SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FGP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 GLY A 275
ASP A  32
SER A 272
 None
FGP  A  70 (-3.0A)
None
 0.70A 2qhfA-4mivA:
undetectable		 2qhfA-4mivA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 7 GLN A  93
HIS A  96
HIS A 368
HIS A 125
 None
None
FGP  A  70 ( 4.4A)
FGP  A  70 ( 3.7A)
 1.20A 3ai8A-4mivA:
undetectable		 3ai8A-4mivA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 6 HIS A 368
HIS A 125
SER A  71
ASP A 477
 FGP  A  70 ( 4.4A)
FGP  A  70 ( 3.7A)
FGP  A  70 ( 4.1A)
None
 1.38A 4blvA-4mivA:
2.2		 4blvA-4mivA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 281
ASP A  32
GLU A 447
ASN A 274
LEU A 285
 None
FGP  A  70 (-3.0A)
None
CA  A 601 (-3.0A)
None
 1.10A 4fr0A-4mivA:
undetectable		 4fr0A-4mivA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		3 / 3 SER A  69
GLU A 140
GLU A 129
 FGP  A  70 ( 3.3A)
None
None
 0.61A 4ymgB-4mivA:
undetectable		 4ymgB-4mivA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 ASP A  32
ARG A 182
HIS A 181
ASP A 235
 FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
 1.12A 6mn4A-4mivA:
undetectable		 6mn4A-4mivA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens) 		4 / 8 ASP A  32
ARG A 182
HIS A 181
ASP A 235
 FGP  A  70 (-3.0A)
None
FGP  A  70 ( 4.5A)
None
 1.23A 6mn4D-4mivA:
undetectable		 6mn4D-4mivA:
20.43