SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FEO'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 5 HIS A 226
LEU A  12
LEU A  91
GLY A  14
 FEO  A 404 ( 3.2A)
None
None
None
 1.15A 1a4lB-1e5dA:
undetectable		 1a4lB-1e5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 12 HIS A 228
HIS A  90
GLU A  87
HIS A  85
ASP A 168
 FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-2.9A)
FEO  A 401 (-3.4A)
FEO  A 401 (-2.5A)
 1.34A 1a4lD-1vmeA:
undetectable		 1a4lD-1vmeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 12 HIS A  85
ASP A 155
GLY A  88
HIS A 230
ASP A 171
 FEO  A 701 (-3.5A)
None
None
FEO  A 701 ( 3.3A)
FEO  A 701 ( 2.5A)
 1.32A 1a4lD-2q9uA:
undetectable		 1a4lD-2q9uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 12 HIS A 230
HIS A  90
GLU A  87
HIS A  85
ASP A 171
 FEO  A 701 ( 3.3A)
FEO  A 701 (-3.3A)
FEO  A 701 (-2.9A)
FEO  A 701 (-3.5A)
FEO  A 701 ( 2.5A)
 1.35A 1a4lD-2q9uA:
undetectable		 1a4lD-2q9uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 12 HIS A 227
HIS A  84
GLU A  81
HIS A  79
ASP A 166
 FEO  A 501 ( 3.3A)
FEO  A 501 (-3.2A)
FEO  A 501 (-3.1A)
FEO  A 501 (-3.3A)
FEO  A 501 ( 2.5A)
 1.35A 1a4lD-5lmcA:
undetectable		 1a4lD-5lmcA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 8 ASP A 168
HIS A  85
HIS A  90
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.4A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.78A 1ei6D-1vmeA:
1.6		 1ei6D-1vmeA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 8 ASP A 171
HIS A  85
HIS A  90
HIS A 152
 FEO  A 701 ( 2.5A)
FEO  A 701 (-3.5A)
FEO  A 701 (-3.3A)
FEO  A 701 ( 3.4A)
 0.86A 1ei6D-2q9uA:
undetectable		 1ei6D-2q9uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 8 ASP A 166
HIS A  79
HIS A  84
HIS A 147
 FEO  A 501 ( 2.5A)
FEO  A 501 (-3.3A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.4A)
 0.87A 1ei6D-5lmcA:
undetectable		 1ei6D-5lmcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
HIS A  59
TYR A 126
PHE A  67
 FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
None
None
 1.25A 1eqbA-2awcA:
undetectable
1eqbB-2awcA:
undetectable		 1eqbA-2awcA:
15.44
1eqbB-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 TYR A 126
PHE A  67
HIS A 118
HIS A  59
 None
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 1.25A 1eqbA-2awcA:
undetectable
1eqbB-2awcA:
undetectable		 1eqbA-2awcA:
15.44
1eqbB-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
HIS A  59
TYR A 126
PHE A  67
 FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
None
None
 1.24A 1eqbC-2awcA:
undetectable
1eqbD-2awcA:
undetectable		 1eqbC-2awcA:
15.44
1eqbD-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 TYR A 126
PHE A  67
HIS A 118
HIS A  59
 None
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 1.24A 1eqbC-2awcA:
undetectable
1eqbD-2awcA:
undetectable		 1eqbC-2awcA:
15.44
1eqbD-2awcA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 12 TYR A 101
LEU A 138
LEU A 130
HIS A  84
ILE A  40
 None
None
None
FEO  A 501 (-3.2A)
None
 1.19A 1fmlA-5lmcA:
undetectable		 1fmlA-5lmcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 12 TYR A 101
LEU A 138
LEU A 130
HIS A  84
ILE A  40
 None
None
None
FEO  A 501 (-3.2A)
None
 1.19A 1fmlB-5lmcA:
2.6		 1fmlB-5lmcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 GLU A  81
HIS A  24
HIS A 146
ASP A 165
PRO A 224
 FEO  A 404 (-2.6A)
OXY  A 405 ( 4.8A)
FEO  A 404 (-3.3A)
FEO  A 404 ( 2.3A)
None
 1.35A 1ituA-1e5dA:
undetectable		 1ituA-1e5dA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 12 GLU A  83
HIS A  25
HIS A 148
TYR A 195
ASP A 167
 EDO  A 602 (-2.2A)
EDO  A 602 ( 2.9A)
FEO  A 501 (-2.8A)
None
FEO  A 501 ( 2.4A)
 1.37A 1ituA-1ycgA:
undetectable		 1ituA-1ycgA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 GLU A  81
HIS A  24
HIS A 146
ASP A 165
PRO A 224
 FEO  A 404 (-2.6A)
OXY  A 405 ( 4.8A)
FEO  A 404 (-3.3A)
FEO  A 404 ( 2.3A)
None
 1.37A 1ituB-1e5dA:
undetectable		 1ituB-1e5dA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 12 GLU A  83
HIS A  25
HIS A 148
TYR A 195
ASP A 167
 EDO  A 602 (-2.2A)
EDO  A 602 ( 2.9A)
FEO  A 501 (-2.8A)
None
FEO  A 501 ( 2.4A)
 1.38A 1ituB-1ycgA:
undetectable		 1ituB-1ycgA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.29A 1v7zA-1hmdA:
undetectable		 1v7zA-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.26A 1v7zA-2awcA:
undetectable		 1v7zA-2awcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zA-2mhrA:
undetectable		 1v7zA-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.15A 1v7zA-2mhrA:
undetectable		 1v7zA-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.31A 1v7zB-1hmdA:
undetectable		 1v7zB-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.27A 1v7zB-2awcA:
undetectable		 1v7zB-2awcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.33A 1v7zB-2mhrA:
undetectable		 1v7zB-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.16A 1v7zB-2mhrA:
undetectable		 1v7zB-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.34A 1v7zC-1hmdA:
undetectable		 1v7zC-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.31A 1v7zC-2awcA:
undetectable		 1v7zC-2awcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.35A 1v7zC-2mhrA:
undetectable		 1v7zC-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.19A 1v7zC-2mhrA:
undetectable		 1v7zC-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.29A 1v7zD-1hmdA:
undetectable		 1v7zD-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zD-2mhrA:
undetectable		 1v7zD-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.14A 1v7zD-2mhrA:
undetectable		 1v7zD-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.29A 1v7zE-1hmdA:
undetectable		 1v7zE-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.31A 1v7zE-2mhrA:
undetectable		 1v7zE-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.14A 1v7zE-2mhrA:
undetectable		 1v7zE-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.33A 1v7zF-1hmdA:
undetectable		 1v7zF-1hmdA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.35A 1v7zF-2mhrA:
undetectable		 1v7zF-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.18A 1v7zF-2mhrA:
undetectable		 1v7zF-2mhrA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 6 ILE A  21
HIS A  73
HIS A  77
HIS A 101
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.95A 1y93A-1hmdA:
undetectable		 1y93A-1hmdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 6 ILE A  21
HIS A  77
HIS A 101
HIS A  73
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.73A 1y93A-1hmdA:
undetectable		 1y93A-1hmdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 6 ILE A  21
HIS A 101
HIS A  73
HIS A  77
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.90A 1y93A-1hmdA:
undetectable		 1y93A-1hmdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 6 ILE A  19
HIS A  78
HIS A  82
HIS A 118
 None
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 0.87A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 6 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.82A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 6 ILE A  19
HIS A 118
HIS A  78
HIS A  82
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
 0.82A 1y93A-2awcA:
undetectable		 1y93A-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		4 / 8 TYR A 195
ASN A 166
HIS A  81
GLU A  83
 None
None
FEO  A 501 (-3.3A)
EDO  A 602 (-2.2A)
 0.99A 2bnnA-1ycgA:
undetectable
2bnnB-1ycgA:
undetectable		 2bnnA-1ycgA:
18.14
2bnnB-1ycgA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 LEU A 118
HIS A  77
HIS A  73
HIS A 106
THR A  56
 None
FEO  A 119 (-3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
None
 1.37A 2dttD-2mhrA:
undetectable
2dttE-2mhrA:
undetectable		 2dttD-2mhrA:
17.89
2dttE-2mhrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 12 HIS A  85
ASP A 155
GLY A  88
HIS A 230
ASP A 171
 FEO  A 701 (-3.5A)
None
None
FEO  A 701 ( 3.3A)
FEO  A 701 ( 2.5A)
 1.43A 2pgfA-2q9uA:
undetectable		 2pgfA-2q9uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		5 / 11 ASP A  89
HIS A  90
HIS A 151
ASP A 168
HIS A 228
 FEO  A 401 (-2.4A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
 0.99A 2q0jB-1vmeA:
20.2		 2q0jB-1vmeA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 11 ASP A  85
HIS A  86
HIS A 148
ASP A 167
HIS A 228
 FEO  A 501 ( 2.4A)
FEO  A 501 (-3.1A)
FEO  A 501 (-2.8A)
FEO  A 501 ( 2.4A)
FEO  A 501 ( 3.1A)
 0.76A 2q0jB-1ycgA:
18.7		 2q0jB-1ycgA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 11 ASP A  89
HIS A  90
HIS A 152
ASP A 171
HIS A 230
 FEO  A 701 ( 2.4A)
FEO  A 701 (-3.3A)
FEO  A 701 ( 3.4A)
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.3A)
 0.88A 2q0jB-2q9uA:
20.3		 2q0jB-2q9uA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 11 ASP A  83
HIS A  84
HIS A 147
ASP A 166
HIS A 227
 FEO  A 501 ( 2.5A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.4A)
FEO  A 501 ( 2.5A)
FEO  A 501 ( 3.3A)
 0.78A 2q0jB-5lmcA:
19.6		 2q0jB-5lmcA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3chi P-AMINOBENZOATE
N-OXYGENASE
(Streptomyces
thioluteus) 		3 / 3 GLU A 101
HIS A 230
GLU A 196
 FEO  A 501 (-2.1A)
FEO  A 501 (-3.2A)
FEO  A 501 (-2.1A)
 0.70A 2x45B-3chiA:
undetectable		 2x45B-3chiA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3chi P-AMINOBENZOATE
N-OXYGENASE
(Streptomyces
thioluteus) 		3 / 3 GLU A 196
HIS A 139
GLU A 101
 FEO  A 501 (-2.1A)
FEO  A 501 (-3.3A)
FEO  A 501 (-2.1A)
 0.64A 2x45B-3chiA:
undetectable		 2x45B-3chiA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3chi P-AMINOBENZOATE
N-OXYGENASE
(Streptomyces
thioluteus) 		3 / 3 GLU A 101
HIS A 230
GLU A 196
 FEO  A 501 (-2.1A)
FEO  A 501 (-3.2A)
FEO  A 501 (-2.1A)
 0.70A 2x45C-3chiA:
undetectable		 2x45C-3chiA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3chi P-AMINOBENZOATE
N-OXYGENASE
(Streptomyces
thioluteus) 		3 / 3 GLU A 196
HIS A 139
GLU A 101
 FEO  A 501 (-2.1A)
FEO  A 501 (-3.3A)
FEO  A 501 (-2.1A)
 0.64A 2x45C-3chiA:
undetectable		 2x45C-3chiA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 8 HIS A 101
ASP A 106
ILE A  21
HIS A  77
 FEO  A 115 (-3.4A)
FEO  A 115 (-2.6A)
None
FEO  A 115 (-3.4A)
 0.88A 2xadA-1hmdA:
undetectable		 2xadA-1hmdA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 8 HIS A 101
ASP A 106
ILE A  21
HIS A  77
 FEO  A 115 (-3.4A)
FEO  A 115 (-2.6A)
None
FEO  A 115 (-3.4A)
 0.93A 2xadB-1hmdA:
undetectable		 2xadB-1hmdA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 8 HIS A 101
ASP A 106
ILE A  21
HIS A  77
 FEO  A 115 (-3.4A)
FEO  A 115 (-2.6A)
None
FEO  A 115 (-3.4A)
 0.86A 2xadC-1hmdA:
undetectable		 2xadC-1hmdA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
ASP A 123
ILE A  19
HIS A  82
 FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.3A)
 0.87A 2xadC-2awcA:
undetectable		 2xadC-2awcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 8 HIS A 101
ASP A 106
ILE A  21
HIS A  77
 FEO  A 115 (-3.4A)
FEO  A 115 (-2.6A)
None
FEO  A 115 (-3.4A)
 0.90A 2xadD-1hmdA:
undetectable		 2xadD-1hmdA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 HIS A 118
ASP A 123
ILE A  19
HIS A  82
 FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.3A)
 0.90A 2xadD-2awcA:
undetectable		 2xadD-2awcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 101
ASP A  79
 FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
None
 1.42A 2zweA-1hmdA:
undetectable
2zweB-1hmdA:
undetectable		 2zweA-1hmdA:
14.70
2zweB-1hmdA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.39A 2zweA-1hmdA:
undetectable
2zweB-1hmdA:
undetectable		 2zweA-1hmdA:
14.70
2zweB-1hmdA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
ILE A  28
HIS A  54
HIS A  77
HIS A 106
 FEO  A 119 ( 3.4A)
AZI  A 120 (-4.6A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.3A)
FEO  A 119 ( 3.3A)
 1.25A 2zweA-2mhrA:
undetectable
2zweB-2mhrA:
undetectable		 2zweA-2mhrA:
15.41
2zweB-2mhrA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.35A 2zwfA-1hmdA:
undetectable
2zwfB-1hmdA:
undetectable		 2zwfA-1hmdA:
14.70
2zwfB-1hmdA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.35A 2zwgA-1hmdA:
undetectable
2zwgB-1hmdA:
undetectable		 2zwgA-1hmdA:
14.70
2zwgB-1hmdA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.28A 3a6jA-1hmdA:
undetectable		 3a6jA-1hmdA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jA-2awcA:
undetectable		 3a6jA-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
ASP A 111
HIS A  73
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 2.5A)
FEO  A 119 (-3.5A)
None
FEO  A 119 ( 3.3A)
 1.30A 3a6jA-2mhrA:
undetectable		 3a6jA-2mhrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 8 GLU A  58
HIS A  25
ASP A 111
TRP A 102
HIS A  54
 FEO  A 119 (-2.5A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
None
FEO  A 119 ( 3.3A)
 1.17A 3a6jA-2mhrA:
undetectable		 3a6jA-2mhrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.29A 3a6jC-1hmdA:
undetectable		 3a6jC-1hmdA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
ASP A 123
HIS A  78
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-2.5A)
FEO  A 137 (-3.5A)
None
FEO  A 137 (-3.4A)
 1.40A 3a6jC-2awcA:
undetectable		 3a6jC-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jC-2awcA:
undetectable		 3a6jC-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.27A 3a6jE-1hmdA:
undetectable		 3a6jE-1hmdA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jE-2awcA:
undetectable		 3a6jE-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 8 GLU A  58
ASP A 106
HIS A  73
TRP A  97
HIS A  54
 FEO  A 115 (-2.5A)
FEO  A 115 (-2.6A)
FEO  A 115 (-3.4A)
None
FEO  A 115 (-3.5A)
 1.30A 3a6jF-1hmdA:
undetectable		 3a6jF-1hmdA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
ASP A 123
HIS A  78
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-2.5A)
FEO  A 137 (-3.5A)
None
FEO  A 137 (-3.4A)
 1.41A 3a6jF-2awcA:
undetectable		 3a6jF-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 8 GLU A  63
HIS A  23
ASP A 123
TRP A 114
HIS A  59
 FEO  A 137 (-2.6A)
FEO  A 137 (-3.3A)
FEO  A 137 (-2.5A)
None
FEO  A 137 (-3.4A)
 1.28A 3a6jF-2awcA:
undetectable		 3a6jF-2awcA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		5 / 12 TYR A 193
HIS A 226
ASP A  83
ASP A 165
SER A 299
 None
FEO  A 404 ( 3.2A)
FEO  A 404 (-2.2A)
FEO  A 404 ( 2.3A)
None
 1.37A 3b7pC-1e5dA:
undetectable		 3b7pC-1e5dA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 6 ASP A  83
LEU A  80
ASP A  49
LEU A  47
 FEO  A 404 (-2.2A)
None
None
None
 1.23A 3bj8C-1e5dA:
0.1
3bj8D-1e5dA:
0.0		 3bj8C-1e5dA:
18.09
3bj8D-1e5dA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 8 GLU A 273
TYR A  91
GLU A 194
ILE A 536
 FEO  A1595 ( 2.4A)
None
FEO  A1595 ( 2.5A)
None
 0.94A 3jz0B-4amfA:
undetectable		 3jz0B-4amfA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 10 TYR A   8
HIS A  25
ASP A 111
HIS A  54
ILE A  28
 None
FEO  A 119 ( 3.4A)
FEO  A 119 ( 2.5A)
FEO  A 119 ( 3.3A)
AZI  A 120 (-4.6A)
 1.47A 3kcxA-2mhrA:
undetectable		 3kcxA-2mhrA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 5 LEU A  21
HIS A 106
HIS A  73
HIS A  77
 None
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 (-3.3A)
 0.94A 3kecA-2mhrA:
undetectable		 3kecA-2mhrA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.98A 3ljgA-2awcA:
undetectable		 3ljgA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		3 / 3 SER A  29
ASP A  83
ASP A  49
 None
FEO  A 404 (-2.2A)
None
 0.79A 3uj7A-1e5dA:
undetectable		 3uj7A-1e5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W6H_A_AZMA303_1
(CARBONIC ANHYDRASE 1)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 8 GLN A  22
HIS A  59
HIS A  82
LEU A  66
 None
FEO  A 137 (-3.4A)
FEO  A 137 (-3.3A)
None
 1.05A 3w6hA-2awcA:
undetectable		 3w6hA-2awcA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 6 LEU A  21
HIS A 106
HIS A  73
HIS A  77
 None
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 (-3.3A)
 0.93A 4a7bA-2mhrA:
undetectable		 4a7bA-2mhrA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 12 TYR A  37
ASP A 167
ASP A  85
PHE A  24
HIS A  25
 None
FEO  A 501 ( 2.4A)
FEO  A 501 ( 2.4A)
EDO  A 602 (-3.8A)
EDO  A 602 ( 2.9A)
 1.32A 4b9zA-1ycgA:
undetectable		 4b9zA-1ycgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 11 HIS A 171
HIS A  23
GLU A  81
HIS A 227
TYR A  35
 PO4  A 503 (-4.5A)
PO4  A 503 ( 4.2A)
FEO  A 501 (-3.1A)
FEO  A 501 ( 3.3A)
None
 1.46A 4c2pA-5lmcA:
undetectable		 4c2pA-5lmcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 8 ASP A 494
ASP A  66
ASN A 195
GLU A 273
 CA  A1594 (-2.6A)
EDO  A1598 ( 3.7A)
ACP  A1589 (-3.4A)
FEO  A1595 ( 2.4A)
 1.01A 4feuD-4amfA:
undetectable		 4feuD-4amfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 12 TYR A 332
TYR A  33
GLU A  87
LEU A 204
LEU A 303
 None
None
FEO  A 701 (-2.9A)
None
None
 1.31A 4k36B-2q9uA:
undetectable		 4k36B-2q9uA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 11 TYR A 332
TYR A  33
GLU A  87
LEU A 204
LEU A 303
 None
None
FEO  A 701 (-2.9A)
None
None
 1.34A 4k37B-2q9uA:
undetectable		 4k37B-2q9uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 12 TYR A 332
TYR A  33
GLU A  87
LEU A 204
LEU A 303
 None
None
FEO  A 701 (-2.9A)
None
None
 1.31A 4k38B-2q9uA:
undetectable		 4k38B-2q9uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 12 TYR A 332
TYR A  33
GLU A  87
LEU A 204
LEU A 303
 None
None
FEO  A 701 (-2.9A)
None
None
 1.40A 4k39A-2q9uA:
undetectable		 4k39A-2q9uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 6 GLU A 194
GLU A 273
ARG A 385
GLU A 387
 FEO  A1595 ( 2.5A)
FEO  A1595 ( 2.4A)
ACP  A1589 (-2.8A)
CA  A1593 ( 2.3A)
 1.37A 4kr3A-4amfA:
undetectable		 4kr3A-4amfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		3 / 3 ASP A  85
VAL A  17
ASN A 166
 FEO  A 501 ( 2.4A)
None
None
 0.81A 4lmnA-1ycgA:
undetectable		 4lmnA-1ycgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		3 / 3 ASP A  89
VAL A  23
ASN A 170
 FEO  A 701 ( 2.4A)
None
None
 0.78A 4lmnA-2q9uA:
undetectable		 4lmnA-2q9uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 5 GLN A 190
THR A  29
HIS A 147
LEU A 199
 None
None
FEO  A 501 ( 3.4A)
None
 1.02A 4lvcA-5lmcA:
5.3		 4lvcA-5lmcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 5 GLN A 190
THR A  29
HIS A 147
LEU A 199
 None
None
FEO  A 501 ( 3.4A)
None
 1.03A 4lvcC-5lmcA:
undetectable		 4lvcC-5lmcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 6 ASN A  68
GLU A  90
TYR A  91
GLU A 532
 None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
 1.27A 4mi4A-4amfA:
undetectable		 4mi4A-4amfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 7 ASN A  68
GLU A  90
TYR A  91
GLU A 532
 None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
 1.29A 4mi4A-4amfA:
undetectable
4mi4C-4amfA:
undetectable		 4mi4A-4amfA:
16.49
4mi4C-4amfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 7 ASN A  68
GLU A  90
TYR A  91
GLU A 532
 None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
 1.28A 4mj8C-4amfA:
undetectable		 4mj8C-4amfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		3 / 3 SER A  29
ASP A  83
ASP A  49
 None
FEO  A 404 (-2.2A)
None
 0.77A 4mwzA-1e5dA:
undetectable		 4mwzA-1e5dA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 7 HIS A  73
HIS A 101
HIS A  25
HIS A  54
 FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
 0.81A 4p6sA-1hmdA:
undetectable		 4p6sA-1hmdA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.83A 4p6sA-2awcA:
undetectable		 4p6sA-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 7 HIS A  73
HIS A 106
HIS A  25
HIS A  54
 FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
 0.92A 4p6sA-2mhrA:
undetectable		 4p6sA-2mhrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 7 HIS A  73
HIS A 101
HIS A  25
HIS A  54
 FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
 0.79A 4p6sB-1hmdA:
undetectable		 4p6sB-1hmdA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 7 HIS A  25
HIS A 148
HIS A  86
ASN A 166
HIS A 228
 EDO  A 602 ( 2.9A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
None
FEO  A 501 ( 3.1A)
 1.30A 4p6sB-1ycgA:
undetectable		 4p6sB-1ycgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.83A 4p6sB-2awcA:
undetectable		 4p6sB-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 7 HIS A  73
HIS A 106
HIS A  25
HIS A  54
 FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
 0.89A 4p6sB-2mhrA:
undetectable		 4p6sB-2mhrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 6 HIS A  54
HIS A  25
TYR A 114
GLU A  58
 FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
None
FEO  A 119 (-2.5A)
 1.10A 4pahA-2mhrA:
undetectable		 4pahA-2mhrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4amf PHOX
(Pseudomonas
fluorescens) 		5 / 12 VAL A 390
ASN A 274
GLY A 480
ASP A 479
ASP A 292
 EDO  A1597 (-3.8A)
None
None
CA  A1592 (-2.1A)
FEO  A1595 ( 3.1A)
 1.35A 4pevB-4amfA:
undetectable		 4pevB-4amfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 8 PHE A 475
THR A 403
GLU A 194
ASP A 292
 None
CA  A1593 ( 4.5A)
FEO  A1595 ( 2.5A)
FEO  A1595 ( 3.1A)
 1.13A 4qb9D-4amfA:
undetectable		 4qb9D-4amfA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 5 TYR A  26
SER A  20
ASP A  83
ASP A  49
 None
None
FEO  A 404 (-2.2A)
None
 1.24A 4qtuB-1e5dA:
2.2		 4qtuB-1e5dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3chi P-AMINOBENZOATE
N-OXYGENASE
(Streptomyces
thioluteus) 		4 / 7 GLY A 192
ALA A 193
GLU A 196
THR A 197
 None
None
FEO  A 501 (-2.1A)
None
 0.65A 4r1zB-3chiA:
2.0		 4r1zB-3chiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 7 ASN A  68
GLU A  90
TYR A  91
GLU A 532
 None
FEO  A1595 ( 2.6A)
None
CA  A1594 (-2.3A)
 1.30A 4r87I-4amfA:
undetectable		 4r87I-4amfA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4amf PHOX
(Pseudomonas
fluorescens) 		5 / 12 ASN A 195
ASP A 479
GLU A 194
GLU A 273
THR A 534
 ACP  A1589 (-3.4A)
CA  A1592 (-2.1A)
FEO  A1595 ( 2.5A)
FEO  A1595 ( 2.4A)
None
 1.45A 4zjoA-4amfA:
undetectable		 4zjoA-4amfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4amf PHOX
(Pseudomonas
fluorescens) 		5 / 12 ASN A 195
ASP A 479
GLU A 273
GLU A 194
GLU A 387
 ACP  A1589 (-3.4A)
CA  A1592 (-2.1A)
FEO  A1595 ( 2.4A)
FEO  A1595 ( 2.5A)
CA  A1593 ( 2.3A)
 1.48A 4zjoA-4amfA:
undetectable		 4zjoA-4amfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 7 HIS A 230
GLY A 172
ASN A 170
HIS A 152
 FEO  A 701 ( 3.3A)
None
None
FEO  A 701 ( 3.4A)
 1.23A 5a5zC-2q9uA:
17.3		 5a5zC-2q9uA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 VAL A  86
PHE A  60
HIS A  59
GLU A  58
 None
FEO  A 137 ( 4.8A)
FEO  A 137 (-3.4A)
None
 1.06A 5ad9A-2awcA:
2.4
5ad9B-2awcA:
2.2		 5ad9A-2awcA:
16.75
5ad9B-2awcA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		4 / 8 SER A 152
ALA A 144
HIS A  81
LEU A 200
 None
None
FEO  A 501 (-3.3A)
None
 1.01A 5dzkF-1ycgA:
undetectable
5dzkT-1ycgA:
undetectable		 5dzkF-1ycgA:
22.19
5dzkT-1ycgA:
0.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		4 / 4 ALA A  28
PRO A 202
LEU A 147
HIS A 148
 None
None
None
FEO  A 501 (-2.8A)
 1.27A 5eskA-1ycgA:
undetectable		 5eskA-1ycgA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 7 HIS A  73
HIS A 101
HIS A  25
HIS A  54
 FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
 0.82A 5i3aA-1hmdA:
undetectable		 5i3aA-1hmdA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 7 HIS A  25
HIS A 148
HIS A  86
ASN A 166
HIS A 228
 EDO  A 602 ( 2.9A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
None
FEO  A 501 ( 3.1A)
 1.32A 5i3aA-1ycgA:
undetectable		 5i3aA-1ycgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.85A 5i3aA-2awcA:
undetectable		 5i3aA-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 7 HIS A  73
HIS A 101
HIS A  25
HIS A  54
 FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
 0.80A 5i3aB-1hmdA:
undetectable		 5i3aB-1hmdA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 7 HIS A  25
HIS A 148
HIS A  86
ASN A 166
HIS A 228
 EDO  A 602 ( 2.9A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
None
FEO  A 501 ( 3.1A)
 1.29A 5i3aB-1ycgA:
undetectable		 5i3aB-1ycgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.84A 5i3aB-2awcA:
undetectable		 5i3aB-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 7 HIS A  73
HIS A 106
HIS A  25
HIS A  54
 FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
 0.92A 5i3aB-2mhrA:
undetectable		 5i3aB-2mhrA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 7 HIS A  73
HIS A 101
HIS A  25
HIS A  54
 FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
 0.89A 5i3bA-1hmdA:
undetectable		 5i3bA-1hmdA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 7 HIS A  25
HIS A 148
HIS A  86
ASN A 166
HIS A 228
 EDO  A 602 ( 2.9A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
None
FEO  A 501 ( 3.1A)
 1.33A 5i3bA-1ycgA:
undetectable		 5i3bA-1ycgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 7 HIS A  78
HIS A 118
HIS A  23
HIS A  59
 FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.4A)
 0.92A 5i3bA-2awcA:
undetectable		 5i3bA-2awcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 11 GLN A 170
ASN A  36
ASP A  83
TYR A 194
LEU A 199
 None
None
FEO  A 501 ( 2.5A)
None
None
 1.48A 5jh7B-5lmcA:
5.1		 5jh7B-5lmcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 5 ILE A  21
HIS A  73
HIS A  77
HIS A 101
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.00A 5n5kA-1hmdA:
undetectable		 5n5kA-1hmdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 5 ILE A  21
HIS A  77
HIS A 101
HIS A  73
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.75A 5n5kA-1hmdA:
undetectable		 5n5kA-1hmdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 5 ILE A  21
HIS A 101
HIS A  73
HIS A  77
 None
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 0.92A 5n5kA-1hmdA:
undetectable		 5n5kA-1hmdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A  78
HIS A  82
HIS A 118
 None
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 0.91A 5n5kA-2awcA:
undetectable		 5n5kA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A  82
HIS A 118
HIS A  78
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
 0.83A 5n5kA-2awcA:
undetectable		 5n5kA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		4 / 5 ILE A  19
HIS A 118
HIS A  78
HIS A  82
 None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.5A)
FEO  A 137 (-3.3A)
 0.84A 5n5kA-2awcA:
undetectable		 5n5kA-2awcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 5 ILE A 198
GLU A  81
HIS A  84
HIS A 227
 PO4  A 503 (-4.6A)
FEO  A 501 (-3.1A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.3A)
 1.00A 5n5kA-5lmcA:
2.4		 5n5kA-5lmcA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A 168
HIS A  90
HIS A 228
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.83A 5ncdA-1vmeA:
undetectable
5ncdD-1vmeA:
undetectable		 5ncdA-1vmeA:
20.59
5ncdD-1vmeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 6 ASP A 167
HIS A  86
HIS A 228
HIS A 148
HIS A  25
 FEO  A 501 ( 2.4A)
FEO  A 501 (-3.1A)
FEO  A 501 ( 3.1A)
FEO  A 501 (-2.8A)
EDO  A 602 ( 2.9A)
 1.11A 5ncdA-1ycgA:
undetectable
5ncdD-1ycgA:
undetectable		 5ncdA-1ycgA:
22.25
5ncdD-1ycgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 ASP A 171
HIS A  90
HIS A 230
HIS A 152
HIS A  31
 FEO  A 701 ( 2.5A)
FEO  A 701 (-3.3A)
FEO  A 701 ( 3.3A)
FEO  A 701 ( 3.4A)
NO3  A 501 (-3.9A)
 1.25A 5ncdA-2q9uA:
undetectable
5ncdD-2q9uA:
undetectable		 5ncdA-2q9uA:
22.38
5ncdD-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 6 ASP A 171
HIS A 152
HIS A  85
HIS A 230
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
FEO  A 701 (-3.5A)
FEO  A 701 ( 3.3A)
 0.95A 5ncdA-2q9uA:
undetectable
5ncdD-2q9uA:
undetectable		 5ncdA-2q9uA:
22.38
5ncdD-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 ASP A 171
HIS A 230
HIS A 176
HIS A 152
HIS A  31
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.3A)
NO3  A 501 (-4.8A)
FEO  A 701 ( 3.4A)
NO3  A 501 (-3.9A)
 1.38A 5ncdA-2q9uA:
undetectable
5ncdD-2q9uA:
undetectable		 5ncdA-2q9uA:
22.38
5ncdD-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 ASP A 166
HIS A  84
HIS A 227
HIS A 147
HIS A  23
 FEO  A 501 ( 2.5A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.3A)
FEO  A 501 ( 3.4A)
PO4  A 503 ( 4.2A)
 1.20A 5ncdA-5lmcA:
undetectable
5ncdD-5lmcA:
undetectable		 5ncdA-5lmcA:
19.42
5ncdD-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 ASP A 166
HIS A 227
HIS A 171
HIS A 147
HIS A  23
 FEO  A 501 ( 2.5A)
FEO  A 501 ( 3.3A)
PO4  A 503 (-4.5A)
FEO  A 501 ( 3.4A)
PO4  A 503 ( 4.2A)
 1.13A 5ncdA-5lmcA:
undetectable
5ncdD-5lmcA:
undetectable		 5ncdA-5lmcA:
19.42
5ncdD-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A 168
HIS A  90
HIS A 228
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.87A 5ncdB-1vmeA:
undetectable
5ncdC-1vmeA:
undetectable		 5ncdB-1vmeA:
20.59
5ncdC-1vmeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 6 HIS A  25
ASP A 167
HIS A  86
HIS A 228
HIS A 148
 EDO  A 602 ( 2.9A)
FEO  A 501 ( 2.4A)
FEO  A 501 (-3.1A)
FEO  A 501 ( 3.1A)
FEO  A 501 (-2.8A)
 1.12A 5ncdB-1ycgA:
undetectable
5ncdC-1ycgA:
undetectable		 5ncdB-1ycgA:
22.25
5ncdC-1ycgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 6 ASP A 171
HIS A 152
HIS A  85
HIS A 230
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
FEO  A 701 (-3.5A)
FEO  A 701 ( 3.3A)
 0.92A 5ncdB-2q9uA:
undetectable
5ncdC-2q9uA:
undetectable		 5ncdB-2q9uA:
22.38
5ncdC-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 HIS A  31
ASP A 171
HIS A  90
HIS A 230
HIS A 152
 NO3  A 501 (-3.9A)
FEO  A 701 ( 2.5A)
FEO  A 701 (-3.3A)
FEO  A 701 ( 3.3A)
FEO  A 701 ( 3.4A)
 1.28A 5ncdB-2q9uA:
undetectable
5ncdC-2q9uA:
undetectable		 5ncdB-2q9uA:
22.38
5ncdC-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 HIS A  31
ASP A 171
HIS A 230
HIS A 176
HIS A 152
 NO3  A 501 (-3.9A)
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.3A)
NO3  A 501 (-4.8A)
FEO  A 701 ( 3.4A)
 1.44A 5ncdB-2q9uA:
undetectable
5ncdC-2q9uA:
undetectable		 5ncdB-2q9uA:
22.38
5ncdC-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 HIS A  23
ASP A 166
HIS A  84
HIS A 227
HIS A 147
 PO4  A 503 ( 4.2A)
FEO  A 501 ( 2.5A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.3A)
FEO  A 501 ( 3.4A)
 1.22A 5ncdB-5lmcA:
undetectable
5ncdC-5lmcA:
undetectable		 5ncdB-5lmcA:
19.42
5ncdC-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 HIS A  23
ASP A 166
HIS A 227
HIS A 171
HIS A 147
 PO4  A 503 ( 4.2A)
FEO  A 501 ( 2.5A)
FEO  A 501 ( 3.3A)
PO4  A 503 (-4.5A)
FEO  A 501 ( 3.4A)
 1.15A 5ncdB-5lmcA:
undetectable
5ncdC-5lmcA:
undetectable		 5ncdB-5lmcA:
19.42
5ncdC-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		4 / 4 ASP A 167
HIS A 228
HIS A 172
HIS A 148
 FEO  A 501 ( 2.4A)
FEO  A 501 ( 3.1A)
None
FEO  A 501 (-2.8A)
 1.05A 5ncdD-1ycgA:
undetectable		 5ncdD-1ycgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 ASP A 165
HIS A 146
HIS A  79
HIS A 226
 FEO  A 404 ( 2.3A)
FEO  A 404 (-3.3A)
FEO  A 404 (-3.3A)
FEO  A 404 ( 3.2A)
 0.97A 5nekB-1e5dA:
undetectable		 5nekB-1e5dA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		4 / 8 ASP A 167
HIS A 148
HIS A  81
HIS A 228
 FEO  A 501 ( 2.4A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.3A)
FEO  A 501 ( 3.1A)
 1.01A 5nekB-1ycgA:
undetectable		 5nekB-1ycgA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 8 ASP A 171
HIS A 152
HIS A  85
HIS A 230
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
FEO  A 701 (-3.5A)
FEO  A 701 ( 3.3A)
 0.97A 5nekB-2q9uA:
undetectable		 5nekB-2q9uA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 8 ASP A 166
HIS A  84
HIS A 227
HIS A 147
 FEO  A 501 ( 2.5A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.3A)
FEO  A 501 ( 3.4A)
 0.94A 5nekB-5lmcA:
undetectable		 5nekB-5lmcA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 8 ASP A 166
HIS A 147
HIS A  79
HIS A 227
 FEO  A 501 ( 2.5A)
FEO  A 501 ( 3.4A)
FEO  A 501 (-3.3A)
FEO  A 501 ( 3.3A)
 1.00A 5nekB-5lmcA:
undetectable		 5nekB-5lmcA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1e5d RUBREDOXIN:OXYGEN
OXIDOREDUCTASE
(Desulfovibrio
gigas) 		4 / 8 ASP A 165
HIS A 146
HIS A  79
HIS A 226
 FEO  A 404 ( 2.3A)
FEO  A 404 (-3.3A)
FEO  A 404 (-3.3A)
FEO  A 404 ( 3.2A)
 0.93A 5nekD-1e5dA:
undetectable		 5nekD-1e5dA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 8 ASP A 171
HIS A 152
HIS A  85
HIS A 230
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
FEO  A 701 (-3.5A)
FEO  A 701 ( 3.3A)
 0.92A 5nekD-2q9uA:
undetectable		 5nekD-2q9uA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A 168
HIS A  90
HIS A 228
HIS A 151
 FEO  A 401 (-2.5A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.3A)
FEO  A 401 (-3.5A)
 0.83A 5nelA-1vmeA:
undetectable
5nelD-1vmeA:
undetectable		 5nelA-1vmeA:
20.59
5nelD-1vmeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 6 ASP A 167
HIS A  86
HIS A 228
HIS A 148
HIS A  25
 FEO  A 501 ( 2.4A)
FEO  A 501 (-3.1A)
FEO  A 501 ( 3.1A)
FEO  A 501 (-2.8A)
EDO  A 602 ( 2.9A)
 1.10A 5nelA-1ycgA:
undetectable
5nelD-1ycgA:
undetectable		 5nelA-1ycgA:
22.25
5nelD-1ycgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 6 ASP A 167
HIS A 228
HIS A 172
HIS A 148
HIS A  25
 FEO  A 501 ( 2.4A)
FEO  A 501 ( 3.1A)
None
FEO  A 501 (-2.8A)
EDO  A 602 ( 2.9A)
 1.28A 5nelA-1ycgA:
undetectable
5nelD-1ycgA:
undetectable		 5nelA-1ycgA:
22.25
5nelD-1ycgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 ASP A 171
HIS A  90
HIS A 230
HIS A 152
HIS A  31
 FEO  A 701 ( 2.5A)
FEO  A 701 (-3.3A)
FEO  A 701 ( 3.3A)
FEO  A 701 ( 3.4A)
NO3  A 501 (-3.9A)
 1.28A 5nelA-2q9uA:
2.6
5nelD-2q9uA:
undetectable		 5nelA-2q9uA:
22.38
5nelD-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 6 ASP A 171
HIS A 152
HIS A  85
HIS A 230
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
FEO  A 701 (-3.5A)
FEO  A 701 ( 3.3A)
 0.92A 5nelA-2q9uA:
2.6
5nelD-2q9uA:
undetectable		 5nelA-2q9uA:
22.38
5nelD-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 ASP A 171
HIS A 230
HIS A 176
HIS A 152
HIS A  31
 FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.3A)
NO3  A 501 (-4.8A)
FEO  A 701 ( 3.4A)
NO3  A 501 (-3.9A)
 1.44A 5nelA-2q9uA:
2.6
5nelD-2q9uA:
undetectable		 5nelA-2q9uA:
22.38
5nelD-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 ASP A 166
HIS A  84
HIS A 227
HIS A 147
HIS A  23
 FEO  A 501 ( 2.5A)
FEO  A 501 (-3.2A)
FEO  A 501 ( 3.3A)
FEO  A 501 ( 3.4A)
PO4  A 503 ( 4.2A)
 1.19A 5nelA-5lmcA:
undetectable
5nelD-5lmcA:
undetectable		 5nelA-5lmcA:
19.42
5nelD-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 ASP A 166
HIS A 227
HIS A 171
HIS A 147
HIS A  23
 FEO  A 501 ( 2.5A)
FEO  A 501 ( 3.3A)
PO4  A 503 (-4.5A)
FEO  A 501 ( 3.4A)
PO4  A 503 ( 4.2A)
 1.11A 5nelA-5lmcA:
undetectable
5nelD-5lmcA:
undetectable		 5nelA-5lmcA:
19.42
5nelD-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		4 / 6 ASP A 167
HIS A 228
HIS A 172
HIS A 148
 FEO  A 501 ( 2.4A)
FEO  A 501 ( 3.1A)
None
FEO  A 501 (-2.8A)
 1.01A 5nelB-1ycgA:
undetectable
5nelC-1ycgA:
undetectable		 5nelB-1ycgA:
22.25
5nelC-1ycgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		5 / 6 HIS A  31
ASP A 171
HIS A 230
HIS A 176
HIS A 152
 NO3  A 501 (-3.9A)
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.3A)
NO3  A 501 (-4.8A)
FEO  A 701 ( 3.4A)
 1.45A 5nelB-2q9uA:
undetectable
5nelC-2q9uA:
undetectable		 5nelB-2q9uA:
22.38
5nelC-2q9uA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 6 HIS A  23
ASP A 166
HIS A 227
HIS A 171
HIS A 147
 PO4  A 503 ( 4.2A)
FEO  A 501 ( 2.5A)
FEO  A 501 ( 3.3A)
PO4  A 503 (-4.5A)
FEO  A 501 ( 3.4A)
 1.19A 5nelB-5lmcA:
undetectable
5nelC-5lmcA:
undetectable		 5nelB-5lmcA:
19.42
5nelC-5lmcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 12 ASP A 111
ILE A 107
PHE A  55
LEU A  81
HIS A  54
 FEO  A 119 ( 2.5A)
AZI  A 120 (-4.7A)
AZI  A 120 (-4.5A)
None
FEO  A 119 ( 3.3A)
 1.45A 5nn8A-2mhrA:
undetectable		 5nn8A-2mhrA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		3 / 3 HIS A  86
HIS A  81
HIS A 148
 FEO  A 501 (-3.1A)
FEO  A 501 (-3.3A)
FEO  A 501 (-2.8A)
 0.95A 5oexA-1ycgA:
undetectable		 5oexA-1ycgA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 4 HIS A  54
HIS A  25
TYR A 109
GLU A  58
 FEO  A 115 (-3.5A)
FEO  A 115 (-3.3A)
None
FEO  A 115 (-2.5A)
 1.20A 5pahA-1hmdA:
undetectable		 5pahA-1hmdA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		4 / 4 HIS A  54
HIS A  25
TYR A 114
GLU A  58
 FEO  A 119 ( 3.3A)
FEO  A 119 ( 3.4A)
None
FEO  A 119 (-2.5A)
 1.10A 5pahA-2mhrA:
undetectable		 5pahA-2mhrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 4 VAL A 148
LEU A 215
ASN A 170
ASP A 171
 None
None
None
FEO  A 701 ( 2.5A)
 1.02A 5vcyA-2q9uA:
undetectable		 5vcyA-2q9uA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 11 ALA A 224
ASP A 166
SER A 226
ILE A  77
ASN A  78
 None
FEO  A 501 ( 2.5A)
FEO  A 501 ( 4.3A)
None
None
 1.34A 5y80A-5lmcA:
undetectable		 5y80A-5lmcA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 101
ASP A  79
 FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
None
 1.36A 5z0fA-1hmdA:
undetectable
5z0fB-1hmdA:
undetectable		 5z0fA-1hmdA:
20.69
5z0fB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  73
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.34A 5z0fA-1hmdA:
undetectable
5z0fB-1hmdA:
undetectable		 5z0fA-1hmdA:
20.69
5z0fB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.38A 5z0fA-1hmdA:
undetectable
5z0fB-1hmdA:
undetectable		 5z0fA-1hmdA:
20.69
5z0fB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 11 HIS A  25
ILE A 199
HIS A 148
HIS A  86
HIS A 228
 EDO  A 602 ( 2.9A)
EDO  A 602 ( 4.6A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
FEO  A 501 ( 3.1A)
 1.01A 5z0fA-1ycgA:
undetectable
5z0fB-1ycgA:
undetectable		 5z0fA-1ycgA:
13.66
5z0fB-1ycgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 106
ASP A  79
 FEO  A 119 ( 3.4A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.5A)
FEO  A 119 ( 3.3A)
None
 1.43A 5z0fA-2mhrA:
undetectable
5z0fB-2mhrA:
undetectable		 5z0fA-2mhrA:
16.80
5z0fB-2mhrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		5 / 11 HIS A  23
ILE A 198
HIS A 147
HIS A 227
HIS A 171
 PO4  A 503 ( 4.2A)
PO4  A 503 (-4.6A)
FEO  A 501 ( 3.4A)
FEO  A 501 ( 3.3A)
PO4  A 503 (-4.5A)
 1.37A 5z0fA-5lmcA:
undetectable
5z0fB-5lmcA:
undetectable		 5z0fA-5lmcA:
10.30
5z0fB-5lmcA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 101
ASP A  79
 FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
None
 1.41A 5z0gA-1hmdA:
undetectable
5z0gB-1hmdA:
undetectable		 5z0gA-1hmdA:
20.69
5z0gB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  73
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.33A 5z0gA-1hmdA:
undetectable
5z0gB-1hmdA:
undetectable		 5z0gA-1hmdA:
20.69
5z0gB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.37A 5z0gA-1hmdA:
undetectable
5z0gB-1hmdA:
undetectable		 5z0gA-1hmdA:
20.69
5z0gB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 11 HIS A  25
ILE A 199
HIS A 148
HIS A  86
ASN A 166
 EDO  A 602 ( 2.9A)
EDO  A 602 ( 4.6A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
None
 1.47A 5z0gA-1ycgA:
undetectable
5z0gB-1ycgA:
undetectable		 5z0gA-1ycgA:
13.66
5z0gB-1ycgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		5 / 11 HIS A  25
ILE A 199
HIS A 148
HIS A  86
HIS A 228
 EDO  A 602 ( 2.9A)
EDO  A 602 ( 4.6A)
FEO  A 501 (-2.8A)
FEO  A 501 (-3.1A)
FEO  A 501 ( 3.1A)
 1.01A 5z0gA-1ycgA:
undetectable
5z0gB-1ycgA:
undetectable		 5z0gA-1ycgA:
13.66
5z0gB-1ycgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 11 HIS A  59
ILE A  19
HIS A  23
HIS A 118
HIS A  82
 FEO  A 137 (-3.4A)
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 1.39A 5z0gA-2awcA:
undetectable
5z0gB-2awcA:
undetectable		 5z0gA-2awcA:
20.00
5z0gB-2awcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
ILE A  28
HIS A  54
HIS A  77
HIS A 106
 FEO  A 119 ( 3.4A)
AZI  A 120 (-4.6A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.3A)
FEO  A 119 ( 3.3A)
 1.20A 5z0gA-2mhrA:
undetectable
5z0gB-2mhrA:
undetectable		 5z0gA-2mhrA:
16.80
5z0gB-2mhrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.35A 5z0hA-1hmdA:
undetectable
5z0hB-1hmdA:
undetectable		 5z0hA-1hmdA:
20.69
5z0hB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 101
ASP A  79
 FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
None
 1.47A 5z0iA-1hmdA:
undetectable
5z0iB-1hmdA:
undetectable		 5z0iA-1hmdA:
20.69
5z0iB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  73
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.34A 5z0iA-1hmdA:
undetectable
5z0iB-1hmdA:
undetectable		 5z0iA-1hmdA:
20.69
5z0iB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.36A 5z0iA-1hmdA:
undetectable
5z0iB-1hmdA:
undetectable		 5z0iA-1hmdA:
20.69
5z0iB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 11 HIS A  59
ILE A  19
HIS A  23
HIS A 118
HIS A  82
 FEO  A 137 (-3.4A)
None
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
FEO  A 137 (-3.3A)
 1.39A 5z0iA-2awcA:
undetectable
5z0iB-2awcA:
undetectable		 5z0iA-2awcA:
20.00
5z0iB-2awcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 2mhr MYOHEMERYTHRIN
(Themiste
hennahi) 		5 / 11 HIS A  25
ILE A  28
HIS A  54
HIS A  77
HIS A 106
 FEO  A 119 ( 3.4A)
AZI  A 120 (-4.6A)
FEO  A 119 ( 3.3A)
FEO  A 119 (-3.3A)
FEO  A 119 ( 3.3A)
 1.21A 5z0iA-2mhrA:
undetectable
5z0iB-2mhrA:
undetectable		 5z0iA-2mhrA:
16.80
5z0iB-2mhrA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 101
ASP A  79
 FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
None
 1.41A 5z0jA-1hmdA:
undetectable
5z0jB-1hmdA:
undetectable		 5z0jA-1hmdA:
20.69
5z0jB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.39A 5z0jA-1hmdA:
undetectable
5z0jB-1hmdA:
undetectable		 5z0jA-1hmdA:
20.69
5z0jB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  25
HIS A  54
HIS A  73
HIS A 101
ASP A  79
 FEO  A 115 (-3.3A)
FEO  A 115 (-3.5A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
None
 1.45A 5z0kA-1hmdA:
undetectable
5z0kB-1hmdA:
undetectable		 5z0kA-1hmdA:
20.69
5z0kB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.37A 5z0kA-1hmdA:
undetectable
5z0kB-1hmdA:
undetectable		 5z0kA-1hmdA:
20.69
5z0kB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.34A 5z0lA-1hmdA:
undetectable
5z0lB-1hmdA:
undetectable		 5z0lA-1hmdA:
20.69
5z0lB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		5 / 11 HIS A  54
ILE A  21
HIS A  25
HIS A 101
HIS A  77
 FEO  A 115 (-3.5A)
None
FEO  A 115 (-3.3A)
FEO  A 115 (-3.4A)
FEO  A 115 (-3.4A)
 1.34A 5z0mA-1hmdA:
undetectable
5z0mB-1hmdA:
undetectable		 5z0mA-1hmdA:
19.83
5z0mB-1hmdA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4amf PHOX
(Pseudomonas
fluorescens) 		4 / 6 SER A 477
ASP A 292
GLU A 273
THR A 534
 None
FEO  A1595 ( 3.1A)
FEO  A1595 ( 2.4A)
None
 1.31A 6djzA-4amfA:
undetectable		 6djzA-4amfA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1hmd HEMERYTHRIN
(Themiste
dyscritum) 		4 / 6 TRP A  97
LEU A  56
ASP A 106
GLU A  58
 None
None
FEO  A 115 (-2.6A)
FEO  A 115 (-2.5A)
 1.39A 6djzC-1hmdA:
undetectable		 6djzC-1hmdA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1vme FLAVOPROTEIN
(Thermotoga
maritima) 		3 / 3 TYR A  40
HIS A 228
PHE A  28
 None
FEO  A 401 (-3.3A)
None
 1.05A 6esmA-1vmeA:
2.8		 6esmA-1vmeA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1ycg NITRIC OXIDE
REDUCTASE
(Moorella
thermoacetica) 		3 / 3 TYR A  37
HIS A 228
PHE A  24
 None
FEO  A 501 ( 3.1A)
EDO  A 602 (-3.8A)
 0.74A 6esmA-1ycgA:
undetectable		 6esmA-1ycgA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		3 / 3 TYR A  41
HIS A 230
PHE A  30
 None
FEO  A 701 ( 3.3A)
NO3  A 501 (-4.7A)
 0.98A 6esmA-2q9uA:
2.3		 6esmA-2q9uA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		3 / 3 TYR A  35
HIS A 227
PHE A  22
 None
FEO  A 501 ( 3.3A)
PO4  A 503 ( 4.9A)
 1.03A 6esmA-5lmcA:
2.6		 6esmA-5lmcA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 5 GLN A 190
THR A  29
HIS A 147
LEU A 199
 None
None
FEO  A 501 ( 3.4A)
None
 1.03A 6gbnA-5lmcA:
5.0		 6gbnA-5lmcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN
(Escherichia
coli) 		4 / 5 GLN A 190
THR A  29
HIS A 147
LEU A 199
 None
None
FEO  A 501 ( 3.4A)
None
 1.02A 6gbnD-5lmcA:
5.0		 6gbnD-5lmcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 8 TRP A 234
ASP A 171
HIS A 152
GLU A 198
 None
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
None
 1.25A 6mn4B-2q9uA:
undetectable		 6mn4B-2q9uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2q9u A-TYPE FLAVOPROTEIN
(Giardia
intestinalis) 		4 / 8 TRP A 234
ASP A 171
HIS A 152
GLU A 198
 None
FEO  A 701 ( 2.5A)
FEO  A 701 ( 3.4A)
None
 1.19A 6mn4D-2q9uA:
undetectable		 6mn4D-2q9uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 2awc HEMERYTHRIN-LIKE
DOMAIN PROTEIN DCRH
(Desulfovibrio
vulgaris) 		5 / 12 PHE A  85
ASN A  15
LEU A  16
PHE A  60
TYR A  72
 None
None
None
FEO  A 137 ( 4.8A)
None
 1.25A 6r2eA-2awcA:
undetectable		 6r2eA-2awcA:
15.71