SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F43'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T46_A_STIA3_2 (HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	4 / 7	VAL A1160 VAL A1149 TYR A1176 CYH A1175	F43  A2570 (-3.8A) None None None	1.12A	1t46A-1e6yA: undetectable	1t46A-1e6yA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AI8_B_HNQB255_1 (CATHEPSIN B)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	4 / 6	GLN A 233 GLY A 146 CYH A 164 TRP A 229	F43  A 604 (-4.0A) None None None	1.25A	3ai8B-5n28A: undetectable	3ai8B-5n28A: 17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT (Methanopyrus kandleri)	3 / 3	ASN A 140 HIS A 141 VAL A 148	None None F43  A1553 (-3.6A)	0.85A	3elzB-1e6vA: 0.0	3elzB-1e6vA: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	1e6y	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanosarcina barkeri)	3 / 3	ASN A1151 HIS A1152 VAL A1159	None None F43  A2570 (-3.7A)	0.90A	3elzB-1e6yA: undetectable	3elzB-1e6yA: 12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	1mro	METHYL-COENZYME M REDUCTASE (Methanothermobac ter marburgensis)	3 / 3	ASN A 137 HIS A 138 VAL A 145	None None F43  A 700 (-3.5A)	0.88A	3elzB-1mroA: 0.0	3elzB-1mroA: 11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	ASN A 140 HIS A 141 VAL A 148	None None F43  A 603 (-3.5A)	0.84A	3elzB-5a8rA: undetectable	3elzB-5a8rA: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	5n28	METHYL-COENZYME M REDUCTASE SUBUNIT ALPHA (Methanotorris formicicus)	3 / 3	ASN A 140 HIS A 141 VAL A 148	None None F43  A 604 (-3.5A)	0.85A	3elzB-5n28A: undetectable	3elzB-5n28A: 13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVV_D_URFD254_1 (URIDINE PHOSPHORYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	GLY A 145 GLN A 233 MET A 236 VAL A 156	None F43  A 603 (-3.5A) F43  A 603 (-3.8A) None	1.14A	3kvvD-5a8rA: undetectable	3kvvD-5a8rA: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1V_F_URFF1301_1 (URIDINE PHOSPHORYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	GLY A 145 GLN A 233 MET A 236 VAL A 156	None F43  A 603 (-3.5A) F43  A 603 (-3.8A) None	1.11A	4e1vF-5a8rA: undetectable	4e1vF-5a8rA: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_A_CELA602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT (Methanopyrus kandleri)	5 / 12	ALA A 246 VAL A 148 GLY A 146 ALA A 142 LEU A 143	F43  A1553 (-3.6A) F43  A1553 (-3.6A) None None None	1.06A	5jw1A-1e6vA: 0.0	5jw1A-1e6vA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_B_CELB602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	1e6v	METHYL-COENZYME M REDUCTASE I ALPHA SUBUNIT (Methanopyrus kandleri)	5 / 12	ALA A 246 VAL A 148 GLY A 146 ALA A 142 LEU A 143	F43  A1553 (-3.6A) F43  A1553 (-3.6A) None None None	1.03A	5jw1B-1e6vA: 0.0	5jw1B-1e6vA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_B_CELB602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ALA A 246 VAL A 148 GLY A 146 ALA A 142 LEU A 143	F43  A 603 (-3.3A) F43  A 603 (-3.5A) None None None	1.10A	5jw1B-5a8rA: undetectable	5jw1B-5a8rA: 20.23