SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FAH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		3 / 3 ALA A 104
VAL A 126
TRP A 255
 FAH  A 501 (-3.5A)
None
None
 0.82A 1av2C-3b12A:
undetectable
1av2D-3b12A:
undetectable		 1av2C-3b12A:
4.66
1av2D-3b12A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		4 / 7 TRP A 179
ARG A 108
TYR A 147
TYR A 212
 None
FAH  A 501 (-4.1A)
FAH  A 501 ( 4.9A)
FAH  A 501 (-4.7A)
 1.40A 1kiaC-3b12A:
undetectable		 1kiaC-3b12A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		4 / 7 TRP A 179
ARG A 108
TYR A 147
TYR A 212
 None
FAH  A 501 (-4.1A)
FAH  A 501 ( 4.9A)
FAH  A 501 (-4.7A)
 1.41A 1kiaD-3b12A:
undetectable		 1kiaD-3b12A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		3 / 3 ALA A 104
VAL A 126
TRP A 255
 FAH  A 501 (-3.5A)
None
None
 0.81A 1w5uC-3b12A:
undetectable
1w5uD-3b12A:
undetectable		 1w5uC-3b12A:
4.66
1w5uD-3b12A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 219
ASP A 218
TRP A 156
HIS A 229
 FAH  A 401 (-4.5A)
None
FAH  A 401 (-4.2A)
None
 1.17A 2ha2A-5swnA:
12.9		 2ha2A-5swnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 219
ASP A 218
TRP A 156
HIS A 229
 FAH  A 401 (-4.5A)
None
FAH  A 401 (-4.2A)
None
 1.18A 2ha2B-5swnA:
12.7		 2ha2B-5swnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		3 / 3 TRP A 255
ALA A 104
VAL A 126
 None
FAH  A 501 (-3.5A)
None
 0.77A 2izqA-3b12A:
undetectable
2izqB-3b12A:
undetectable		 2izqA-3b12A:
4.66
2izqB-3b12A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 5 HIS A 109
TYR A  68
ARG A 111
GLY A 112
 None
None
FAH  A 401 (-3.8A)
None
 1.00A 3b9mA-5swnA:
undetectable		 3b9mA-5swnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 112
ASN A 110
GLY A  39
LEU A  35
PHE A 104
 None
FAH  A 401 (-3.3A)
None
None
None
 0.93A 3ihtA-5swnA:
undetectable		 3ihtA-5swnA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		3 / 3 ALA A 104
VAL A 126
TRP A 255
 FAH  A 501 (-3.5A)
None
None
 0.74A 3l8lA-3b12A:
undetectable
3l8lB-3b12A:
undetectable		 3l8lA-3b12A:
4.66
3l8lB-3b12A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		3 / 3 ALA A 104
VAL A 126
TRP A 255
 FAH  A 501 (-3.5A)
None
None
 0.82A 3l8lC-3b12A:
undetectable
3l8lD-3b12A:
undetectable		 3l8lC-3b12A:
4.66
3l8lD-3b12A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		4 / 6 TYR A 147
TYR A 212
LEU A 153
PHE A  34
 FAH  A 501 ( 4.9A)
FAH  A 501 (-4.7A)
None
None
 1.15A 4twdI-3b12A:
undetectable
4twdJ-3b12A:
undetectable		 4twdI-3b12A:
21.65
4twdJ-3b12A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		3 / 3 VAL A 143
PHE A 136
ARG A 108
 None
None
FAH  A 501 (-4.1A)
 0.94A 4xr4B-3b12A:
3.7		 4xr4B-3b12A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		4 / 5 PHE A 272
PHE A 273
ASP A 128
HIS A 271
 None
None
None
FAH  A 501 (-4.0A)
 1.39A 6b58C-3b12A:
0.0		 6b58C-3b12A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 3b12 FLUOROACETATE
DEHALOGENASE
(Burkholderia
sp.) 		4 / 7 GLY A 207
TYR A  62
HIS A 149
GLY A  33
 None
None
FAH  A 501 (-4.2A)
None
 0.78A 6n7fA-3b12A:
undetectable		 6n7fA-3b12A:
14.23