SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FIX'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOD_A_HQEA1173_1 (FMN-BINDING PROTEIN)	3hka	URONATE ISOMERASE (Bacillus halodurans)	4 / 7	TYR A 48 ARG A 170 HIS A 26 HIS A 49	None FIX A 428 (-2.9A) ZN A 430 ( 3.3A) FIX A 428 ( 4.1A)	1.48A	3zodA-3hkaA: undetectable	3zodA-3hkaA: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ZOD_A_HQEA1173_1 (FMN-BINDING PROTEIN)	3hka	URONATE ISOMERASE (Bacillus halodurans)	4 / 7	TYR A 50 ARG A 170 HIS A 26 HIS A 49	FIX A 428 ( 4.5A) FIX A 428 (-2.9A) ZN A 430 ( 3.3A) FIX A 428 ( 4.1A)	1.27A	3zodA-3hkaA: undetectable	3zodA-3hkaA: 19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_B_SAMB301_1 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	3hka	URONATE ISOMERASE (Bacillus halodurans)	3 / 3	ASP A 271 GLU A 44 SER A 223	None None FIX A 428 ( 4.1A)	0.79A	5bw4B-3hkaA: undetectable	5bw4B-3hkaA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U63_A_ACTA406_0 (THIOREDOXIN REDUCTASE)	3hka	URONATE ISOMERASE (Bacillus halodurans)	3 / 3	HIS A 26 SER A 354 ARG A 357	ZN A 430 ( 3.3A) None FIX A 428 (-3.9A)	0.96A	5u63A-3hkaA: undetectable	5u63A-3hkaA: 20.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3ZOD_A_HQEA1173_1","FMN-BINDING PROTEIN","3hka","URONATE ISOMERASE","Bacillus halodurans",4,"TYR A  48;ARG A 170;HIS A  26;HIS A  49","None;FIX A 428 (-2.9A); ZN A 430 ( 3.3A);FIX A 428 ( 4.1A)","1.48A","3zodA-3hkaA:undetectable",null],["3ZOD_A_HQEA1173_1","FMN-BINDING PROTEIN","3hka","URONATE ISOMERASE","Bacillus halodurans",4,"TYR A  50;ARG A 170;HIS A  26;HIS A  49","FIX A 428 ( 4.5A);FIX A 428 (-2.9A); ZN A 430 ( 3.3A);FIX A 428 ( 4.1A)","1.27A","3zodA-3hkaA:undetectable","3zodA-3hkaA:19.63"],["5BW4_B_SAMB301_1","16S RRNA (ADENINE(1408)-N(1))-METHYLTRANSFERASE","3hka","URONATE ISOMERASE","Bacillus halodurans",3,"ASP A 271;GLU A  44;SER A 223","None;None;FIX A 428 ( 4.1A)","0.79A","5bw4B-3hkaA:undetectable","3zodA-3hkaA:19.63"],["5U63_A_ACTA406_0","THIOREDOXIN REDUCTASE","3hka","URONATE ISOMERASE","Bacillus halodurans",3,"HIS A  26;SER A 354;ARG A 357"," ZN A 430 ( 3.3A);None;FIX A 428 (-3.9A)","0.96A","5u63A-3hkaA:undetectable","5bw4B-3hkaA:21.60"]]