SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'F10'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU X  70
GLY X  71
VAL X  78
ALA X  91
ASN X 191
LEU X 193
THR X 206
ASP X 207
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.4A)
F10  X 401 (-3.8A)
F10  X 401 (-3.4A)
 0.92A 1fmoE-2p3gX:
20.4		 1fmoE-2p3gX:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU X  70
GLY X  71
VAL X  78
ALA X  91
VAL X 118
ASN X 191
THR X 206
ASP X 207
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
None
None
F10  X 401 (-3.8A)
F10  X 401 (-3.4A)
 0.78A 1fmoE-2p3gX:
20.4		 1fmoE-2p3gX:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		5 / 12 ILE F 585
GLY F 568
VAL F 566
ALA F 605
GLY F 487
 None
None
None
FMN  F1002 ( 4.8A)
None
 0.92A 1kiaA-1bvyF:
undetectable		 1kiaA-1bvyF:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		5 / 12 ILE F 585
GLY F 568
VAL F 566
ALA F 605
GLY F 487
 None
None
None
FMN  F1002 ( 4.8A)
None
 0.90A 1kiaB-1bvyF:
undetectable		 1kiaB-1bvyF:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		5 / 12 ILE F 585
GLY F 568
VAL F 566
ALA F 605
GLY F 487
 None
None
None
FMN  F1002 ( 4.8A)
None
 0.91A 1kiaC-1bvyF:
undetectable		 1kiaC-1bvyF:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		5 / 12 ILE F 585
GLY F 568
VAL F 566
ALA F 605
GLY F 487
 None
None
None
FMN  F1002 ( 4.8A)
None
 0.93A 1nbhB-1bvyF:
undetectable		 1nbhB-1bvyF:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 8 VAL F 581
GLY F 491
THR F 492
ALA F 493
 None
FMN  F1002 (-3.9A)
FMN  F1002 (-3.7A)
FMN  F1002 (-3.4A)
 0.81A 2a1hA-1bvyF:
undetectable
2a1hB-1bvyF:
undetectable		 2a1hA-1bvyF:
19.40
2a1hB-1bvyF:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY X  71
VAL X  78
ALA X  91
ASP X 186
LYS X 188
ASN X 191
ASP X 207
 F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
None
None
None
F10  X 401 (-3.4A)
 0.81A 2fumA-2p3gX:
21.1		 2fumA-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU X  70
GLY X  71
VAL X  78
ALA X  91
ASP X 186
LYS X 188
ASN X 191
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
None
None
None
 0.79A 2fumA-2p3gX:
21.1		 2fumA-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 GLY X  71
VAL X  78
ALA X  91
MET X 138
LYS X 188
ASN X 191
ASP X 207
 F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
None
F10  X 401 (-3.4A)
 0.79A 2fumB-2p3gX:
21.1		 2fumB-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU X  70
GLY X  71
VAL X  78
ALA X  91
MET X 138
LYS X 188
ASN X 191
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
None
 0.78A 2fumB-2p3gX:
21.1		 2fumB-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU X  70
GLY X  71
VAL X  78
ALA X  91
MET X 138
ASN X 191
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
 0.75A 2fumC-2p3gX:
19.9		 2fumC-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		8 / 12 LEU X  70
GLY X  71
GLY X  73
VAL X  78
ALA X  91
MET X 138
LYS X 188
ASN X 191
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
F10  X 401 ( 4.1A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
None
None
 1.07A 2fumD-2p3gX:
20.0		 2fumD-2p3gX:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 6 LEU X  70
LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
None
 0.98A 2hyyA-2p3gX:
17.5		 2hyyA-2p3gX:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU X  70
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 0.72A 2hyyB-2p3gX:
17.6		 2hyyB-2p3gX:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 12 GLY X  73
GLY X  71
LEU X 203
GLU X 145
ASP X 207
 F10  X 401 ( 4.1A)
F10  X 401 ( 4.3A)
None
None
F10  X 401 (-3.4A)
 0.88A 2oxtA-2p3gX:
undetectable		 2oxtA-2p3gX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 LEU X  70
ALA X  91
MET X 138
ASP X 207
 F10  X 401 (-3.9A)
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 (-3.4A)
 0.58A 2yfxA-2p3gX:
19.0		 2yfxA-2p3gX:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 10 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.74A 3cs9A-2p3gX:
17.7		 3cs9A-2p3gX:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.74A 3cs9B-2p3gX:
18.2		 3cs9B-2p3gX:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU X  70
VAL X  78
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
None
 0.78A 3cs9C-2p3gX:
17.7		 3cs9C-2p3gX:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 LEU X  70
LYS X  93
ILE X 136
ARG X 185
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 1.04A 3ik3B-2p3gX:
17.5		 3ik3B-2p3gX:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU X  70
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 0.77A 3k5vA-2p3gX:
17.6		 3k5vA-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU X  70
LYS X  93
VAL X 118
ILE X 136
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
 0.78A 3k5vB-2p3gX:
17.5		 3k5vB-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-4.3A)
None
None
None
 1.06A 3ms9A-2p3gX:
17.6		 3ms9A-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-4.3A)
None
None
None
 1.12A 3ms9B-2p3gX:
17.3		 3ms9B-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-4.3A)
None
None
None
 1.07A 3mssA-2p3gX:
17.7		 3mssA-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LYS X  93
VAL X 118
ILE X 136
ARG X 185
 F10  X 401 (-4.3A)
None
None
None
 1.08A 3mssC-2p3gX:
17.7		 3mssC-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 VAL X  78
LYS X  93
VAL X 118
ILE X 136
 None
F10  X 401 (-4.3A)
None
None
 0.70A 3mssD-2p3gX:
17.6		 3mssD-2p3gX:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU X  70
LYS X  93
ILE X 136
ARG X 185
LEU X 193
 F10  X 401 (-3.9A)
F10  X 401 (-4.3A)
None
None
F10  X 401 ( 4.4A)
 1.28A 3oxzA-2p3gX:
17.9		 3oxzA-2p3gX:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 7 ASN F 543
ALA F 544
PRO F 541
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 1.09A 3twpA-1bvyF:
undetectable		 3twpA-1bvyF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 7 ASN F 543
ALA F 544
PRO F 541
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 1.10A 3twpB-1bvyF:
undetectable		 3twpB-1bvyF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 7 ASN F 543
ALA F 544
PRO F 541
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 1.12A 3twpC-1bvyF:
undetectable		 3twpC-1bvyF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 5 ASN F 543
ALA F 544
PRO F 541
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 1.09A 3twpD-1bvyF:
1.5		 3twpD-1bvyF:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 8 ASN F 543
PHE F 547
VAL F 548
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 0.94A 4eyzA-1bvyF:
undetectable		 4eyzA-1bvyF:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1bvy PROTEIN (CYTOCHROME
P450 BM-3)
(Bacillus
megaterium) 		4 / 8 ASN F 543
PHE F 547
VAL F 548
ALA F 493
 None
None
None
FMN  F1002 (-3.4A)
 0.95A 4eyzB-1bvyF:
undetectable		 4eyzB-1bvyF:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 11 VAL X  78
ALA X  91
LYS X  93
GLU X 190
LEU X 193
ASP X 207
 None
F10  X 401 (-3.4A)
F10  X 401 (-4.3A)
None
F10  X 401 ( 4.4A)
F10  X 401 (-3.4A)
 1.09A 4iaaA-2p3gX:
20.6		 4iaaA-2p3gX:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 VAL X  78
ALA X  91
LEU X  95
MET X 138
 None
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.0A)
 0.76A 4l9iA-2p3gX:
6.6		 4l9iA-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 7 VAL X  78
ALA X  91
MET X 138
LEU X 193
 None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.72A 4l9iA-2p3gX:
6.6		 4l9iA-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 GLY X  73
VAL X  78
ALA X  91
LYS X  93
MET X 138
 F10  X 401 ( 4.1A)
None
F10  X 401 (-3.4A)
F10  X 401 (-4.3A)
F10  X 401 ( 4.0A)
 1.03A 4l9iB-2p3gX:
18.7		 4l9iB-2p3gX:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 GLY X  73
VAL X  78
ALA X  91
MET X 138
LEU X 193
 F10  X 401 ( 4.1A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.96A 4l9iB-2p3gX:
18.7		 4l9iB-2p3gX:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 6 LEU X  70
GLY X  71
VAL X  78
ALA X  91
LEU X 193
 F10  X 401 (-3.9A)
F10  X 401 ( 4.3A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.4A)
 0.97A 4o0wA-2p3gX:
20.8		 4o0wA-2p3gX:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 7 GLY X  71
ALA X  91
ASN X 191
LEU X 193
ASP X 207
 F10  X 401 ( 4.3A)
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.4A)
F10  X 401 (-3.4A)
 1.28A 4ogrE-2p3gX:
19.4		 4ogrE-2p3gX:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 8 LEU X  70
VAL X  78
LYS X  93
HIS X 184
LEU X 193
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
F10  X 401 ( 4.4A)
 1.16A 4qrcA-2p3gX:
12.3		 4qrcA-2p3gX:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU X  70
VAL X  78
LYS X  93
ILE X 117
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
 0.56A 4tyjA-2p3gX:
17.8		 4tyjA-2p3gX:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 8 LEU X  70
ALA X  91
MET X 138
LEU X 193
 F10  X 401 (-3.9A)
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.67A 4wboB-2p3gX:
18.5		 4wboB-2p3gX:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 6 LEU X  70
ALA X  91
MET X 138
LEU X 193
 F10  X 401 (-3.9A)
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.73A 4wboC-2p3gX:
18.6		 4wboC-2p3gX:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 LEU X  70
VAL X  78
ALA X  91
MET X 138
LEU X 193
THR X 206
 F10  X 401 (-3.9A)
None
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
F10  X 401 (-3.8A)
 0.82A 5n3hA-2p3gX:
20.0		 5n3hA-2p3gX:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		6 / 10 LEU X  70
VAL X  78
ALA X  91
VAL X 118
MET X 138
THR X 206
 F10  X 401 (-3.9A)
None
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.0A)
F10  X 401 (-3.8A)
 0.59A 5n3hA-2p3gX:
20.0		 5n3hA-2p3gX:
30.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_2
(WEE1-LIKE PROTEIN
KINASE)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		4 / 4 VAL X  78
LYS X  93
VAL X 118
ASN X 191
 None
F10  X 401 (-4.3A)
None
None
 0.75A 5vc3A-2p3gX:
20.1		 5vc3A-2p3gX:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2
(Homo
sapiens) 		5 / 9 LEU X  70
ALA X  91
VAL X 118
MET X 138
THR X 206
 F10  X 401 (-3.9A)
F10  X 401 (-3.4A)
None
F10  X 401 ( 4.0A)
F10  X 401 (-3.8A)
 0.94A 5w5vA-2p3gX:
4.2		 5w5vA-2p3gX:
16.99