SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F5D'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		3 / 3 THR A  15
PRO A  13
THR A  17
 F5D  A 301 (-4.0A)
None
None
 0.72A 209dC-6ck0A:
undetectable		 209dC-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		4 / 7 TRP A  50
GLU A  51
LYS A 110
ASN A 130
 F5D  A 301 (-3.8A)
F5D  A 301 (-4.7A)
F5D  A 301 (-2.5A)
F5D  A 301 (-3.0A)
 1.00A 2ejgA-6ck0A:
20.3		 2ejgA-6ck0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		4 / 7 TRP A  50
GLU A  51
LYS A 110
ASN A 130
 F5D  A 301 (-3.8A)
F5D  A 301 (-4.7A)
F5D  A 301 (-2.5A)
F5D  A 301 (-3.0A)
 1.05A 2ejgB-6ck0A:
18.8		 2ejgB-6ck0A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		5 / 11 ALA A  36
GLY A 128
ILE A  34
SER A  14
SER A  60
 None
F5D  A 301 (-3.5A)
None
F5D  A 301 (-2.7A)
F5D  A 301 ( 3.7A)
 1.19A 3gyqB-6ck0A:
undetectable		 3gyqB-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		5 / 12 ILE A 148
LEU A 139
GLY A 128
ILE A 127
ASN A 117
 None
None
F5D  A 301 (-3.5A)
None
None
 0.95A 4o1eA-6ck0A:
undetectable		 4o1eA-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		5 / 12 ILE A 148
LEU A 139
GLY A 128
ILE A 127
ASN A 117
 None
None
F5D  A 301 (-3.5A)
None
None
 0.97A 4o1eB-6ck0A:
undetectable		 4o1eB-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		5 / 11 GLY A 200
ASP A 199
ALA A  76
PRO A 101
ILE A 202
 None
None
None
F5D  A 301 ( 4.8A)
None
 1.19A 5yk2A-6ck0A:
undetectable		 5yk2A-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE
(Helicobacter
pylori) 		4 / 6 THR A  17
PRO A  13
GLN A  39
ILE A  43
 None
None
F5D  A 301 (-3.0A)
F5D  A 301 (-4.0A)
 1.49A 6ef6A-6ck0A:
1.2		 6ef6A-6ck0A:
undetectable