SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FAY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 SER A  94
GLY A  88
GLY A 268
TRP A  66
THR A 272
 FAY  A 600 (-2.9A)
None
FAY  A 600 (-3.5A)
FAY  A 600 (-4.0A)
None
 0.97A 3gczA-3q9tA:
2.3		 3gczA-3q9tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 PHE A 512
PRO A  84
THR A  86
ILE A  50
LEU A  59
 FAY  A 600 (-3.6A)
None
FAY  A 600 (-4.4A)
None
None
 1.15A 3iv6A-3q9tA:
2.0		 3iv6A-3q9tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 PHE A 512
PRO A  84
THR A  86
ILE A  50
LEU A  59
 FAY  A 600 (-3.6A)
None
FAY  A 600 (-4.4A)
None
None
 1.17A 3iv6C-3q9tA:
2.0		 3iv6C-3q9tA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 ASP A 545
ILE A 552
PRO A 553
LEU A 305
THR A 272
 FAY  A 600 (-4.5A)
None
None
None
None
 0.98A 3nrrA-3q9tA:
undetectable		 3nrrA-3q9tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 ASP A 545
ILE A 552
PRO A 553
LEU A 305
THR A 272
 FAY  A 600 (-4.5A)
None
None
None
None
 0.98A 3nrrB-3q9tA:
undetectable		 3nrrB-3q9tA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 9 GLY A  16
GLY A  19
SER A  96
GLY A  92
TYR A 562
 FAY  A 600 (-3.2A)
None
None
None
None
 1.32A 3ztvA-3q9tA:
undetectable		 3ztvA-3q9tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 9 GLY A  16
GLY A  19
SER A  96
GLY A  93
TYR A 562
 FAY  A 600 (-3.2A)
None
None
FAY  A 600 (-3.2A)
None
 0.89A 3ztvA-3q9tA:
undetectable		 3ztvA-3q9tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		4 / 6 GLY A  92
ALA A  39
GLU A  38
GLN A 558
 None
FAY  A 600 (-3.3A)
FAY  A 600 (-2.6A)
FAY  A 600 (-4.1A)
 1.11A 4g0uA-3q9tA:
undetectable		 4g0uA-3q9tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 VAL A  37
ALA A  39
TRP A  66
LEU A 233
VAL A  13
 None
FAY  A 600 (-3.3A)
FAY  A 600 (-4.0A)
None
None
 1.19A 4kyaB-3q9tA:
undetectable		 4kyaB-3q9tA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 VAL A  37
ALA A  39
TRP A  66
LEU A 233
VAL A  13
 None
FAY  A 600 (-3.3A)
FAY  A 600 (-4.0A)
None
None
 1.17A 4kyaD-3q9tA:
undetectable		 4kyaD-3q9tA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 VAL A  37
ALA A  39
TRP A  66
LEU A 233
VAL A  13
 None
FAY  A 600 (-3.3A)
FAY  A 600 (-4.0A)
None
None
 1.18A 4kyaF-3q9tA:
undetectable		 4kyaF-3q9tA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 VAL A  37
ALA A  39
TRP A  66
LEU A 233
VAL A  13
 None
FAY  A 600 (-3.3A)
FAY  A 600 (-4.0A)
None
None
 1.17A 4kyaH-3q9tA:
undetectable		 4kyaH-3q9tA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		4 / 8 GLU A 271
GLN A 267
VAL A 245
THR A 246
 ACT  A   1 ( 2.8A)
FAY  A 600 (-3.2A)
None
None
 1.04A 4lnwA-3q9tA:
undetectable		 4lnwA-3q9tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		4 / 6 GLU A 271
GLN A 267
VAL A 245
THR A 246
 ACT  A   1 ( 2.8A)
FAY  A 600 (-3.2A)
None
None
 1.05A 4lnxA-3q9tA:
undetectable		 4lnxA-3q9tA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 10 GLY A  93
GLY A  16
SER A 133
GLY A 211
SER A 212
 FAY  A 600 (-3.2A)
FAY  A 600 (-3.2A)
None
None
None
 1.02A 5aqfA-3q9tA:
undetectable		 5aqfA-3q9tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 10 GLY A  93
GLY A  16
SER A 133
GLY A 211
SER A 212
 FAY  A 600 (-3.2A)
FAY  A 600 (-3.2A)
None
None
None
 1.03A 5aqfC-3q9tA:
undetectable		 5aqfC-3q9tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 10 GLY A  93
GLY A  16
SER A 133
GLY A 211
SER A 212
 FAY  A 600 (-3.2A)
FAY  A 600 (-3.2A)
None
None
None
 0.99A 5aqyA-3q9tA:
undetectable		 5aqyA-3q9tA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 SER A  94
GLY A  88
GLY A 268
TRP A  66
THR A 272
 FAY  A 600 (-2.9A)
None
FAY  A 600 (-3.5A)
FAY  A 600 (-4.0A)
None
 0.89A 5ec8A-3q9tA:
2.5		 5ec8A-3q9tA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 SER A  94
GLY A  88
GLY A 268
TRP A  66
THR A 272
 FAY  A 600 (-2.9A)
None
FAY  A 600 (-3.5A)
FAY  A 600 (-4.0A)
None
 0.88A 5ekxA-3q9tA:
2.6		 5ekxA-3q9tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 12 GLY A 402
LEU A  97
GLY A 211
THR A 203
PHE A 512
 None
FAY  A 600 (-4.9A)
None
None
FAY  A 600 (-3.6A)
 1.25A 5fsaB-3q9tA:
undetectable		 5fsaB-3q9tA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS
(Aspergillus
oryzae) 		5 / 10 ARG A 556
ILE A 186
GLY A 196
GLY A 358
VAL A 103
 FAY  A 600 (-4.1A)
None
None
None
None
 1.07A 5o96C-3q9tA:
undetectable
5o96D-3q9tA:
undetectable		 5o96C-3q9tA:
17.59
5o96D-3q9tA:
17.59