SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F7E'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRQ_A_STRA501_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1)	6gpl	GDP-MANNOSE 4,6 DEHYDRATASE (Homo sapiens)	5 / 11	LEU B 332 GLU B 328 VAL B 329 GLU B 210 TRP B 249	None F7E B 402 (-2.9A) None NAP B 403 ( 4.9A) None	1.23A	1mrqA-6gplB: 2.0	1mrqA-6gplB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y00_B_Y00B601_2 (BETA-1 ADRENERGIC RECEPTOR)	6gpl	GDP-MANNOSE 4,6 DEHYDRATASE (Homo sapiens)	3 / 3	VAL B 114 ASN B 208 TRP B 249	F7E B 402 (-4.1A) F7E B 402 ( 3.1A) None	1.08A	2y00B-6gplB: undetectable	2y00B-6gplB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZW4_A_SAMA302_1 (PUTATIVE O-METHYLTRANSFERASE YRRM)	6gpl	GDP-MANNOSE 4,6 DEHYDRATASE (Homo sapiens)	4 / 6	SER B 156 GLU B 328 ARG B 325 ASP B 244	F7E B 402 (-3.5A) F7E B 402 (-2.9A) F7E B 402 (-3.2A) None	1.18A	5zw4A-6gplB: 8.0	5zw4A-6gplB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A4I_B_TRPB403_0 (TRYPTOPHAN 2,3-DIOXYGENASE)	6gpl	GDP-MANNOSE 4,6 DEHYDRATASE (Homo sapiens)	4 / 7	ARG B 325 THR B 327 PRO B 326 PRO B 178	F7E B 402 (-3.2A) None None None	1.29A	6a4iB-6gplB: undetectable	6a4iB-6gplB: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BPL_B_PA1B605_1 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	6gpl	GDP-MANNOSE 4,6 DEHYDRATASE (Homo sapiens)	3 / 3	ARG B 325 ARG B 214 ARG B 247	F7E B 402 (-3.2A) F7E B 402 (-2.8A) F7E B 402 (-3.2A)	1.07A	6bplA-6gplB: undetectable 6bplB-6gplB: undetectable	6bplA-6gplB: undetectable 6bplB-6gplB: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MRQ_A_STRA501_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1","6gpl","GDP-MANNOSE 4,6 DEHYDRATASE","Homo sapiens",5,"LEU B 332;GLU B 328;VAL B 329;GLU B 210;TRP B 249","None;F7E B 402 (-2.9A);None;NAP B 403 ( 4.9A);None","1.23A","1mrqA-6gplB:2.0",null],["2Y00_B_Y00B601_2","BETA-1 ADRENERGIC RECEPTOR","6gpl","GDP-MANNOSE 4,6 DEHYDRATASE","Homo sapiens",3,"VAL B 114;ASN B 208;TRP B 249","F7E B 402 (-4.1A);F7E B 402 ( 3.1A);None","1.08A","2y00B-6gplB:undetectable","1mrqA-6gplB:undetectable"],["5ZW4_A_SAMA302_1","PUTATIVE O-METHYLTRANSFERASE YRRM","6gpl","GDP-MANNOSE 4,6 DEHYDRATASE","Homo sapiens",4,"SER B 156;GLU B 328;ARG B 325;ASP B 244","F7E B 402 (-3.5A);F7E B 402 (-2.9A);F7E B 402 (-3.2A);None","1.18A","5zw4A-6gplB:8.0","2y00B-6gplB:undetectable"],["6A4I_B_TRPB403_0","TRYPTOPHAN 2,3-DIOXYGENASE","6gpl","GDP-MANNOSE 4,6 DEHYDRATASE","Homo sapiens",4,"ARG B 325;THR B 327;PRO B 326;PRO B 178","F7E B 402 (-3.2A);None;None;None","1.29A","6a4iB-6gplB:undetectable","5zw4A-6gplB:undetectable"],["6BPL_B_PA1B605_1","LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA;LIPID A EXPORT ATP-BINDING\/PERMEASE PROTEIN MSBA","6gpl","GDP-MANNOSE 4,6 DEHYDRATASE","Homo sapiens",3,"ARG B 325;ARG B 214;ARG B 247","F7E B 402 (-3.2A);F7E B 402 (-2.8A);F7E B 402 (-3.2A)","1.07A","6bplA-6gplB:undetectable;6bplB-6gplB:undetectable","6a4iB-6gplB:undetectable"]]