SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F6P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 2r66 GLYCOSYL
TRANSFERASE, GROUP 1
(Halothermothrix
orenii) 		5 / 11 TYR A 128
GLU A 184
TYR A 211
HIS A 208
GLU A 159
 F6P  A 501 (-4.6A)
None
None
None
None
 1.45A 1fdtA-2r66A:
6.0		 1fdtA-2r66A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 356
GLY A 492
THR B 377
GLY A 215
 F6P  A 988 (-2.8A)
None
None
F6P  A 988 ( 4.8A)
 0.87A 1jr1B-3o8oA:
undetectable		 1jr1B-3o8oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 254
ASP A 263
LYS A 284
 F6P  A1001 ( 2.6A)
None
None
 1.17A 1lqtB-3pt1A:
2.1		 1lqtB-3pt1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ofu FBP PROTEIN
(Leishmania
major) 		4 / 8 VAL A 180
ASP A 121
HIS A 257
LEU A 261
 None
F6P  A 402 (-2.6A)
None
None
 1.23A 1pk2A-5ofuA:
undetectable		 1pk2A-5ofuA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 548
VAL A 397
ILE A 355
ILE A 375
 None
None
F6P  A 988 (-4.9A)
None
 0.80A 1uwhA-3o8oA:
undetectable		 1uwhA-3o8oA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 6 ILE A 314
ALA A 305
THR A 152
ALA A 131
 None
None
F6P  A 401 (-3.5A)
None
 0.83A 1w0gA-3bxhA:
undetectable		 1w0gA-3bxhA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2r66 GLYCOSYL
TRANSFERASE, GROUP 1
(Halothermothrix
orenii) 		5 / 12 PRO A  15
THR A 149
GLY A 129
GLY A 131
SER A 152
 None
None
None
None
F6P  A 501 (-2.9A)
 1.06A 1wg8A-2r66A:
4.1		 1wg8A-2r66A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 345
SER B 346
GLY B 359
VAL B 297
ILE B 218
 None
F6P  B 980 ( 4.4A)
None
None
None
 1.12A 2b25B-3o8oB:
undetectable		 2b25B-3o8oB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2r66 GLYCOSYL
TRANSFERASE, GROUP 1
(Halothermothrix
orenii) 		5 / 12 TYR A  75
ILE A  55
GLY A  33
LEU A  99
TYR A 128
 None
None
F6P  A 501 (-3.5A)
None
F6P  A 501 (-4.6A)
 1.41A 2nyrB-2r66A:
3.7		 2nyrB-2r66A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 SER A 370
GLY A 367
HIS A 488
ASP B 473
 None
None
F6P  A 988 (-4.2A)
None
 1.26A 2oxtC-3o8oA:
undetectable		 2oxtC-3o8oA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 TYR A 333
TYR A 408
TYR A 356
ILE A 323
 F6P  A1448 (-4.8A)
None
None
None
 1.19A 2ph9A-4d4lA:
undetectable
2ph9B-4d4lA:
undetectable		 2ph9A-4d4lA:
18.67
2ph9B-4d4lA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2
(Homo
sapiens) 		4 / 7 TYR A 337
TYR A 412
TYR A 360
ILE A 327
 F6P  A 604 (-4.6A)
None
None
F6P  A 604 ( 4.4A)
 1.13A 2ph9A-5htkA:
undetectable
2ph9B-5htkA:
undetectable		 2ph9A-5htkA:
19.04
2ph9B-5htkA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 8 LEU B 397
ARG B 392
VAL B 344
GLY B 345
 None
F6P  B 980 (-3.8A)
None
None
 0.97A 2po5B-3o8oB:
4.9		 2po5B-3o8oB:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae) 		4 / 7 ARG B 383
ILE A 355
ASP A 309
GLY A 308
 F6P  A 988 (-2.3A)
F6P  A 988 (-4.9A)
None
None
 0.77A 2tsrA-3o8oB:
undetectable		 2tsrA-3o8oB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 4lc9 GLUCOKINASE
REGULATORY PROTEIN
(Rattus
norvegicus) 		6 / 12 GLY A 181
GLY A 177
GLY A 106
LEU A 137
GLU A 153
VAL A 175
 F6P  A 701 (-3.6A)
None
None
None
None
None
 1.40A 2wa2B-4lc9A:
undetectable		 2wa2B-4lc9A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		5 / 12 LEU A 391
LEU A 395
SER A 430
GLN A 388
HIS A 441
 None
None
None
F6P  A1448 ( 4.2A)
None
 1.26A 3m7rA-4d4lA:
undetectable		 3m7rA-4d4lA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		5 / 12 LEU A 391
LEU A 395
SER A 430
GLN A 388
HIS A 441
 None
None
None
F6P  A1447 ( 4.0A)
None
 1.27A 3m7rA-5ajzA:
undetectable		 3m7rA-5ajzA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 6 GLU A 360
ILE A 323
GLU A 322
ASN A 321
 None
None
F6P  A1448 (-3.7A)
None
 0.99A 3pgyA-4d4lA:
2.3
3pgyB-4d4lA:
2.1		 3pgyA-4d4lA:
20.00
3pgyB-4d4lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 6 GLU A 360
ILE A 323
GLU A 322
ASN A 321
 None
None
F6P  A1447 (-3.5A)
None
 0.99A 3pgyA-5ajzA:
2.4
3pgyB-5ajzA:
2.2		 3pgyA-5ajzA:
21.41
3pgyB-5ajzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2
(Homo
sapiens) 		4 / 6 GLU A 364
ILE A 327
GLU A 326
ASN A 325
 None
F6P  A 604 ( 4.4A)
F6P  A 604 (-3.1A)
None
 1.01A 3pgyA-5htkA:
undetectable
3pgyB-5htkA:
undetectable		 3pgyA-5htkA:
22.20
3pgyB-5htkA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4lc9 GLUCOKINASE
REGULATORY PROTEIN
(Rattus
norvegicus) 		4 / 8 GLY A 181
ALA A 184
SER A 179
GLU A 153
 F6P  A 701 (-3.6A)
F6P  A 701 ( 4.2A)
F6P  A 701 (-2.9A)
None
 0.83A 3u9hA-4lc9A:
undetectable		 3u9hA-4lc9A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4lc9 GLUCOKINASE
REGULATORY PROTEIN
(Rattus
norvegicus) 		4 / 8 GLY A 181
ALA A 184
SER A 179
GLU A 153
 F6P  A 701 (-3.6A)
F6P  A 701 ( 4.2A)
F6P  A 701 (-2.9A)
None
 0.77A 3u9hB-4lc9A:
undetectable		 3u9hB-4lc9A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.44A 3w9tA-6ayvA:
undetectable		 3w9tA-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.45A 3w9tC-6ayvA:
undetectable		 3w9tC-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.45A 3w9tD-6ayvA:
undetectable		 3w9tD-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2
(Mycobacterium
tuberculosis) 		4 / 5 ASP A  79
GLU A  51
GLY A  50
GLU A 208
 MG  A 402 (-2.7A)
None
None
F6P  A 401 ( 3.5A)
 1.45A 3w9tG-6ayvA:
undetectable		 3w9tG-6ayvA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 8 LYS A  63
ILE A 118
ASN A 117
GLY A 114
 None
None
None
F6P  A 603 ( 3.7A)
 0.69A 3wxoA-2owzA:
undetectable		 3wxoA-2owzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 8 LEU A 178
ARG A 251
TYR A 273
GLU A 269
 SCN  A   1 (-4.4A)
F6P  A 401 (-3.7A)
None
F6P  A 401 (-2.9A)
 1.33A 3zmdA-3bxhA:
undetectable
3zmdB-3bxhA:
undetectable		 3zmdA-3bxhA:
18.53
3zmdB-3bxhA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4lc9 GLUCOKINASE
REGULATORY PROTEIN
(Rattus
norvegicus) 		4 / 8 GLY A 181
ALA A 184
SER A 179
GLU A 153
 F6P  A 701 (-3.6A)
F6P  A 701 ( 4.2A)
F6P  A 701 (-2.9A)
None
 0.79A 4bjcA-4lc9A:
undetectable		 4bjcA-4lc9A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 GLU B 414
PHE B 561
ASP B 350
ASP B 348
GLY B 448
 None
None
None
F6P  B 980 (-3.0A)
None
 1.41A 4djfB-3o8oB:
undetectable		 4djfB-3o8oB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 5 ARG A 249
VAL A 244
LEU A 243
SER A 242
 None
None
F6P  A 603 (-4.3A)
F6P  A 603 ( 4.7A)
 1.26A 4e1gA-2owzA:
undetectable		 4e1gA-2owzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4lc9 GLUCOKINASE
REGULATORY PROTEIN
(Rattus
norvegicus) 		4 / 8 THR A 266
ILE A 178
VAL A 187
GLY A 181
 None
None
None
F6P  A 701 (-3.6A)
 0.94A 4eq4B-4lc9A:
3.3		 4eq4B-4lc9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3pt1 UPF0364 PROTEIN
YMR027W
(Saccharomyces
cerevisiae) 		5 / 12 ARG A  23
GLU A 110
GLY A  16
TYR A 114
VAL A 290
 F6P  A1001 (-3.2A)
F6P  A1001 (-2.7A)
None
None
None
 1.45A 4ffwB-3pt1A:
undetectable		 4ffwB-3pt1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA
(Saccharomyces
cerevisiae) 		5 / 12 HIS B 481
ARG B 484
LEU B 397
PRO B 209
ILE B 347
 F6P  B 980 (-4.1A)
F6P  B 980 (-3.4A)
None
None
None
 1.33A 4kmuC-3o8oB:
undetectable		 4kmuC-3o8oB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		4 / 7 GLU A 180
THR A 151
GLY A 150
THR A 152
 F6P  A 401 (-3.3A)
F6P  A 401 (-2.9A)
F6P  A 401 (-3.5A)
F6P  A 401 (-3.5A)
 0.90A 4qwpB-3bxhA:
undetectable		 4qwpB-3bxhA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2
(Homo
sapiens) 		5 / 12 SER A 272
ALA A 329
THR A 336
THR A 444
ARG A 256
 None
F6P  A 604 ( 4.9A)
None
F6P  A 604 ( 3.3A)
NEP  A 257 ( 3.7A)
 1.26A 4z7fC-5htkA:
undetectable		 4z7fC-5htkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ofu FBP PROTEIN
(Leishmania
major) 		5 / 12 GLY A 162
ILE A 249
GLY A 122
LEU A 279
PHE A 322
 None
CL  A 403 (-4.0A)
F6P  A 402 (-3.6A)
None
None
 1.10A 4zdyA-5ofuA:
undetectable		 4zdyA-5ofuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 6 GLY A 125
THR A 126
SER A 242
VAL A 244
 None
None
F6P  A 603 ( 4.7A)
None
 1.09A 5ewuB-2owzA:
undetectable		 5ewuB-2owzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 12 SER A 309
GLN A 119
ALA A 305
GLY A 306
THR A 152
 None
None
None
None
F6P  A 401 (-3.5A)
 1.29A 5l5zH-3bxhA:
undetectable
5l5zI-3bxhA:
undetectable		 5l5zH-3bxhA:
21.09
5l5zI-3bxhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 12 SER A 309
GLN A 119
ALA A 305
GLY A 306
THR A 152
 None
None
None
None
F6P  A 401 (-3.5A)
 1.29A 5l5zV-3bxhA:
undetectable
5l5zW-3bxhA:
undetectable		 5l5zV-3bxhA:
21.09
5l5zW-3bxhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR
(Bacillus
subtilis) 		5 / 9 ALA A 313
ALA A 305
GLY A 242
ALA A 303
GLY A 240
 None
None
F6P  A 401 (-3.5A)
None
F6P  A 401 ( 4.1A)
 1.10A 6bklE-3bxhA:
undetectable
6bklF-3bxhA:
undetectable
6bklG-3bxhA:
undetectable
6bklH-3bxhA:
undetectable		 6bklE-3bxhA:
7.06
6bklF-3bxhA:
7.06
6bklG-3bxhA:
7.06
6bklH-3bxhA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 352
GLY A 308
ASP A 309
ASP A 356
 None
None
None
F6P  A 988 (-2.8A)
 1.16A 6cjkC-3o8oA:
undetectable		 6cjkC-3o8oA:
14.43