SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F6R'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio
cholerae)
5 / 12 VAL A 138
GLY A 137
GLY A 142
PHE A 146
LEU A 194
None
F6R  A 301 (-3.2A)
None
F6R  A 301 ( 4.7A)
None
1.08A 1fduA-5hj5A:
undetectable
1fduA-5hj5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
4 / 8 GLY A  29
LEU A 215
VAL A 168
PHE A  86
F6R  A 304 ( 3.7A)
None
F6R  A 304 (-3.6A)
None
0.96A 1gsfC-4n6fA:
undetectable
1gsfC-4n6fA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
5 / 12 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
1.23A 1nbhA-4n6fA:
undetectable
1nbhA-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
5 / 12 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
1.23A 1nbhC-4n6fA:
undetectable
1nbhC-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
5 / 12 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
1.23A 1nbhD-4n6fA:
undetectable
1nbhD-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum)
4 / 5 ASP A   6
LEU A  31
ALA A 166
LEU A 164
F6R  A 226 (-3.0A)
None
F6R  A 226 (-3.3A)
F6R  A 226 ( 4.4A)
1.14A 1nh8A-3s1vA:
undetectable
1nh8A-3s1vA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 4 GLY A  33
SER A 190
VAL A 120
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.22A 1yajB-2bkxA:
undetectable
1yajB-2bkxA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.39A 2eimJ-2bkxA:
undetectable
2eimJ-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.41A 2eimW-2bkxA:
undetectable
2eimW-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
4 / 7 ARG A  61
ASP A 112
GLY A  29
ILE A  30
None
F6R  A 304 (-3.4A)
F6R  A 304 ( 3.7A)
None
0.86A 2fxdB-4n6fA:
undetectable
2fxdB-4n6fA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
5 / 8 ARG A 192
ASP A  67
LEU A  66
GLY A 140
TYR A  80
None
F6R  A1243 (-3.1A)
F6R  A1243 (-4.0A)
F6R  A1243 (-3.0A)
None
1.46A 2tsrB-2bkxA:
undetectable
2tsrB-2bkxA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
5 / 9 ASP A  67
LEU A  66
GLY A 140
TYR A  80
THR A 126
F6R  A1243 (-3.1A)
F6R  A1243 (-4.0A)
F6R  A1243 (-3.0A)
None
None
1.26A 2tsrD-2bkxA:
undetectable
2tsrD-2bkxA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum)
4 / 8 TYR A 128
SER A 130
ILE A  97
SER A  58
None
F6R  A 226 (-2.8A)
None
None
0.95A 2xz5B-3s1vA:
undetectable
2xz5E-3s1vA:
undetectable
2xz5B-3s1vA:
21.90
2xz5E-3s1vA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.38A 3ag2J-2bkxA:
undetectable
3ag2J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.38A 3ag4J-2bkxA:
undetectable
3ag4J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans)
4 / 8 ALA A 430
PHE A 448
THR A 455
ILE A 459
None
None
F6R  A5003 (-3.2A)
None
0.96A 3bpxA-2putA:
undetectable
3bpxB-2putA:
undetectable
3bpxA-2putA:
17.93
3bpxB-2putA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 7 GLY A  38
GLY A  37
TYR A 168
ASN A 165
F6R  A1243 (-3.7A)
F6R  A1243 (-3.5A)
None
F6R  A1243 ( 4.8A)
1.02A 4fgkB-2bkxA:
2.3
4fgkB-2bkxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus
laevis)
4 / 7 THR B 109
LEU B 514
ASN B 511
SER B 144
F6R  B 701 (-3.7A)
None
None
None
1.05A 4pfjA-3w0lB:
3.3
4pfjA-3w0lB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus
laevis)
5 / 12 GLY B 108
ILE B 145
SER B 144
ILE B 178
ALA B 114
F6R  B 701 (-3.6A)
None
None
None
None
1.00A 4qtuD-3w0lB:
undetectable
4qtuD-3w0lB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio
cholerae)
5 / 9 THR A  44
ALA A 169
VAL A 203
GLY A 137
ASP A 141
F6R  A 301 (-3.5A)
None
None
F6R  A 301 (-3.2A)
None
0.98A 4qvnK-5hj5A:
undetectable
4qvnL-5hj5A:
undetectable
4qvnK-5hj5A:
22.78
4qvnL-5hj5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio
cholerae)
5 / 9 THR A  44
ALA A 169
VAL A 203
GLY A 137
ASP A 141
F6R  A 301 (-3.5A)
None
None
F6R  A 301 (-3.2A)
None
0.98A 4qvnY-5hj5A:
undetectable
4qvnZ-5hj5A:
undetectable
4qvnY-5hj5A:
22.78
4qvnZ-5hj5A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
5 / 12 ILE A 139
GLY A 140
LEU A  66
SER A 189
LEU A 188
None
F6R  A1243 (-3.0A)
F6R  A1243 (-4.0A)
None
None
0.67A 5twjC-2bkxA:
undetectable
5twjC-2bkxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
5 / 7 GLY A 183
ILE A 139
GLY A 140
LEU A  66
ILE A 128
None
None
F6R  A1243 (-3.0A)
F6R  A1243 (-4.0A)
None
1.16A 5vkqA-2bkxA:
undetectable
5vkqB-2bkxA:
undetectable
5vkqA-2bkxA:
9.78
5vkqB-2bkxA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
5 / 8 GLY A 183
ILE A 139
GLY A 140
LEU A  66
ILE A 128
None
None
F6R  A1243 (-3.0A)
F6R  A1243 (-4.0A)
None
1.13A 5vkqB-2bkxA:
undetectable
5vkqC-2bkxA:
undetectable
5vkqB-2bkxA:
9.78
5vkqC-2bkxA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
6 / 12 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
1.37A 5vooA-4n6fA:
6.9
5vooA-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
6 / 12 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
1.37A 5vooC-4n6fA:
3.5
5vooC-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis)
6 / 12 GLU A 194
GLY A 196
VAL A  42
LEU A  38
GLY A  29
ARG A 114
F6R  A 304 (-3.6A)
F6R  A 304 (-3.5A)
None
None
F6R  A 304 ( 3.7A)
F6R  A 304 (-2.8A)
1.35A 5vopA-4n6fA:
7.2
5vopA-4n6fA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.41A 5wauJ-2bkxA:
undetectable
5wauJ-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis)
4 / 5 TYR A 116
MET A 182
THR A 181
LEU A  66
None
None
None
F6R  A1243 (-4.0A)
1.40A 5z86J-2bkxA:
undetectable
5z86J-2bkxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5i51 TRANSKETOLASE
(Scheffersomyces
stipitis)
3 / 3 HIS A  66
HIS A 100
ARG A  91
TPP  A 701 ( 3.5A)
F6R  A 702 (-3.9A)
F6R  A 702 ( 4.8A)
0.97A 6b58A-5i51A:
undetectable
6b58A-5i51A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus
laevis)
5 / 12 GLU B 347
PRO B 350
ASN B 510
GLU B 153
ASP B 154
F6R  B 701 (-3.2A)
None
None
F6R  B 701 (-3.8A)
None
1.31A 6ekuA-3w0lB:
undetectable
6ekuA-3w0lB:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus
laevis)
4 / 5 GLY B 108
THR B 109
SER B 257
SER B 258
F6R  B 701 (-3.6A)
F6R  B 701 (-3.7A)
F6R  B 701 ( 4.7A)
F6R  B 701 (-3.4A)
1.03A 6jmjA-3w0lB:
undetectable
6jmjA-3w0lB:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus
laevis)
4 / 6 GLY B 108
THR B 109
SER B 257
SER B 258
F6R  B 701 (-3.6A)
F6R  B 701 (-3.7A)
F6R  B 701 ( 4.7A)
F6R  B 701 (-3.4A)
1.01A 6jogA-3w0lB:
undetectable
6jogA-3w0lB:
14.13