SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F1X'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2C8A_C_NCAC1252_0 (MONO-ADP-RIBOSYLTRAN SFERASE C3)	3o75	FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR (Pseudomonas putida)	4 / 6	ARG A 149 SER A 125 ARG A 188 GLU A 106	F1X A 1 (-3.5A) None None None	1.36A	2c8aC-3o75A: undetectable	2c8aC-3o75A: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SNF_A_ACTA110_0 (PROTEIN P-30)	3o75	FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR (Pseudomonas putida)	4 / 5	ILE A 185 THR A 245 THR A 246 SER A 247	None None None F1X A 1 (-3.3A)	0.95A	3snfA-3o75A: undetectable	3snfA-3o75A: 15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JLC_A_1YNA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3o75	FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR (Pseudomonas putida)	4 / 5	GLY A 210 THR A 209 GLY A 274 LEU A 184	None None F1X A 1 (-3.1A) None	0.84A	5jlcA-3o75A: 1.1	5jlcA-3o75A: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_B_FFOB403_0 (THYMIDYLATE SYNTHASE)	3o75	FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR (Pseudomonas putida)	5 / 10	PHE A 220 ASN A 276 LEU A 278 ASP A 256 GLY A 253	F1X A 1 (-3.2A) None None None None	1.36A	6r2eB-3o75A: undetectable	6r2eB-3o75A: 21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6R2E_D_FFOD403_0 (THYMIDYLATE SYNTHASE)	3o75	FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR (Pseudomonas putida)	5 / 10	PHE A 220 ASN A 276 LEU A 278 ASP A 256 GLY A 253	F1X A 1 (-3.2A) None None None None	1.39A	6r2eD-3o75A: undetectable	6r2eD-3o75A: 21.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2C8A_C_NCAC1252_0","MONO-ADP-RIBOSYLTRANSFERASE C3","3o75","FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR","Pseudomonas putida",4,"ARG A 149;SER A 125;ARG A 188;GLU A 106","F1X A   1 (-3.5A);None;None;None","1.36A","2c8aC-3o75A:undetectable",null],["3SNF_A_ACTA110_0","PROTEIN P-30","3o75","FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR","Pseudomonas putida",4,"ILE A 185;THR A 245;THR A 246;SER A 247","None;None;None;F1X A   1 (-3.3A)","0.95A","3snfA-3o75A:undetectable","2c8aC-3o75A:20.83"],["5JLC_A_1YNA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","3o75","FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR","Pseudomonas putida",4,"GLY A 210;THR A 209;GLY A 274;LEU A 184","None;None;F1X A   1 (-3.1A);None","0.84A","5jlcA-3o75A:1.1","3snfA-3o75A:15.58"],["6R2E_B_FFOB403_0","THYMIDYLATE SYNTHASE","3o75","FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR","Pseudomonas putida",5,"PHE A 220;ASN A 276;LEU A 278;ASP A 256;GLY A 253","F1X A   1 (-3.2A);None;None;None;None","1.36A","6r2eB-3o75A:undetectable","5jlcA-3o75A:18.70"],["6R2E_D_FFOD403_0","THYMIDYLATE SYNTHASE","3o75","FRUCTOSE TRANSPORT SYSTEM REPRESSOR FRUR","Pseudomonas putida",5,"PHE A 220;ASN A 276;LEU A 278;ASP A 256;GLY A 253","F1X A   1 (-3.2A);None;None;None;None","1.39A","6r2eD-3o75A:undetectable","6r2eB-3o75A:21.70"]]