SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F6R'
DrReposER ID / Desc. | Hit PDBID |
Hit Macromolecule |
Res. Matches |
Interface | HETATM | RMSD | Dali Z-score |
Seq. Identity (%) |
View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1FDU_A_ESTA351_1 (17-BETA-HYDROXYSTEROID DEHYDROGENASE) |
5hj5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Vibriocholerae) | 5 / 12 | VAL A 138GLY A 137GLY A 142PHE A 146LEU A 194 | NoneF6R A 301 (-3.2A)NoneF6R A 301 ( 4.7A)None | 1.08A | 1fduA-5hj5A:undetectable | 1fduA-5hj5A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1GSF_C_EAAC223_1 (GLUTATHIONETRANSFERASE A1-1) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 4 / 8 | GLY A 29LEU A 215VAL A 168PHE A 86 | F6R A 304 ( 3.7A)NoneF6R A 304 (-3.6A)None | 0.96A | 1gsfC-4n6fA:undetectable | 1gsfC-4n6fA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_A_SAMA293_0 (GLYCINEN-METHYLTRANSFERASE) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 5 / 12 | ILE A 180GLY A 195VAL A 193ALA A 169SER A 170 | NoneF6R A 304 (-3.5A)NoneF6R A 304 (-4.7A)None | 1.23A | 1nbhA-4n6fA:undetectable | 1nbhA-4n6fA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_C_SAMC2293_0 (GLYCINEN-METHYLTRANSFERASE) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 5 / 12 | ILE A 180GLY A 195VAL A 193ALA A 169SER A 170 | NoneF6R A 304 (-3.5A)NoneF6R A 304 (-4.7A)None | 1.23A | 1nbhC-4n6fA:undetectable | 1nbhC-4n6fA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NBH_D_SAMD3293_0 (GLYCINEN-METHYLTRANSFERASE) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 5 / 12 | ILE A 180GLY A 195VAL A 193ALA A 169SER A 170 | NoneF6R A 304 (-3.5A)NoneF6R A 304 (-4.7A)None | 1.23A | 1nbhD-4n6fA:undetectable | 1nbhD-4n6fA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1NH8_A_HISA289_0 (ATPPHOSPHORIBOSYLTRANSFERASE) |
3s1v | PROBABLETRANSALDOLASE (Thermoplasmaacidophilum) | 4 / 5 | ASP A 6LEU A 31ALA A 166LEU A 164 | F6R A 226 (-3.0A)NoneF6R A 226 (-3.3A)F6R A 226 ( 4.4A) | 1.14A | 1nh8A-3s1vA:undetectable | 1nh8A-3s1vA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1YAJ_B_BEZB12_0 (CES1 PROTEIN) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 4 | GLY A 33SER A 190VAL A 120LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.22A | 1yajB-2bkxA:undetectable | 1yajB-2bkxA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EIM_J_CHDJ60_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIIA-HEART) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 5 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.39A | 2eimJ-2bkxA:undetectable | 2eimJ-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2EIM_W_CHDW1060_0 (CYTOCHROME C OXIDASEPOLYPEPTIDEVIIA-HEART) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 5 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.41A | 2eimW-2bkxA:undetectable | 2eimW-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2FXD_A_DR7A102_2 (POL PROTEIN) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 4 / 7 | ARG A 61ASP A 112GLY A 29ILE A 30 | NoneF6R A 304 (-3.4A)F6R A 304 ( 3.7A)None | 0.86A | 2fxdB-4n6fA:undetectable | 2fxdB-4n6fA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 5 / 8 | ARG A 192ASP A 67LEU A 66GLY A 140TYR A 80 | NoneF6R A1243 (-3.1A)F6R A1243 (-4.0A)F6R A1243 (-3.0A)None | 1.46A | 2tsrB-2bkxA:undetectable | 2tsrB-2bkxA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2TSR_D_D16D609_1 (THYMIDYLATE SYNTHASE) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 5 / 9 | ASP A 67LEU A 66GLY A 140TYR A 80THR A 126 | F6R A1243 (-3.1A)F6R A1243 (-4.0A)F6R A1243 (-3.0A)NoneNone | 1.26A | 2tsrD-2bkxA:undetectable | 2tsrD-2bkxA:24.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2XZ5_B_ACHB1211_0 (SOLUBLEACETYLCHOLINERECEPTOR) |
3s1v | PROBABLETRANSALDOLASE (Thermoplasmaacidophilum) | 4 / 8 | TYR A 128SER A 130ILE A 97SER A 58 | NoneF6R A 226 (-2.8A)NoneNone | 0.95A | 2xz5B-3s1vA:undetectable2xz5E-3s1vA:undetectable | 2xz5B-3s1vA:21.902xz5E-3s1vA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AG2_J_CHDJ60_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 5 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.38A | 3ag2J-2bkxA:undetectable | 3ag2J-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AG4_J_CHDJ60_0 (CYTOCHROME C OXIDASEPOLYPEPTIDE 7A1) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 5 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.38A | 3ag4J-2bkxA:undetectable | 3ag4J-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3BPX_A_SALA257_1 (TRANSCRIPTIONALREGULATOR) |
2put | ISOMERASE DOMAIN OFGLUTAMINE-FRUCTOSE-6-PHOSPHATETRANSAMINASE(ISOMERIZING) (Candidaalbicans) | 4 / 8 | ALA A 430PHE A 448THR A 455ILE A 459 | NoneNoneF6R A5003 (-3.2A)None | 0.96A | 3bpxA-2putA:undetectable3bpxB-2putA:undetectable | 3bpxA-2putA:17.933bpxB-2putA:17.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4FGK_A_0TXA302_1 (RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE[QUINONE]) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 7 | GLY A 38GLY A 37TYR A 168ASN A 165 | F6R A1243 (-3.7A)F6R A1243 (-3.5A)NoneF6R A1243 ( 4.8A) | 1.02A | 4fgkB-2bkxA:2.3 | 4fgkB-2bkxA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4PFJ_A_ADNA502_2 (ADENOSYLHOMOCYSTEINASE) |
3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopuslaevis) | 4 / 7 | THR B 109LEU B 514ASN B 511SER B 144 | F6R B 701 (-3.7A)NoneNoneNone | 1.05A | 4pfjA-3w0lB:3.3 | 4pfjA-3w0lB:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QTU_D_SAMD301_0 (PUTATIVEMETHYLTRANSFERASEBUD23) |
3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopuslaevis) | 5 / 12 | GLY B 108ILE B 145SER B 144ILE B 178ALA B 114 | F6R B 701 (-3.6A)NoneNoneNoneNone | 1.00A | 4qtuD-3w0lB:undetectable | 4qtuD-3w0lB:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QVN_K_BO2K301_1 (PROTEASOME SUBUNITBETA TYPE-5PROTEASOME SUBUNITBETA TYPE-6) |
5hj5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Vibriocholerae) | 5 / 9 | THR A 44ALA A 169VAL A 203GLY A 137ASP A 141 | F6R A 301 (-3.5A)NoneNoneF6R A 301 (-3.2A)None | 0.98A | 4qvnK-5hj5A:undetectable4qvnL-5hj5A:undetectable | 4qvnK-5hj5A:22.784qvnL-5hj5A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4QVN_Y_BO2Y301_1 (PROTEASOME SUBUNITBETA TYPE-5PROTEASOME SUBUNITBETA TYPE-6) |
5hj5 | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Vibriocholerae) | 5 / 9 | THR A 44ALA A 169VAL A 203GLY A 137ASP A 141 | F6R A 301 (-3.5A)NoneNoneF6R A 301 (-3.2A)None | 0.98A | 4qvnY-5hj5A:undetectable4qvnZ-5hj5A:undetectable | 4qvnY-5hj5A:22.784qvnZ-5hj5A:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5TWJ_C_SAMC201_0 (RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE H) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 5 / 12 | ILE A 139GLY A 140LEU A 66SER A 189LEU A 188 | NoneF6R A1243 (-3.0A)F6R A1243 (-4.0A)NoneNone | 0.67A | 5twjC-2bkxA:undetectable | 5twjC-2bkxA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VKQ_A_PCFA1807_0 (NO MECHANORECEPTORPOTENTIAL C ISOFORML) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 5 / 7 | GLY A 183ILE A 139GLY A 140LEU A 66ILE A 128 | NoneNoneF6R A1243 (-3.0A)F6R A1243 (-4.0A)None | 1.16A | 5vkqA-2bkxA:undetectable5vkqB-2bkxA:undetectable | 5vkqA-2bkxA:9.785vkqB-2bkxA:9.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VKQ_B_PCFB1804_0 (NO MECHANORECEPTORPOTENTIAL C ISOFORML) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 5 / 8 | GLY A 183ILE A 139GLY A 140LEU A 66ILE A 128 | NoneNoneF6R A1243 (-3.0A)F6R A1243 (-4.0A)None | 1.13A | 5vkqB-2bkxA:undetectable5vkqC-2bkxA:undetectable | 5vkqB-2bkxA:9.785vkqC-2bkxA:9.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VOO_A_C2FA3001_0 (5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 6 / 12 | GLU A 194GLY A 196VAL A 42LEU A 38GLY A 29ARG A 114 | F6R A 304 (-3.6A)F6R A 304 (-3.5A)NoneNoneF6R A 304 ( 3.7A)F6R A 304 (-2.8A) | 1.37A | 5vooA-4n6fA:6.9 | 5vooA-4n6fA:26.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VOO_C_C2FC702_0 (5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 6 / 12 | GLU A 194GLY A 196VAL A 42LEU A 38GLY A 29ARG A 114 | F6R A 304 (-3.6A)F6R A 304 (-3.5A)NoneNoneF6R A 304 ( 3.7A)F6R A 304 (-2.8A) | 1.37A | 5vooC-4n6fA:3.5 | 5vooC-4n6fA:26.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5VOP_A_C2FA3001_0 (5-METHYLTETRAHYDROFOLATE HOMOCYSTEINES-METHYLTRANSFERASE) |
4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) | 6 / 12 | GLU A 194GLY A 196VAL A 42LEU A 38GLY A 29ARG A 114 | F6R A 304 (-3.6A)F6R A 304 (-3.5A)NoneNoneF6R A 304 ( 3.7A)F6R A 304 (-2.8A) | 1.35A | 5vopA-4n6fA:7.2 | 5vopA-4n6fA:26.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5WAU_J_CHDJ101_1 (CYTOCHROME C OXIDASESUBUNIT 7A1,MITOCHONDRIAL) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 5 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.41A | 5wauJ-2bkxA:undetectable | 5wauJ-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5Z86_J_CHDJ101_0 (CYTOCHROME C OXIDASESUBUNIT 7A1,MITOCHONDRIAL) |
2bkx | GLUCOSAMINE-6-PHOSPHATE DEAMINASE (Bacillussubtilis) | 4 / 5 | TYR A 116MET A 182THR A 181LEU A 66 | NoneNoneNoneF6R A1243 (-4.0A) | 1.40A | 5z86J-2bkxA:undetectable | 5z86J-2bkxA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6B58_A_ACTA609_0 (FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT) |
5i51 | TRANSKETOLASE (Scheffersomycesstipitis) | 3 / 3 | HIS A 66HIS A 100ARG A 91 | TPP A 701 ( 3.5A)F6R A 702 (-3.9A)F6R A 702 ( 4.8A) | 0.97A | 6b58A-5i51A:undetectable | 6b58A-5i51A:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6EKU_A_ZMRA901_1 (SIALIDASE) |
3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopuslaevis) | 5 / 12 | GLU B 347PRO B 350ASN B 510GLU B 153ASP B 154 | F6R B 701 (-3.2A)NoneNoneF6R B 701 (-3.8A)None | 1.31A | 6ekuA-3w0lB:undetectable | 6ekuA-3w0lB:22.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6JMJ_A_ASCA201_0 (PHOSPHOPANTETHEINEADENYLYLTRANSFERASE) |
3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopuslaevis) | 4 / 5 | GLY B 108THR B 109SER B 257SER B 258 | F6R B 701 (-3.6A)F6R B 701 (-3.7A)F6R B 701 ( 4.7A)F6R B 701 (-3.4A) | 1.03A | 6jmjA-3w0lB:undetectable | 6jmjA-3w0lB:14.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6JOG_A_ASCA201_0 (PHOSPHOPANTETHEINEADENYLYLTRANSFERASE) |
3w0l | GLUCOKINASEREGULATORY PROTEIN (Xenopuslaevis) | 4 / 6 | GLY B 108THR B 109SER B 257SER B 258 | F6R B 701 (-3.6A)F6R B 701 (-3.7A)F6R B 701 ( 4.7A)F6R B 701 (-3.4A) | 1.01A | 6jogA-3w0lB:undetectable | 6jogA-3w0lB:14.13 |