SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FIJ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JTV_A_TESA500_1 (17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1)	5f8p	ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO (Homo sapiens)	4 / 8	LEU A 109 PRO A 93 HIS A 231 VAL A 228	FIJ A 602 (-4.7A) FIJ A 602 (-4.5A) FIJ A 602 (-4.0A) AKG A 603 ( 4.7A)	1.12A	1jtvA-5f8pA: undetectable	1jtvA-5f8pA: 22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4QKN_A_JMSA602_1 (ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO)	5f8p	ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO (Homo sapiens)	6 / 8	LEU A 90 THR A 92 PRO A 93 ARG A 96 LEU A 109 HIS A 231	FIJ A 602 (-3.9A) FIJ A 602 (-3.7A) FIJ A 602 (-4.5A) AKG A 603 (-3.4A) FIJ A 602 (-4.7A) FIJ A 602 (-4.0A)	0.72A	4qknA-5f8pA: 56.8	4qknA-5f8pA: 99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4QKN_A_JMSA602_1 (ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO)	5f8p	ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO (Homo sapiens)	7 / 8	LEU A 90 THR A 92 PRO A 93 LEU A 109 VAL A 228 SER A 229 HIS A 231	FIJ A 602 (-3.9A) FIJ A 602 (-3.7A) FIJ A 602 (-4.5A) FIJ A 602 (-4.7A) AKG A 603 ( 4.7A) FIJ A 602 (-2.9A) FIJ A 602 (-4.0A)	0.71A	4qknA-5f8pA: 56.8	4qknA-5f8pA: 99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CP4_A_CAMA422_0 (CYTOCHROME P450CAM)	5f8p	ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO (Homo sapiens)	5 / 9	TYR A 106 THR A 111 LEU A 203 THR A 92 VAL A 83	None None None FIJ A 602 (-3.7A) None	1.40A	5cp4A-5f8pA: undetectable	5cp4A-5f8pA: 21.12

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JTV_A_TESA500_1","17 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1","5f8p","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","Homo sapiens",4,"LEU A 109;PRO A  93;HIS A 231;VAL A 228","FIJ A 602 (-4.7A);FIJ A 602 (-4.5A);FIJ A 602 (-4.0A);AKG A 603 ( 4.7A)","1.12A","1jtvA-5f8pA:undetectable",null],["4QKN_A_JMSA602_1","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","5f8p","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","Homo sapiens",6,"LEU A  90;THR A  92;PRO A  93;ARG A  96;LEU A 109;HIS A 231","FIJ A 602 (-3.9A);FIJ A 602 (-3.7A);FIJ A 602 (-4.5A);AKG A 603 (-3.4A);FIJ A 602 (-4.7A);FIJ A 602 (-4.0A)","0.72A","4qknA-5f8pA:56.8","1jtvA-5f8pA:22.55"],["4QKN_A_JMSA602_1","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","5f8p","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","Homo sapiens",7,"LEU A  90;THR A  92;PRO A  93;LEU A 109;VAL A 228;SER A 229;HIS A 231","FIJ A 602 (-3.9A);FIJ A 602 (-3.7A);FIJ A 602 (-4.5A);FIJ A 602 (-4.7A);AKG A 603 ( 4.7A);FIJ A 602 (-2.9A);FIJ A 602 (-4.0A)","0.71A","4qknA-5f8pA:56.8","4qknA-5f8pA:99.58"],["5CP4_A_CAMA422_0","CYTOCHROME P450CAM","5f8p","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","Homo sapiens",5,"TYR A 106;THR A 111;LEU A 203;THR A  92;VAL A  83","None;None;None;FIJ A 602 (-3.7A);None","1.40A","5cp4A-5f8pA:undetectable","4qknA-5f8pA:99.58"]]