SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EZS'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_F_SNLF6001_2 (MINERALOCORTICOID RECEPTOR)	6cfp	UBIQUITIN-LIKE PROTEIN SMT3,POLYMERASE ACIDIC PROTEIN (Influenza A virus; Saccharomyces cerevisiae)	4 / 5	LEU A 345 LEU A 342 LEU A 543 MET A 311	EZS A 801 (-3.6A) EZS A 801 (-4.2A) None None	0.91A	2oaxF-6cfpA: undetectable	2oaxF-6cfpA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO7_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	6cfp	UBIQUITIN-LIKE PROTEIN SMT3,POLYMERASE ACIDIC PROTEIN (Saccharomyces cerevisiae; Influenza A virus)	5 / 9	LEU A 500 LEU A 342 VAL A 545 GLY A 546 MET A 548	None EZS A 801 (-4.2A) None None None	1.33A	2po7B-6cfpA: undetectable	2po7B-6cfpA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_1 (CDL2.3B)	6cfp	UBIQUITIN-LIKE PROTEIN SMT3,POLYMERASE ACIDIC PROTEIN (Influenza A virus; Saccharomyces cerevisiae)	5 / 12	LEU A 543 LEU A 482 LEU A 345 PHE A 525 LEU A 500	None None EZS A 801 (-3.6A) None None	1.23A	5iepA-6cfpA: undetectable	5iepA-6cfpA: 19.85

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OAX_F_SNLF6001_2","MINERALOCORTICOID RECEPTOR","6cfp","UBIQUITIN-LIKE PROTEIN SMT3,POLYMERASE ACIDIC PROTEIN","Influenza A virus;Saccharomyces cerevisiae",4,"LEU A 345;LEU A 342;LEU A 543;MET A 311","EZS A 801 (-3.6A);EZS A 801 (-4.2A);None;None","0.91A","2oaxF-6cfpA:undetectable",null],["2PO7_B_CHDB502_0","FERROCHELATASE, MITOCHONDRIAL","6cfp","UBIQUITIN-LIKE PROTEIN SMT3,POLYMERASE ACIDIC PROTEIN","Saccharomyces cerevisiae;Influenza A virus",5,"LEU A 500;LEU A 342;VAL A 545;GLY A 546;MET A 548","None;EZS A 801 (-4.2A);None;None;None","1.33A","2po7B-6cfpA:undetectable","2oaxF-6cfpA:14.29"],["5IEP_A_VDYA201_1","CDL2.3B","6cfp","UBIQUITIN-LIKE PROTEIN SMT3,POLYMERASE ACIDIC PROTEIN","Influenza A virus;Saccharomyces cerevisiae",5,"LEU A 543;LEU A 482;LEU A 345;PHE A 525;LEU A 500","None;None;EZS A 801 (-3.6A);None;None","1.23A","5iepA-6cfpA:undetectable","2po7B-6cfpA:undetectable"]]