SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'FA1'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 1gu1 3-DEHYDROQUINATE
DEHYDRATASE
(Streptomyces
coelicolor) 		4 / 5 HIS A  85
SER A  84
SER A 123
VAL A 122
 FA1  A 201 (-4.0A)
FA1  A 201 ( 4.5A)
None
None
 1.49A 4a99D-1gu1A:
undetectable		 4a99D-1gu1A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1gu1 3-DEHYDROQUINATE
DEHYDRATASE
(Streptomyces
coelicolor) 		4 / 5 ALA A  81
ILE A 107
LEU A  20
ASN A  79
 FA1  A 201 (-3.7A)
FA1  A 201 (-3.8A)
GOL  A 202 (-4.3A)
FA1  A 201 (-3.0A)
 1.17A 4g19A-1gu1A:
0.7		 4g19A-1gu1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1gu1 3-DEHYDROQUINATE
DEHYDRATASE
(Streptomyces
coelicolor) 		4 / 7 GLY A  14
GLN A  55
TYR A  28
ASN A  79
 None
None
GOL  A 202 (-3.7A)
FA1  A 201 (-3.0A)
 1.05A 4ws0A-1gu1A:
3.4		 4ws0A-1gu1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1gu1 3-DEHYDROQUINATE
DEHYDRATASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  81
ASN A  79
PRO A  80
TYR A 138
LEU A  17
 FA1  A 201 (-3.7A)
FA1  A 201 (-3.0A)
None
None
GOL  A 202 (-4.6A)
 1.36A 4xqeA-1gu1A:
4.1		 4xqeA-1gu1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 1gu1 3-DEHYDROQUINATE
DEHYDRATASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  81
ASN A  79
PRO A  80
TYR A 138
LEU A  17
 FA1  A 201 (-3.7A)
FA1  A 201 (-3.0A)
None
None
GOL  A 202 (-4.6A)
 1.36A 4xqeB-1gu1A:
2.9		 4xqeB-1gu1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 1gu1 3-DEHYDROQUINATE
DEHYDRATASE
(Streptomyces
coelicolor) 		5 / 12 ALA A  81
ASN A  79
PRO A  80
TYR A 138
LEU A  17
 FA1  A 201 (-3.7A)
FA1  A 201 (-3.0A)
None
None
GOL  A 202 (-4.6A)
 1.37A 4xrgB-1gu1A:
2.8		 4xrgB-1gu1A:
18.38