SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FEG'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FSL_A_NIOA145_1 (LEGHEMOGLOBIN A)	3daf	5,10-METHENYLTETRAHY DROMETHANOPTERIN HYDROGENASE (Methanocaldococc us jannaschii)	5 / 8	PHE A 162 ILE A 166 PHE A 183 LEU A 6 VAL A 139	None None None FEG A 501 (-4.1A) None	1.34A	1fslA-3dafA: undetectable	1fslA-3dafA: 18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QHS_A_CLMA999_0 (PROTEIN (CHLORAMPHENICOL PHOSPHOTRANSFERASE))	3daf	5,10-METHENYLTETRAHY DROMETHANOPTERIN HYDROGENASE (Methanocaldococc us jannaschii)	6 / 12	SER A 63 VAL A 145 ILE A 166 ILE A 159 PHE A 187 LEU A 149	FEG A 501 (-4.4A) None None None None FEG A 501 (-4.9A)	1.37A	1qhsA-3dafA: undetectable	1qhsA-3dafA: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LB3_A_4CHA191_0 (DEHALOPEROXIDASE A)	5ok4	5,10-METHENYLTETRAHY DROMETHANOPTERIN HYDROGENASE (Methanothermobac ter marburgensis)	4 / 6	PHE A 145 HIS A 170 THR A 169 VAL A 168	FEG A 404 (-4.9A) None None None	1.23A	3lb3A-5ok4A: undetectable	3lb3A-5ok4A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_C_CVIC301_0 (REGULATORY PROTEIN TETR)	5ok4	5,10-METHENYLTETRAHY DROMETHANOPTERIN HYDROGENASE (Methanothermobac ter marburgensis)	5 / 12	ALA A 62 GLU A 121 TYR A 202 VAL A 59 ASP A 122	FEG A 404 (-4.2A) None None None None	1.38A	5vlmC-5ok4A: undetectable	5vlmC-5ok4A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_A_TLFA300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	5ok4	5,10-METHENYLTETRAHY DROMETHANOPTERIN HYDROGENASE (Methanothermobac ter marburgensis)	5 / 12	PHE A 70 ILE A 127 VAL A 65 PHE A 66 HIS A 41	None None FEG A 404 ( 4.9A) None None	1.08A	6ap6A-5ok4A: undetectable	6ap6A-5ok4A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_B_TLFB300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	5ok4	5,10-METHENYLTETRAHY DROMETHANOPTERIN HYDROGENASE (Methanothermobac ter marburgensis)	5 / 12	PHE A 70 ILE A 127 VAL A 65 PHE A 66 HIS A 41	None None FEG A 404 ( 4.9A) None None	1.07A	6ap6B-5ok4A: undetectable	6ap6B-5ok4A: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FSL_A_NIOA145_1","LEGHEMOGLOBIN A","3daf","5,10-METHENYLTETRAHYDROMETHANOPTERIN HYDROGENASE","Methanocaldococcus jannaschii",5,"PHE A 162;ILE A 166;PHE A 183;LEU A   6;VAL A 139","None;None;None;FEG A 501 (-4.1A);None","1.34A","1fslA-3dafA:undetectable",null],["1QHS_A_CLMA999_0","PROTEIN (CHLORAMPHENICOL PHOSPHOTRANSFERASE)","3daf","5,10-METHENYLTETRAHYDROMETHANOPTERIN HYDROGENASE","Methanocaldococcus jannaschii",6,"SER A  63;VAL A 145;ILE A 166;ILE A 159;PHE A 187;LEU A 149","FEG A 501 (-4.4A);None;None;None;None;FEG A 501 (-4.9A)","1.37A","1qhsA-3dafA:undetectable","1fslA-3dafA:18.13"],["3LB3_A_4CHA191_0","DEHALOPEROXIDASE A","5ok4","5,10-METHENYLTETRAHYDROMETHANOPTERIN HYDROGENASE","Methanothermobacter marburgensis",4,"PHE A 145;HIS A 170;THR A 169;VAL A 168","FEG A 404 (-4.9A);None;None;None","1.23A","3lb3A-5ok4A:undetectable","1qhsA-3dafA:21.22"],["5VLM_C_CVIC301_0","REGULATORY PROTEIN TETR","5ok4","5,10-METHENYLTETRAHYDROMETHANOPTERIN HYDROGENASE","Methanothermobacter marburgensis",5,"ALA A  62;GLU A 121;TYR A 202;VAL A  59;ASP A 122","FEG A 404 (-4.2A);None;None;None;None","1.38A","5vlmC-5ok4A:undetectable","3lb3A-5ok4A:undetectable"],["6AP6_A_TLFA300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","5ok4","5,10-METHENYLTETRAHYDROMETHANOPTERIN HYDROGENASE","Methanothermobacter marburgensis",5,"PHE A  70;ILE A 127;VAL A  65;PHE A  66;HIS A  41","None;None;FEG A 404 ( 4.9A);None;None","1.08A","6ap6A-5ok4A:undetectable","5vlmC-5ok4A:undetectable"],["6AP6_B_TLFB300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","5ok4","5,10-METHENYLTETRAHYDROMETHANOPTERIN HYDROGENASE","Methanothermobacter marburgensis",5,"PHE A  70;ILE A 127;VAL A  65;PHE A  66;HIS A  41","None;None;FEG A 404 ( 4.9A);None;None","1.07A","6ap6B-5ok4A:undetectable","6ap6A-5ok4A:undetectable"]]