SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F3V'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.19A 1h7xA-6ci9A:
5.4		 1h7xA-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.21A 1h7xB-6ci9A:
5.8		 1h7xB-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.20A 1h7xC-6ci9A:
4.4		 1h7xC-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ILE A  94
ASN A 115
SER A 160
THR A 145
 None
None
None
F3V  A 302 (-3.9A)
 1.20A 1h7xD-6ci9A:
5.8		 1h7xD-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 157
THR A 141
ALA A 162
SER A 160
GLY A 188
 NAP  A 301 ( 4.3A)
NAP  A 301 (-3.9A)
CL  A 303 ( 4.1A)
None
F3V  A 302 ( 4.8A)
 1.31A 1nbiD-6ci9A:
6.4		 1nbiD-6ci9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ILE A  19
THR A 192
VAL A 140
PHE A  95
 NAP  A 301 (-3.8A)
NAP  A 301 (-2.9A)
None
F3V  A 302 (-3.8A)
 0.81A 4iarA-6ci9A:
undetectable		 4iarA-6ci9A:
12.36