SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FBP'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1a5z L-LACTATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 LEU A  29
GLY A  61
ILE A  78
TYR A  79
LEU A  88
 None
None
None
FBP  A 354 (-4.0A)
None
 1.08A 1p91A-1a5zA:
2.9		 1p91A-1a5zA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 FBP  A 350 ( 2.6A)
None
MG  A 348 (-3.3A)
MG  A 347 ( 3.4A)
 1.30A 3dh0A-3rplA:
undetectable		 3dh0A-3rplA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		3 / 3 ARG A 237
ASP A  33
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.78A 4kicB-1w8sA:
undetectable		 4kicB-1w8sA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		3 / 3 SER A  92
TYR A 114
ASP A  24
 None
None
FBP  A 270 (-2.8A)
 0.85A 4rp8C-1w8sA:
undetectable		 4rp8C-1w8sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 LEU A 104
VAL A 201
ASP A 200
 None
None
FBP  A 350 (-2.8A)
 0.69A 4y8wC-3rplA:
undetectable		 4y8wC-3rplA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		5 / 11 LEU A 221
VAL A 220
PHE A 213
LEU A 247
GLY A 203
 None
None
None
None
FBP  A 270 (-3.2A)
 1.33A 4zbqA-1w8sA:
undetectable		 4zbqA-1w8sA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASP A  33
ALA A  36
GLN A 316
GLY A 296
GLU A 100
 MG  A 348 (-3.0A)
None
None
None
FBP  A 350 ( 3.1A)
 1.31A 5hfjC-3rplA:
undetectable		 5hfjC-3rplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		3 / 3 GLY A 204
GLY A 203
GLN A 216
 FBP  A 270 (-3.2A)
FBP  A 270 (-3.2A)
None
 0.47A 5imsA-1w8sA:
undetectable		 5imsA-1w8sA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I
(Thermoproteus
tenax) 		5 / 12 VAL A 234
ILE A  76
GLU A  28
PHE A  55
ALA A 229
 None
None
FBP  A 270 (-4.9A)
None
None
 1.03A 5n5dB-1w8sA:
undetectable		 5n5dB-1w8sA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 12 GLY A 207
GLY A 209
GLY A 214
VAL A 170
ILE A 161
 None
FBP  A3499 ( 4.0A)
None
None
None
 0.94A 5njvC-3d1rA:
undetectable		 5njvC-3d1rA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 LEU A 233
ILE A 208
GLY A 209
GLY A 210
VAL A 238
 None
None
FBP  A3499 ( 4.0A)
FBP  A3499 (-3.7A)
None
 0.84A 5twjD-3d1rA:
undetectable		 5twjD-3d1rA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		3 / 3 LEU A 101
VAL A 189
ASP A 188
 None
None
FBP  A3499 (-2.8A)
 0.58A 5x23A-3d1rA:
undetectable		 5x23A-3d1rA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 ALA A 234
ALA A 263
GLY A 209
GLY A 210
ALA A 211
 None
None
FBP  A3499 ( 4.0A)
FBP  A3499 (-3.7A)
None
 0.85A 6hwdK-3d1rA:
undetectable
6hwdL-3d1rA:
undetectable		 6hwdK-3d1rA:
13.08
6hwdL-3d1rA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX
(Escherichia
coli) 		5 / 11 ALA A 234
ALA A 263
GLY A 209
GLY A 210
ALA A 211
 None
None
FBP  A3499 ( 4.0A)
FBP  A3499 (-3.7A)
None
 0.85A 6hwdY-3d1rA:
undetectable
6hwdZ-3d1rA:
undetectable		 6hwdY-3d1rA:
13.08
6hwdZ-3d1rA:
14.29