SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FFO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ6_A_FOLA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		5 / 9 TYR A  83
TYR A 168
TYR A 188
GLU A 195
TYR A 236
 FFO  A2887 (-3.9A)
None
FFO  A2887 (-3.5A)
FFO  A2887 (-2.8A)
FFO  A2887 (-3.9A)
 0.73A 1pj6A-1wopA:
48.0		 1pj6A-1wopA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		5 / 12 TYR A  83
ASN A 112
TYR A 168
TYR A 188
TYR A 236
 FFO  A2887 (-3.9A)
FFO  A2887 (-3.3A)
None
FFO  A2887 (-3.5A)
FFO  A2887 (-3.9A)
 0.64A 1pj7A-1wopA:
48.4		 1pj7A-1wopA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		12 / 12 MET A  51
TYR A  83
VAL A  98
TYR A 100
VAL A 110
ASN A 112
TYR A 168
TYR A 169
TYR A 188
ARG A 227
TYR A 236
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-3.9A)
FFO  A2887 (-4.0A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
None
FFO  A2887 (-3.6A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
FFO  A2887 (-3.9A)
None
 0.00A 1wopA-1wopA:
65.4		 1wopA-1wopA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		3 / 3 ASP A  96
GLU A 195
ARG A 362
 FFO  A2887 (-3.1A)
FFO  A2887 (-2.8A)
FFO  A2887 (-3.4A)
 0.00A 1wopA-1wopA:
65.4		 1wopA-1wopA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		10 / 10 LEU A  55
GLU A 106
LEU A 108
ILE A 137
GLU A 160
LYS A 173
ILE A 175
GLU A 180
LEU A 182
MET A 197
 FFO  A2888 (-3.4A)
FFO  A2888 (-2.9A)
FFO  A2888 (-4.2A)
None
FFO  A2888 (-2.8A)
FFO  A2888 (-2.6A)
FFO  A2888 (-4.7A)
FFO  A2888 (-3.7A)
FFO  A2888 (-4.2A)
FFO  A2888 (-3.5A)
 0.00A 1wopA-1wopA:
65.4		 1wopA-1wopA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		6 / 12 MET A  51
VAL A 110
ASN A 112
TYR A 188
ARG A 227
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
None
 0.53A 1wsvA-1wopA:
50.1		 1wsvA-1wopA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		3 / 3 ASP A  96
GLU A 195
TYR A 168
 FFO  A2887 (-3.1A)
FFO  A2887 (-2.8A)
None
 0.83A 1wsvA-1wopA:
50.1		 1wsvA-1wopA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		5 / 12 MET A  51
VAL A 110
ASN A 112
TYR A 188
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
None
 0.55A 1wsvB-1wopA:
50.2		 1wsvB-1wopA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WSV_B_THHB4001_1
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		4 / 4 ASP A  96
GLU A 195
ARG A 227
TYR A 168
 FFO  A2887 (-3.1A)
FFO  A2887 (-2.8A)
FFO  A2887 (-3.6A)
None
 1.06A 1wsvB-1wopA:
50.2		 1wsvB-1wopA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		4 / 4 LEU A 108
LEU A  97
MET A 197
MET A  51
 FFO  A2888 (-4.2A)
None
FFO  A2888 (-3.5A)
FFO  A2887 (-4.6A)
 1.05A 2oaxB-1wopA:
0.0		 2oaxB-1wopA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		8 / 12 MET A  51
TYR A  83
ASP A  96
TYR A 100
VAL A 110
ASN A 112
TYR A 188
ARG A 227
 FFO  A2887 (-4.6A)
FFO  A2887 (-3.9A)
FFO  A2887 (-3.1A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
 0.53A 3a8iA-1wopA:
48.1		 3a8iA-1wopA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		9 / 12 MET A  51
TYR A  83
ASP A  96
TYR A 100
VAL A 110
ASN A 112
TYR A 188
ARG A 227
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-3.9A)
FFO  A2887 (-3.1A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
None
 0.50A 3a8iB-1wopA:
47.6		 3a8iB-1wopA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		5 / 12 TYR A  83
ASP A  96
VAL A 111
TYR A 188
TRP A 256
 FFO  A2887 (-3.9A)
FFO  A2887 (-3.1A)
None
FFO  A2887 (-3.5A)
None
 1.40A 3a8iB-1wopA:
47.6		 3a8iB-1wopA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		8 / 12 MET A  51
TYR A  83
TYR A 100
VAL A 110
ASN A 112
TYR A 188
ARG A 227
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-3.9A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
None
 0.55A 3a8iC-1wopA:
47.9		 3a8iC-1wopA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		8 / 12 TYR A  83
TYR A 100
VAL A 110
ASN A 112
THR A 186
TYR A 188
ARG A 227
TRP A 256
 FFO  A2887 (-3.9A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 ( 4.9A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
None
 0.43A 3a8iC-1wopA:
47.9		 3a8iC-1wopA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		9 / 12 MET A  51
TYR A  83
ASP A  96
TYR A 100
VAL A 110
ASN A 112
TYR A 188
ARG A 227
TRP A 256
 FFO  A2887 (-4.6A)
FFO  A2887 (-3.9A)
FFO  A2887 (-3.1A)
None
FFO  A2887 (-4.0A)
FFO  A2887 (-3.3A)
FFO  A2887 (-3.5A)
FFO  A2887 (-3.6A)
None
 0.57A 3a8iD-1wopA:
47.9		 3a8iD-1wopA:
40.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		5 / 12 TYR A  83
ASP A  96
VAL A 111
TYR A 188
TRP A 256
 FFO  A2887 (-3.9A)
FFO  A2887 (-3.1A)
None
FFO  A2887 (-3.5A)
None
 1.47A 3a8iD-1wopA:
47.9		 3a8iD-1wopA:
40.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		5 / 9 PRO A 221
GLY A  44
ALA A 222
ASP A  47
ARG A 227
 None
None
None
None
FFO  A2887 (-3.6A)
 1.35A 3ur0C-1wopA:
0.0		 3ur0C-1wopA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		4 / 8 TRP A 256
THR A 235
TYR A  83
TYR A 236
 None
None
FFO  A2887 (-3.9A)
FFO  A2887 (-3.9A)
 1.35A 3wipA-1wopA:
0.0
3wipE-1wopA:
0.0		 3wipA-1wopA:
21.73
3wipE-1wopA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		4 / 5 VAL A  48
ARG A 227
GLY A 187
TYR A 188
 None
FFO  A2887 (-3.6A)
None
FFO  A2887 (-3.5A)
 1.13A 5x80A-1wopA:
undetectable
5x80B-1wopA:
undetectable		 5x80A-1wopA:
17.96
5x80B-1wopA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		4 / 5 GLY A 187
TYR A 188
VAL A  48
ARG A 227
 None
FFO  A2887 (-3.5A)
None
FFO  A2887 (-3.6A)
 1.22A 5x80C-1wopA:
undetectable
5x80D-1wopA:
undetectable		 5x80C-1wopA:
17.96
5x80D-1wopA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1wop AMINOMETHYLTRANSFERA
SE
(Thermotoga
maritima) 		3 / 3 VAL A  98
TYR A  83
GLU A 195
 FFO  A2887 (-4.0A)
FFO  A2887 (-3.9A)
FFO  A2887 (-2.8A)
 0.97A 5zmqD-1wopA:
undetectable
5zmqE-1wopA:
undetectable		 5zmqD-1wopA:
19.01
5zmqE-1wopA:
10.19