SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F2P'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 248
ASP A  53
GLY A  58
VAL A 236
ILE A 240
 None
None
None
F2P  A 501 (-3.8A)
None
 0.89A 3em3A-2qjgA:
undetectable		 3em3A-2qjgA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A 248
ASP A  53
GLY A  58
VAL A 236
ILE A 240
 None
None
None
F2P  A 501 (-3.8A)
None
 0.96A 3oxvA-2qjgA:
undetectable		 3oxvA-2qjgA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  39
ILE A  47
ARG A 238
HIS A  65
LEU A  64
 None
None
F2P  A 501 (-3.9A)
None
None
 1.04A 4iv0A-2qjgA:
undetectable		 4iv0A-2qjgA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  39
ILE A  47
ARG A 238
HIS A  65
LEU A  64
 None
None
F2P  A 501 (-3.9A)
None
None
 1.03A 4mwzA-2qjgA:
undetectable		 4mwzA-2qjgA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  39
ILE A  47
ARG A 238
HIS A  65
LEU A  64
 None
None
F2P  A 501 (-3.9A)
None
None
 1.03A 4mwzB-2qjgA:
undetectable		 4mwzB-2qjgA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A  37
GLY A  35
ILE A  29
ALA A 235
GLY A 237
 F2P  A 501 (-3.2A)
None
None
None
F2P  A 501 (-3.6A)
 1.09A 4r29D-2qjgA:
undetectable		 4r29D-2qjgA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 9 HIS A  65
GLY A  89
GLY A  88
ASP A  33
HIS A  85
 None
None
None
F2P  A 501 (-3.5A)
None
 1.20A 5f8yA-2qjgA:
0.0		 5f8yA-2qjgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 8 HIS A  65
GLY A  89
GLY A  88
ASP A  33
HIS A  85
 None
None
None
F2P  A 501 (-3.5A)
None
 1.24A 5f8yA-2qjgA:
undetectable		 5f8yA-2qjgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 9 HIS A  65
GLY A  89
GLY A  88
ASP A  33
HIS A  85
 None
None
None
F2P  A 501 (-3.5A)
None
 1.23A 5f8yA-2qjgA:
undetectable		 5f8yA-2qjgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 9 HIS A  65
GLY A  89
GLY A  88
ASP A  33
HIS A  85
 None
None
None
F2P  A 501 (-3.5A)
None
 1.20A 5f8yB-2qjgA:
undetectable		 5f8yB-2qjgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2qjg PUTATIVE ALDOLASE
MJ0400
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  83
THR A  27
VAL A 206
VAL A 183
MET A 151
 None
None
None
None
F2P  A 501 (-3.3A)
 1.43A 5jkwA-2qjgA:
undetectable		 5jkwA-2qjgA:
20.55