SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F8E'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A  64
GLY A  65
ALA A  85
MET A 131
GLY A 135
LEU A 199
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
None
F8E  A1340 (-3.8A)
 0.99A 4qmzA-4btmA:
25.7		 4qmzA-4btmA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 6 CYH A 115
ASN A 183
GLU A 101
LYS A  87
 F8E  A1340 (-3.2A)
None
None
F8E  A1340 ( 4.0A)
 1.09A 4wcxC-4btmA:
undetectable		 4wcxC-4btmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 ILE A  64
GLY A  65
PHE A 117
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
None
 0.82A 5hieA-4btmA:
4.0		 5hieA-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 8 ILE A  64
GLY A  65
PHE A 117
ASN A 137
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
F8E  A1340 ( 4.5A)
None
 0.96A 5hieD-4btmA:
19.8		 5hieD-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 10 GLY A  65
ALA A  85
MET A 131
LEU A 133
ASN A 137
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
 0.77A 5lw1E-4btmA:
14.2		 5lw1E-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  65
ALA A  85
LEU A 133
ASN A 137
LEU A 199
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
F8E  A1340 (-3.8A)
 0.87A 5lw1H-4btmA:
14.0		 5lw1H-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  65
ALA A  85
MET A 131
LEU A 133
ASN A 137
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
 0.67A 5lw1H-4btmA:
14.0		 5lw1H-4btmA:
11.47