SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FED'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 LEU A  43
VAL A 243
ILE A 290
SER A 294
LEU A 541
 None
FED  A 801 (-3.8A)
FED  A 801 (-4.9A)
None
None
 1.16A 1s19A-4h7uA:
undetectable		 1s19A-4h7uA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 11 GLY A 282
ALA A  21
LEU A 242
VAL A 246
VAL A 259
 FED  A 801 (-3.5A)
None
FED  A 801 (-4.1A)
None
None
 0.97A 1ukbA-4h7uA:
undetectable		 1ukbA-4h7uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 8 GLY A 282
GLY A  24
THR A  25
ALA A  26
 FED  A 801 (-3.5A)
FED  A 801 (-3.3A)
FED  A 801 (-3.2A)
FED  A 801 (-3.5A)
 0.54A 2ej3A-4h7uA:
undetectable		 2ej3A-4h7uA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 7 TRP A 119
VAL A 514
SER A 321
THR A 557
 None
None
None
FED  A 801 (-3.7A)
 1.09A 3arrA-4h7uA:
undetectable		 3arrA-4h7uA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 GLY A  24
GLY A  22
ILE A  72
GLY A  98
GLY A  99
 FED  A 801 (-3.3A)
FED  A 801 (-3.3A)
None
None
FED  A 801 (-3.1A)
 0.98A 3axzA-4h7uA:
undetectable		 3axzA-4h7uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 9 THR A  25
VAL A  20
LEU A  34
ILE A 572
GLY A 283
 FED  A 801 (-3.2A)
None
None
None
FED  A 801 (-3.5A)
 1.23A 3cv9A-4h7uA:
undetectable		 3cv9A-4h7uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 GLY A 359
GLY A  61
SER A  64
VAL A 107
HIS A 556
 None
None
None
FED  A 801 (-3.8A)
FED  A 801 (-3.6A)
 1.11A 3dlcA-4h7uA:
2.8		 3dlcA-4h7uA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 LEU A  28
GLY A 282
GLY A  23
LEU A  97
CYH A 100
 None
FED  A 801 (-3.5A)
FED  A 801 ( 4.7A)
None
FED  A 801 (-3.2A)
 1.11A 3e23A-4h7uA:
undetectable		 3e23A-4h7uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 LEU A  28
GLY A 283
GLY A  23
LEU A  97
CYH A 100
 None
FED  A 801 (-3.5A)
FED  A 801 ( 4.7A)
None
FED  A 801 (-3.2A)
 0.99A 3e23A-4h7uA:
undetectable		 3e23A-4h7uA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 8 GLY A 283
ILE A 290
VAL A 280
VAL A 543
 FED  A 801 (-3.5A)
FED  A 801 (-4.9A)
None
None
 0.79A 3fi0G-4h7uA:
undetectable		 3fi0G-4h7uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 8 GLY A 283
ILE A 290
VAL A 280
VAL A 543
 FED  A 801 (-3.5A)
FED  A 801 (-4.9A)
None
None
 0.78A 3fi0Q-4h7uA:
undetectable		 3fi0Q-4h7uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 11 LEU A 291
ALA A 286
GLY A  22
VAL A 246
ILE A 290
 None
FED  A 801 (-3.1A)
FED  A 801 (-3.3A)
None
FED  A 801 (-4.9A)
 0.98A 3oxxD-4h7uA:
undetectable		 3oxxD-4h7uA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 SER A 223
GLY A 282
GLY A  99
GLY A  98
VAL A 544
 None
FED  A 801 (-3.5A)
FED  A 801 (-3.1A)
None
None
 1.10A 4b17A-4h7uA:
2.6		 4b17A-4h7uA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 7 GLY A  98
ALA A  47
GLU A  46
GLN A 558
 None
FED  A 801 (-3.5A)
FED  A 801 (-2.7A)
FED  A 801 (-4.3A)
 0.98A 4g0uB-4h7uA:
undetectable		 4g0uB-4h7uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 6 GLY A  98
ALA A  47
GLU A  46
GLN A 558
 None
FED  A 801 (-3.5A)
FED  A 801 (-2.7A)
FED  A 801 (-4.3A)
 0.97A 4g0uA-4h7uA:
undetectable		 4g0uA-4h7uA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 VAL A  29
ALA A  26
TYR A 562
VAL A 561
GLY A  24
 None
FED  A 801 (-3.5A)
None
FED  A 801 (-4.6A)
FED  A 801 (-3.3A)
 1.22A 4mm4B-4h7uA:
undetectable		 4mm4B-4h7uA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 GLY A  27
ALA A 281
GLY A  23
GLY A  22
THR A 244
 None
None
FED  A 801 ( 4.7A)
FED  A 801 (-3.3A)
None
 0.96A 4o3fA-4h7uA:
undetectable		 4o3fA-4h7uA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		4 / 6 PHE A 367
LEU A 428
HIS A 556
THR A 109
 None
None
FED  A 801 (-3.6A)
None
 1.33A 4paeA-4h7uA:
undetectable		 4paeA-4h7uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 12 GLY A  24
GLY A  22
ILE A  72
GLY A  98
GLY A  99
 FED  A 801 (-3.3A)
FED  A 801 (-3.3A)
None
None
FED  A 801 (-3.1A)
 1.04A 4yvgA-4h7uA:
undetectable		 4yvgA-4h7uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 9 ALA A 546
SER A 547
ALA A  26
VAL A 280
GLY A  24
 FED  A 801 (-3.3A)
None
FED  A 801 (-3.5A)
None
FED  A 801 (-3.3A)
 1.28A 6bklA-4h7uA:
undetectable
6bklB-4h7uA:
undetectable
6bklC-4h7uA:
undetectable
6bklD-4h7uA:
undetectable		 6bklA-4h7uA:
4.42
6bklB-4h7uA:
4.42
6bklC-4h7uA:
4.42
6bklD-4h7uA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4h7u PYRANOSE
DEHYDROGENASE
(Leucoagaricus
meleagris) 		5 / 9 ALA A  63
SER A  64
ALA A 360
GLY A 105
ALA A 394
 None
None
None
FED  A 801 (-3.1A)
None
 1.01A 6bklE-4h7uA:
undetectable
6bklF-4h7uA:
undetectable
6bklG-4h7uA:
undetectable
6bklH-4h7uA:
undetectable		 6bklE-4h7uA:
4.42
6bklF-4h7uA:
4.42
6bklG-4h7uA:
4.42
6bklH-4h7uA:
4.42