoxA-6cz4A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 217
MET A 239
LEU A 250
THR A 264
LEU A 266
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.89A 3bbtB-6cz4A:
23.3		 3bbtB-6cz4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 217
MET A 239
LEU A 250
THR A 264
LEU A 266
LEU A 319
LEU A 333
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 ( 4.9A)
None
 0.82A 3bbtB-6cz4A:
23.3		 3bbtB-6cz4A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 10 LEU A 197
VAL A 205
ILE A 262
VAL A 328
ASP A 330
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
FKY  A9001 (-4.7A)
None
 0.64A 3cs9A-6cz4A:
21.8		 3cs9A-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 10 LEU A 197
VAL A 205
LYS A 219
ILE A 262
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.7A)
 0.86A 3cs9A-6cz4A:
21.8		 3cs9A-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ALA A 217
THR A 264
GLY A 270
HIS A 310
ASP A 330
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
None
 0.68A 3cs9B-6cz4A:
22.5		 3cs9B-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 197
VAL A 205
LYS A 219
ILE A 262
LEU A 319
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 ( 4.9A)
FKY  A9001 (-4.7A)
 1.08A 3cs9B-6cz4A:
22.5		 3cs9B-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 LEU A 197
VAL A 205
LYS A 219
ILE A 262
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-3.9A)
 0.97A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 LEU A 197
VAL A 205
LYS A 219
ILE A 262
VAL A 328
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-4.7A)
 0.89A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 VAL A 205
LYS A 219
ILE A 262
MET A 267
PHE A 331
 FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-3.9A)
 1.12A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 VAL A 205
LYS A 219
ILE A 262
MET A 267
VAL A 328
 FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-4.7A)
 1.21A 3cs9C-6cz4A:
22.4		 3cs9C-6cz4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
THR A 264
HIS A 310
ASP A 330
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.9A)
None
 0.59A 3gcsA-6cz4A:
20.0		 3gcsA-6cz4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
VAL A 205
ALA A 217
THR A 264
LEU A 319
ASP A 330
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
None
 0.94A 3ms9A-6cz4A:
30.1		 3ms9A-6cz4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
VAL A 205
ALA A 217
THR A 264
LEU A 319
ASP A 330
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
None
 0.95A 3mssA-6cz4A:
22.1		 3mssA-6cz4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
VAL A 205
ALA A 217
THR A 264
LEU A 319
ASP A 330
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
None
 0.95A 3mssC-6cz4A:
22.0		 3mssC-6cz4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 ILE A 262
MET A 267
ARG A 311
LEU A 319
VAL A 328
 None
None
None
FKY  A9001 ( 4.9A)
FKY  A9001 (-4.7A)
 1.31A 3oxzA-6cz4A:
21.7		 3oxzA-6cz4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 LEU A 197
ILE A 262
MET A 267
LEU A 319
VAL A 328
 FKY  A9001 (-4.1A)
None
None
FKY  A9001 ( 4.9A)
FKY  A9001 (-4.7A)
 1.10A 3oxzA-6cz4A:
21.7		 3oxzA-6cz4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 LEU A 197
LYS A 219
ILE A 262
MET A 267
LEU A 319
 FKY  A9001 (-4.1A)
None
None
None
FKY  A9001 ( 4.9A)
 1.13A 3oxzA-6cz4A:
21.7		 3oxzA-6cz4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 197
VAL A 205
ALA A 217
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.66A 3sxrA-6cz4A:
30.1		 3sxrA-6cz4A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_A_DB8A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
ALA A 217
LYS A 219
ILE A 262
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.95A 3ue4A-6cz4A:
23.0		 3ue4A-6cz4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UE4_B_DB8B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 197
VAL A 205
ALA A 217
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.74A 3ue4B-6cz4A:
29.9		 3ue4B-6cz4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LYS A 219
LEU A 266
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.91A 3ug2A-6cz4A:
28.4		 3ug2A-6cz4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 ALA A 217
LEU A 248
LEU A 266
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-4.4A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.56A 3zbfA-6cz4A:
22.1		 3zbfA-6cz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
ALA A 217
LEU A 248
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.78A 3zbfA-6cz4A:
22.1		 3zbfA-6cz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 ALA A 217
THR A 264
LEU A 303
HIS A 310
ARG A 311
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
None
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.96A 3zosA-6cz4A:
27.8		 3zosA-6cz4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 ALA A 217
THR A 264
LEU A 303
HIS A 310
ARG A 311
LEU A 319
ASP A 330
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
None
FKY  A9001 ( 4.9A)
None
 0.83A 3zosB-6cz4A:
27.7		 3zosB-6cz4A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.66A 4anqA-6cz4A:
29.7		 4anqA-6cz4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 9 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.67A 4ansA-6cz4A:
29.6		 4ansA-6cz4A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 ALA A 217
LEU A 248
ILE A 262
THR A 264
HIS A 310
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.9A)
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.92A 4c8bA-6cz4A:
25.4		 4c8bA-6cz4A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 ALA A 217
ILE A 247
LEU A 248
THR A 264
HIS A 310
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.1A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.9A)
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.92A 4c8bB-6cz4A:
25.6		 4c8bB-6cz4A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LYS A 219
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.84A 4hjoA-6cz4A:
31.8		 4hjoA-6cz4A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXO_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LYS A 219
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.85A 4mxoB-6cz4A:
21.6		 4mxoB-6cz4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LYS A 219
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.96A 4mxxB-6cz4A:
19.8		 4mxxB-6cz4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ALA A 217
THR A 264
LEU A 319
GLY A 329
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
 0.60A 4r7iA-6cz4A:
29.3		 4r7iA-6cz4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 217
THR A 264
LEU A 319
GLY A 329
PHE A 331
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
FKY  A9001 (-3.9A)
 0.76A 4r7iA-6cz4A:
29.3		 4r7iA-6cz4A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ALA A 217
LEU A 248
ILE A 262
THR A 264
SER A 271
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.4A)
 1.16A 4rzvA-6cz4A:
10.5		 4rzvA-6cz4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 ALA A 217
THR A 264
GLY A 270
HIS A 310
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.79A 4u0iA-6cz4A:
29.1		 4u0iA-6cz4A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 9 VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
ASP A 330
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
None
 0.71A 4u5jB-6cz4A:
21.6		 4u5jB-6cz4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 11 LEU A 197
ALA A 217
LYS A 219
THR A 264
MET A 267
GLY A 270
ASN A 317
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 0.78A 4wa9A-6cz4A:
26.9		 4wa9A-6cz4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 217
THR A 264
MET A 267
GLY A 270
ASN A 317
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 0.94A 4wa9B-6cz4A:
29.3		 4wa9B-6cz4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 6 ARG A 195
LEU A 197
ALA A 217
MET A 267
LEU A 319
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 1.05A 4wboC-6cz4A:
21.4		 4wboC-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 LEU A 197
ALA A 217
LYS A 219
THR A 264
LEU A 266
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.93A 4wkqA-6cz4A:
22.6		 4wkqA-6cz4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LYS A 219
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.83A 4xeyB-6cz4A:
29.3		 4xeyB-6cz4A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		4 / 6 ALA A 217
LEU A 266
MET A 267
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 ( 4.9A)
 0.36A 4xoyA-6cz4A:
21.6		 4xoyA-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		4 / 6 ALA A 217
LEU A 266
MET A 267
LEU A 319
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
FKY  A9001 ( 4.9A)
 0.31A 4xp3A-6cz4A:
21.6		 4xp3A-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 9 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.89A 5aaaA-6cz4A:
30.0		 5aaaA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 10 LEU A 197
VAL A 205
ALA A 217
LYS A 219
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.94A 5aabA-6cz4A:
29.7		 5aabA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 10 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.89A 5aabA-6cz4A:
29.7		 5aabA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 10 LEU A 197
VAL A 205
ALA A 217
LYS A 219
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.76A 5aacA-6cz4A:
29.7		 5aacA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 10 LEU A 197
VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.74A 5aacA-6cz4A:
29.7		 5aacA-6cz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LEU A 248
THR A 264
GLY A 329
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.72A 5cswB-6cz4A:
17.8		 5cswB-6cz4A:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ARG A 195
LEU A 197
ALA A 217
LEU A 248
THR A 264
GLY A 329
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 1.09A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ARG A 195
LEU A 197
ALA A 217
THR A 264
LEU A 319
GLY A 329
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 1.07A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
ALA A 217
ILE A 262
THR A 264
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.74A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
ALA A 217
LEU A 248
ILE A 262
THR A 264
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.79A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
ALA A 217
LEU A 248
THR A 264
GLY A 270
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.4A)
 0.93A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 LEU A 197
ALA A 217
THR A 264
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.91A 5h2uC-6cz4A:
35.2		 5h2uC-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
ILE A 262
THR A 264
LEU A 266
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.72A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LEU A 248
ILE A 262
THR A 264
LEU A 266
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.4A)
 0.73A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
LEU A 248
THR A 264
LEU A 266
GLY A 270
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.4A)
 0.84A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		8 / 12 LEU A 197
VAL A 205
ALA A 217
THR A 264
LEU A 266
GLY A 270
LEU A 319
GLY A 329
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
FKY  A9001 (-3.4A)
 0.83A 5h2uD-6cz4A:
35.3		 5h2uD-6cz4A:
93.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 ALA A 217
LEU A 248
THR A 264
LEU A 303
HIS A 310
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.9A)
FKY  A9001 (-3.4A)
 0.51A 5hi2A-6cz4A:
27.7		 5hi2A-6cz4A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 248
ILE A 262
THR A 264
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.63A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 GLY A 200
VAL A 205
ALA A 217
LYS A 219
LEU A 336
ILE A 262
 None
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
None
 1.29A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LEU A 248
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
 0.53A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LYS A 219
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
 0.72A 5hieA-6cz4A:
25.6		 5hieA-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 248
ILE A 262
THR A 264
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.62A 5hieB-6cz4A:
25.6		 5hieB-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 GLY A 200
VAL A 205
ALA A 217
LYS A 219
ILE A 262
 None
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
 0.74A 5hieB-6cz4A:
25.6		 5hieB-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LEU A 248
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
 0.54A 5hieB-6cz4A:
25.6		 5hieB-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LYS A 219
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
 0.71A 5hieB-6cz4A:
25.6		 5hieB-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ALA A 217
LEU A 248
ILE A 262
THR A 264
GLY A 329
 FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.4A)
 0.63A 5hieD-6cz4A:
19.4		 5hieD-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 GLY A 200
VAL A 205
ALA A 217
LYS A 219
ILE A 262
 None
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
 0.75A 5hieD-6cz4A:
19.4		 5hieD-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LEU A 248
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
 0.54A 5hieD-6cz4A:
19.4		 5hieD-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 VAL A 205
ALA A 217
LYS A 219
ILE A 262
THR A 264
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
None
FKY  A9001 (-3.0A)
 0.71A 5hieD-6cz4A:
19.4		 5hieD-6cz4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 10 GLY A 198
VAL A 205
ALA A 217
LEU A 266
MET A 267
 FKY  A9001 ( 4.0A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
 0.34A 5lw1E-6cz4A:
19.6		 5lw1E-6cz4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 9 GLY A 198
VAL A 205
ALA A 217
LEU A 266
MET A 267
 FKY  A9001 ( 4.0A)
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.4A)
None
 0.37A 5lw1H-6cz4A:
19.9		 5lw1H-6cz4A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 10 LEU A 197
VAL A 205
ILE A 262
MET A 267
GLY A 270
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
 1.04A 5mo4A-6cz4A:
21.1		 5mo4A-6cz4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 10 LEU A 197
VAL A 205
LYS A 219
ILE A 262
MET A 267
PHE A 331
 FKY  A9001 (-4.1A)
FKY  A9001 ( 4.6A)
None
None
None
FKY  A9001 (-3.9A)
 0.99A 5mo4A-6cz4A:
21.1		 5mo4A-6cz4A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
 FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
 0.94A 5nnaA-6cz4A:
undetectable		 5nnaA-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
 FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
 0.94A 5nnaB-6cz4A:
undetectable		 5nnaB-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
 FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
 0.94A 5nnaC-6cz4A:
undetectable		 5nnaC-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		5 / 12 ILE A 247
LEU A 242
GLY A 329
ASP A 330
HIS A 310
 FKY  A9001 (-4.1A)
FKY  A9001 (-4.7A)
FKY  A9001 (-3.4A)
None
FKY  A9001 (-3.9A)
 0.94A 5nnaD-6cz4A:
undetectable		 5nnaD-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 217
ILE A 262
THR A 264
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.41A 5p9iA-6cz4A:
33.4		 5p9iA-6cz4A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_1
(TYROSINE-PROTEIN
KINASE BTK)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 217
MET A 239
ILE A 262
THR A 264
GLY A 270
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-4.2A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
 0.57A 5p9iA-6cz4A:
33.4		 5p9iA-6cz4A:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		6 / 12 VAL A 205
ALA A 217
LYS A 219
MET A 239
GLY A 270
LEU A 333
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-4.2A)
FKY  A9001 (-3.3A)
None
 1.27A 5yu9D-6cz4A:
22.2		 5yu9D-6cz4A:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)		 6cz4 PROTEIN-TYROSINE
KINASE 6
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 217
ILE A 262
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.64A 6fnmA-6cz4A:
24.4		 6fnmA-6cz4A:
12.79