SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F42'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 4 ILE A 190
MET A 162
VAL A  62
GLY A 167
 None
F42  A 328 (-4.7A)
F42  A 328 (-4.4A)
None
 1.08A 1e06B-1z69A:
undetectable		 1e06B-1z69A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 10 GLY A  61
GLN A 302
TYR A 209
TYR A 154
THR A  34
 None
None
F42  A 328 ( 4.0A)
None
F42  A 328 (-4.1A)
 1.22A 1kvlA-1z69A:
undetectable		 1kvlA-1z69A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 426
ALA A 344
LEU A 300
SER A 400
ILE A 424
 None
None
None
F42  A 501 (-4.9A)
None
 0.98A 1rb3B-4xoqA:
undetectable		 1rb3B-4xoqA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3r5z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Nocardia
farcinica) 		3 / 3 TRP A  80
VAL A  79
PRO A  78
 F42  A 201 (-4.4A)
F42  A 201 (-3.7A)
F42  A 201 (-4.4A)
 1.00A 1rg1A-3r5zA:
undetectable		 1rg1A-3r5zA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3r5z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Nocardia
farcinica) 		3 / 3 TRP A  80
VAL A  79
PRO A  78
 F42  A 201 (-4.4A)
F42  A 201 (-3.7A)
F42  A 201 (-4.4A)
 1.00A 1rh0A-3r5zA:
undetectable		 1rh0A-3r5zA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		5 / 12 HIS A  36
LEU A  46
VAL A  48
PRO A   9
ILE A  16
 F42  A 328 (-3.8A)
None
None
None
None
 1.09A 1zq9A-1z69A:
undetectable		 1zq9A-1z69A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 VAL A 104
GLY A 105
GLY A 107
THR A 129
ALA A 132
 None
F42  A 351 ( 4.0A)
F42  A 351 (-3.2A)
None
None
 0.72A 2egvB-1rhcA:
3.7		 2egvB-1rhcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 PRO A  77
SER A 135
VAL A  74
GLY A 104
 None
None
F42  A 338 (-4.3A)
None
 1.13A 2qd3A-3b4yA:
undetectable		 2qd3A-3b4yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 4 GLY A 107
GLU A 108
ASP A  38
TYR A  80
 F42  A 351 (-3.2A)
ACN  A 352 ( 2.9A)
None
None
 1.27A 2yvlC-1rhcA:
1.3		 2yvlC-1rhcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 108
PRO A  77
LEU A 132
 F42  A 338 (-3.7A)
None
None
 0.60A 3hcpB-3b4yA:
undetectable		 3hcpB-3b4yA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.05A 4ac9C-1rhcA:
2.0		 4ac9C-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.06A 4acaC-1rhcA:
2.6		 4acaC-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 THR A  74
ILE A  73
GLU A 108
PHE A   8
 None
F42  A 351 (-4.2A)
ACN  A 352 ( 2.9A)
None
 1.08A 4acbC-1rhcA:
2.3		 4acbC-1rhcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 3r5z PUTATIVE
UNCHARACTERIZED
PROTEIN
(Nocardia
farcinica) 		4 / 4 ASN A  83
ALA A  46
GLY A  45
THR A  48
 F42  A 201 (-3.3A)
F42  A 201 (-3.7A)
F42  A 201 (-3.6A)
F42  A 201 (-2.8A)
 1.09A 4bboC-3r5zA:
undetectable		 4bboC-3r5zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		3 / 3 ASN A 176
LEU A 295
PHE A 279
 F42  A 328 (-3.9A)
None
None
 0.71A 4dajB-1z69A:
undetectable		 4dajB-1z69A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 177
ARG A 283
MET A 208
PHE A 192
 F42  A 338 (-3.4A)
FLC  A 337 (-2.8A)
None
None
 0.99A 4j4vC-3b4yA:
undetectable		 4j4vC-3b4yA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 3b4y PROBABLE
F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE FGD1
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 181
ALA A 185
PHE A 192
TYR A 203
 F42  A 338 (-4.3A)
None
None
None
 0.92A 4lb2A-3b4yA:
1.2		 4lb2A-3b4yA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 8 GLY A  95
THR A  67
TYR A  66
ASN A  64
 F42  A 328 (-3.0A)
None
None
None
 1.26A 4m5mA-1z69A:
undetectable		 4m5mA-1z69A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 422
ILE A 398
GLY A 378
PHE A 297
ILE A 424
 None
F42  A 501 (-4.5A)
None
None
None
 1.11A 4qoiA-4xoqA:
undetectable
4qoiB-4xoqA:
undetectable		 4qoiA-4xoqA:
22.55
4qoiB-4xoqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 ALA A 194
HIS A  39
GLU A  12
PHE A 255
GLU A 108
 None
ACN  A 352 ( 4.0A)
ACN  A 352 ( 4.4A)
F42  A 351 (-4.9A)
ACN  A 352 ( 2.9A)
 1.27A 4r7lA-1rhcA:
undetectable		 4r7lA-1rhcA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 7 GLY A 105
GLY A 107
THR A 129
ALA A 132
 F42  A 351 ( 4.0A)
F42  A 351 (-3.2A)
None
None
 0.76A 5o96C-1rhcA:
3.7		 5o96C-1rhcA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE
(Methanosarcina
barkeri) 		4 / 7 GLY A  93
GLY A  95
THR A 114
ALA A 117
 F42  A 328 ( 4.2A)
F42  A 328 (-3.0A)
None
None
 0.74A 5o96C-1z69A:
5.3		 5o96C-1z69A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3r5y PUTATIVE
UNCHARACTERIZED
PROTEIN
(Nocardia
farcinica) 		3 / 3 TYR A   9
ARG A  54
THR A  56
 None
F42  A 147 (-3.6A)
F42  A 147 (-4.0A)
 1.01A 5z84J-3r5yA:
undetectable		 5z84J-3r5yA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 9 VAL A  36
GLY A 105
VAL A 104
GLY A 107
PRO A  76
 None
F42  A 351 ( 4.0A)
None
F42  A 351 (-3.2A)
None
 1.29A 5zniA-1rhcA:
undetectable		 5zniA-1rhcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4xoq COENZYME
F420:L-GLUTAMATE
LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 388
GLY A 394
SER A 400
LEU A 310
ILE A 340
 None
None
F42  A 501 (-4.9A)
None
None
 1.15A 6bxmA-4xoqA:
undetectable		 6bxmA-4xoqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		5 / 12 GLN A 126
GLY A 179
VAL A 203
GLY A 105
SER A 173
 F42  A 351 (-3.6A)
F42  A 351 (-3.7A)
None
F42  A 351 ( 4.0A)
F42  A 351 (-2.5A)
 0.98A 6c2mB-1rhcA:
undetectable		 6c2mB-1rhcA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0B-1rhcA:
0.7		 6ew0B-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0D-1rhcA:
0.8		 6ew0D-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0H-1rhcA:
0.9		 6ew0H-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Methanoculleus
thermophilus) 		4 / 5 LEU A 139
THR A 154
PRO A  76
ARG A  79
 None
None
None
F42  A 351 ( 4.9A)
 1.21A 6ew0I-1rhcA:
0.6		 6ew0I-1rhcA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3r5y PUTATIVE
UNCHARACTERIZED
PROTEIN
(Nocardia
farcinica) 		3 / 3 ARG A  38
PHE A  35
GLY A  37
 None
F42  A 147 ( 4.7A)
None
 0.73A 6fgdA-3r5yA:
undetectable		 6fgdA-3r5yA:
17.89