SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FB6'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 1v8bA-3sl1A:
2.3		 1v8bA-3sl1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 1v8bB-3sl1A:
2.3		 1v8bB-3sl1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 1v8bD-3sl1A:
undetectable		 1v8bD-3sl1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.27A 3ce6D-3sl1A:
2.0		 3ce6D-3sl1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		3 / 3 SER A 229
GLU A 368
ASP A 365
 FB6  A 414 (-2.6A)
FB6  A 414 ( 3.9A)
None
 0.80A 3dmhA-3sl1A:
3.4		 3dmhA-3sl1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.27A 3g1uB-3sl1A:
undetectable		 3g1uB-3sl1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.32A 3g1uD-3sl1A:
2.3		 3g1uD-3sl1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		9 / 9 HIS A 218
ASP A 220
ASN A 222
SER A 229
HIS A 233
GLY A 234
ASP A 274
GLU A 277
THR A 337
 MN  A 412 ( 3.3A)
FB6  A 414 ( 2.6A)
FB6  A 414 (-4.0A)
FB6  A 414 (-2.6A)
FB6  A 414 (-3.5A)
FB6  A 414 (-3.6A)
FB6  A 414 (-2.9A)
FB6  A 414 ( 4.0A)
FB6  A 414 ( 4.2A)
 0.40A 3gn0A-3sl1A:
44.6		 3gn0A-3sl1A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		9 / 9 HIS A 218
ASP A 220
ASN A 222
SER A 229
HIS A 233
GLY A 234
ASP A 274
GLU A 277
THR A 337
 MN  A 412 ( 3.3A)
FB6  A 414 ( 2.6A)
FB6  A 414 (-4.0A)
FB6  A 414 (-2.6A)
FB6  A 414 (-3.5A)
FB6  A 414 (-3.6A)
FB6  A 414 (-2.9A)
FB6  A 414 ( 4.0A)
FB6  A 414 ( 4.2A)
 0.40A 3gn0B-3sl1A:
44.9		 3gn0B-3sl1A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 GLY A 219
THR A 236
GLU A 277
ASP A 216
ILE A 270
 None
None
FB6  A 414 ( 4.0A)
MN  A 413 (-2.6A)
None
 1.25A 3id5B-3sl1A:
3.6		 3id5B-3sl1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 GLY A 219
THR A 236
GLU A 277
ASP A 216
ILE A 270
 None
None
FB6  A 414 ( 4.0A)
MN  A 413 (-2.6A)
None
 1.25A 3id5F-3sl1A:
undetectable		 3id5F-3sl1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 3n58C-3sl1A:
3.1		 3n58C-3sl1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 3ondA-3sl1A:
2.2		 3ondA-3sl1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 3ondB-3sl1A:
3.1		 3ondB-3sl1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 7 ASP A 274
ASP A 323
ASP A 220
GLU A 277
 FB6  A 414 (-2.9A)
MN  A 412 (-2.8A)
FB6  A 414 ( 2.6A)
FB6  A 414 ( 4.0A)
 1.22A 4gkhG-3sl1A:
undetectable		 4gkhG-3sl1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 274
ASP A 323
ASP A 220
GLU A 277
 FB6  A 414 (-2.9A)
MN  A 412 (-2.8A)
FB6  A 414 ( 2.6A)
FB6  A 414 ( 4.0A)
 1.26A 4gkhJ-3sl1A:
undetectable		 4gkhJ-3sl1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		3 / 3 ASP A 216
ASP A 220
ASN A 231
 MN  A 413 (-2.6A)
FB6  A 414 ( 2.6A)
None
 0.83A 4q5mA-3sl1A:
undetectable		 4q5mA-3sl1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 LEU A  31
ASP A 365
GLU A 368
ILE A 162
 None
None
FB6  A 414 ( 3.9A)
None
 0.95A 4xi3C-3sl1A:
undetectable		 4xi3C-3sl1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 7 GLY A 194
ASP A 192
GLU A 164
SER A 227
 None
None
None
FB6  A 414 ( 4.3A)
 0.94A 4z53A-3sl1A:
2.5
4z53B-3sl1A:
2.3		 4z53A-3sl1A:
21.38
4z53B-3sl1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 5axdA-3sl1A:
2.6		 5axdA-3sl1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 5axdC-3sl1A:
2.7		 5axdC-3sl1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 ASP A 374
HIS A 233
ASP A 220
HIS A 218
ASP A 216
 None
FB6  A 414 (-3.5A)
FB6  A 414 ( 2.6A)
MN  A 412 ( 3.3A)
MN  A 413 (-2.6A)
 1.19A 5ef8B-3sl1A:
13.0		 5ef8B-3sl1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.21A 5m5kB-3sl1A:
3.1		 5m5kB-3sl1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 5m66A-3sl1A:
2.7		 5m66A-3sl1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 5m66C-3sl1A:
2.8		 5m66C-3sl1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.27A 5utuF-3sl1A:
2.1		 5utuF-3sl1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.24A 6f3nB-3sl1A:
undetectable		 6f3nB-3sl1A:
23.40