SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FAB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 353
ASN A 358
GLY A 350
VAL A 303
 None
None
FAB  A 701 ( 3.8A)
None
 0.89A 1dbbH-3e9yA:
undetectable
1dbbL-3e9yA:
undetectable		 1dbbH-3e9yA:
17.15
1dbbL-3e9yA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 THR A 379
VAL A 378
LEU A 349
ALA A 386
 None
FAB  A 701 ( 4.7A)
None
None
 0.96A 2e1qC-3e9yA:
undetectable		 2e1qC-3e9yA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 371
ILE A 396
ASP A 414
VAL A 415
GLY A 334
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.8A)
FAB  A 701 (-4.0A)
FAB  A 701 (-3.8A)
None
 0.84A 2qe6A-3e9yA:
2.2		 2qe6A-3e9yA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 311
GLY A 307
GLY A 309
THR A 331
LEU A 349
 None
FAB  A 701 (-3.2A)
FAB  A 701 (-3.4A)
FAB  A 701 (-2.9A)
None
 1.41A 3dh0A-3e9yA:
2.7		 3dh0A-3e9yA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 VAL A 361
TYR A 305
LEU A 367
VAL A 378
GLY A 380
 None
None
None
FAB  A 701 ( 4.7A)
None
 1.21A 3pghB-3e9yA:
undetectable		 3pghB-3e9yA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 522
GLY A 162
ALA A 155
ALA A 182
ASP A 185
 None
None
None
None
FAB  A 701 ( 4.8A)
 1.03A 3sudD-3e9yA:
undetectable		 3sudD-3e9yA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 522
GLY A 162
ALA A 155
ALA A 182
ASP A 185
 None
None
None
None
FAB  A 701 ( 4.8A)
 0.94A 3sugA-3e9yA:
undetectable		 3sugA-3e9yA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A 183
TRP A 504
GLN A 489
MET A 333
 None
None
FAB  A 701 (-3.5A)
FAB  A 701 (-4.0A)
 1.47A 5h8tA-3e9yA:
undetectable		 5h8tA-3e9yA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 371
ASP A 395
ILE A 396
ASP A 397
ASP A 414
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.0A)
FAB  A 701 (-3.8A)
None
FAB  A 701 (-4.0A)
 0.57A 6bq4A-3e9yA:
3.7		 6bq4A-3e9yA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 371
ASP A 395
ILE A 396
ASP A 397
ASP A 414
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.0A)
FAB  A 701 (-3.8A)
None
FAB  A 701 (-4.0A)
 0.59A 6bq4B-3e9yA:
3.7		 6bq4B-3e9yA:
10.41