SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F4P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 GLY A  60
SER A 132
MET A 133
LEU A 158
HIS A 279
 F4P  A 314 ( 3.7A)
F4P  A 314 (-1.2A)
None
F4P  A 314 (-4.8A)
F4P  A 314 (-4.3A)
 0.84A 1a8uA-3jweA:
25.3		 1a8uA-3jweA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		6 / 12 GLN A 245
GLY A 130
VAL A 159
LEU A 158
GLY A 135
GLY A 134
 None
None
None
F4P  A 314 (-4.8A)
None
None
 1.46A 1uakA-3jweA:
2.2		 1uakA-3jweA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		6 / 12 SER A 156
GLN A 245
GLY A 130
VAL A 159
LEU A 158
GLY A 135
 None
None
None
None
F4P  A 314 (-4.8A)
None
 1.50A 1uakA-3jweA:
2.2		 1uakA-3jweA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 9 GLY A  60
ALA A  61
SER A 132
LEU A 215
HIS A 279
 F4P  A 314 ( 3.7A)
F4P  A 314 (-3.6A)
F4P  A 314 (-1.2A)
F4P  A 314 ( 4.1A)
F4P  A 314 (-4.3A)
 1.37A 1y7iA-3jweA:
18.6		 1y7iA-3jweA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 219
ALA A 226
LEU A 223
GLY A 220
 None
None
F4P  A 314 ( 4.3A)
None
 0.99A 4xk8a-3jweA:
undetectable		 4xk8a-3jweA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  75
ILE A 296
ALA A 138
ILE A 137
GLY A  60
 None
None
None
None
F4P  A 314 ( 3.7A)
 1.03A 5veuB-3jweA:
undetectable		 5veuB-3jweA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 260
ASP A 249
ILE A 139
SER A 132
GLY A 135
 None
None
None
F4P  A 314 (-1.2A)
None
 1.44A 6dlzA-3jweA:
2.5
6dlzD-3jweA:
3.7		 6dlzA-3jweA:
15.00
6dlzD-3jweA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 139
SER A 132
GLY A 135
LEU A 260
ASP A 249
 None
F4P  A 314 (-1.2A)
None
None
None
 1.43A 6dlzB-3jweA:
3.7
6dlzC-3jweA:
2.5		 6dlzB-3jweA:
15.00
6dlzC-3jweA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 260
ASP A 249
ILE A 139
SER A 132
GLY A 135
 None
None
None
F4P  A 314 (-1.2A)
None
 1.44A 6dm1A-3jweA:
2.5
6dm1D-3jweA:
3.5		 6dm1A-3jweA:
15.00
6dm1D-3jweA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3jwe MGLL PROTEIN
(Homo
sapiens) 		5 / 10 ILE A 139
SER A 132
GLY A 135
LEU A 260
ASP A 249
 None
F4P  A 314 (-1.2A)
None
None
None
 1.44A 6dm1B-3jweA:
3.9
6dm1C-3jweA:
2.4		 6dm1B-3jweA:
15.00
6dm1C-3jweA:
15.00