SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_A_DCFA353_1 (ADENOSINE DEAMINASE)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	5 / 12	HIS A 216 HIS A 248 PHE A 160 ALA A 123 ASP A 220	None F50 A 301 (-4.0A) None None None	1.19A	1a4lA-5h3hA: undetectable	1a4lA-5h3hA: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A4L_C_DCFC1353_1 (ADENOSINE DEAMINASE)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	5 / 12	HIS A 216 HIS A 248 PHE A 160 ALA A 123 ASP A 220	None F50 A 301 (-4.0A) None None None	1.22A	1a4lC-5h3hA: undetectable	1a4lC-5h3hA: 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACK_A_EDRA999_1 (ACETYLCHOLINESTERASE)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	4 / 7	GLY A 29 SER A 96 PHE A 160 HIS A 248	F50 A 301 (-3.4A) F50 A 301 (-2.4A) None F50 A 301 (-4.0A)	1.15A	2ackA-5h3hA: 2.1	2ackA-5h3hA: 20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FQY_A_ADNA400_1 (MEMBRANE LIPOPROTEIN TMPC)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	5 / 12	ASP A 253 GLY A 247 ASP A 220 PHE A 164 GLY A 161	None None None F50 A 301 (-4.7A) None	1.11A	2fqyA-5h3hA: 3.2	2fqyA-5h3hA: 22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_D_SUED1201_1 (NS3 PROTEASE, NS4A PROTEIN)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	5 / 12	HIS A 248 ASP A 220 GLY A 29 SER A 96 ALA A 120	F50 A 301 (-4.0A) None F50 A 301 (-3.4A) F50 A 301 (-2.4A) None	1.28A	3sueD-5h3hA: undetectable	3sueD-5h3hA: 23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_A_SUEA1201_1 (NS3 PROTEASE, NS4A PROTEIN)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	5 / 12	HIS A 248 GLY A 249 LEU A 119 ALA A 123 ALA A 124	F50 A 301 (-4.0A) None None None None	1.05A	3sufA-5h3hA: undetectable	3sufA-5h3hA: 23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_A_SHHA404_1 (HISTONE DEACETYLASE 8)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	5 / 12	HIS A 216 PHE A 251 ASP A 220 HIS A 248 GLY A 247	None None None F50 A 301 (-4.0A) None	1.30A	4qa2A-5h3hA: 2.2	4qa2A-5h3hA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A5Z_C_WJZC304_0 (BETA-LACTAMASE NDM-1)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	4 / 7	HIS A 248 CYH A 223 GLY A 247 HIS A 216	F50 A 301 (-4.0A) F50 A 301 ( 4.9A) None None	1.27A	5a5zC-5h3hA: undetectable	5a5zC-5h3hA: 22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YOD_B_BEZB201_0 (NS3 PROTEASE)	5h3h	ABHYDROLASE DOMAIN-CONTAINING PROTEIN (Exiguobacterium antarcticum)	4 / 5	HIS A 248 ALA A 123 SER A 96 GLY A 29	F50 A 301 (-4.0A) None F50 A 301 (-2.4A) F50 A 301 (-3.4A)	1.27A	5yodB-5h3hA: undetectable	5yodB-5h3hA: 23.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A4L_A_DCFA353_1","ADENOSINE DEAMINASE","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",5,"HIS A 216;HIS A 248;PHE A 160;ALA A 123;ASP A 220","None;F50 A 301 (-4.0A);None;None;None","1.19A","1a4lA-5h3hA:undetectable",null],["1A4L_C_DCFC1353_1","ADENOSINE DEAMINASE","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",5,"HIS A 216;HIS A 248;PHE A 160;ALA A 123;ASP A 220","None;F50 A 301 (-4.0A);None;None;None","1.22A","1a4lC-5h3hA:undetectable","1a4lA-5h3hA:22.43"],["2ACK_A_EDRA999_1","ACETYLCHOLINESTERASE","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",4,"GLY A  29;SER A  96;PHE A 160;HIS A 248","F50 A 301 (-3.4A);F50 A 301 (-2.4A);None;F50 A 301 (-4.0A)","1.15A","2ackA-5h3hA:2.1","1a4lC-5h3hA:22.43"],["2FQY_A_ADNA400_1","MEMBRANE LIPOPROTEIN TMPC","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",5,"ASP A 253;GLY A 247;ASP A 220;PHE A 164;GLY A 161","None;None;None;F50 A 301 (-4.7A);None","1.11A","2fqyA-5h3hA:3.2","2ackA-5h3hA:20.34"],["3SUE_D_SUED1201_1","NS3 PROTEASE, NS4A PROTEIN","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",5,"HIS A 248;ASP A 220;GLY A  29;SER A  96;ALA A 120","F50 A 301 (-4.0A);None;F50 A 301 (-3.4A);F50 A 301 (-2.4A);None","1.28A","3sueD-5h3hA:undetectable","2fqyA-5h3hA:22.55"],["3SUF_A_SUEA1201_1","NS3 PROTEASE, NS4A PROTEIN","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",5,"HIS A 248;GLY A 249;LEU A 119;ALA A 123;ALA A 124","F50 A 301 (-4.0A);None;None;None;None","1.05A","3sufA-5h3hA:undetectable","3sueD-5h3hA:23.33"],["4QA2_A_SHHA404_1","HISTONE DEACETYLASE 8","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",5,"HIS A 216;PHE A 251;ASP A 220;HIS A 248;GLY A 247","None;None;None;F50 A 301 (-4.0A);None","1.30A","4qa2A-5h3hA:2.2","3sufA-5h3hA:23.33"],["5A5Z_C_WJZC304_0","BETA-LACTAMASE NDM-1","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",4,"HIS A 248;CYH A 223;GLY A 247;HIS A 216","F50 A 301 (-4.0A);F50 A 301 ( 4.9A);None;None","1.27A","5a5zC-5h3hA:undetectable","4qa2A-5h3hA:20.25"],["5YOD_B_BEZB201_0","NS3 PROTEASE","5h3h","ABHYDROLASE DOMAIN-CONTAINING PROTEIN","Exiguobacterium antarcticum",4,"HIS A 248;ALA A 123;SER A  96;GLY A  29","F50 A 301 (-4.0A);None;F50 A 301 (-2.4A);F50 A 301 (-3.4A)","1.27A","5yodB-5h3hA:undetectable","5a5zC-5h3hA:22.68"]]