SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EUG'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		5 / 5 TYR A 108
PHE A 424
ILE A 468
TYR A 503
ARG A 504
 EUG  A1562 (-4.5A)
EUG  A1562 ( 3.7A)
EUG  A1562 (-4.0A)
EUG  A1562 (-4.9A)
FAD  A1561 ( 3.4A)
 0.16A 1qltA-1w1kA:
62.7		 1qltA-1w1kA:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		5 / 5 TYR A 108
PHE A 424
ILE A 468
TYR A 503
ARG A 504
 EUG  A1562 (-4.5A)
EUG  A1562 ( 3.7A)
EUG  A1562 (-4.0A)
EUG  A1562 (-4.9A)
FAD  A1561 ( 3.4A)
 0.16A 1qltB-1w1kA:
62.5		 1qltB-1w1kA:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		5 / 5 TYR A 108
PHE A 424
ILE A 468
TYR A 503
ARG A 504
 EUG  A1562 (-4.5A)
EUG  A1562 ( 3.7A)
EUG  A1562 (-4.0A)
EUG  A1562 (-4.9A)
FAD  A1561 ( 3.4A)
 0.24A 1vaoA-1w1kA:
61.7		 1vaoA-1w1kA:
99.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		5 / 5 TYR A 108
PHE A 424
ILE A 468
TYR A 503
ARG A 504
 EUG  A1562 (-4.5A)
EUG  A1562 ( 3.7A)
EUG  A1562 (-4.0A)
EUG  A1562 (-4.9A)
FAD  A1561 ( 3.4A)
 0.22A 1vaoB-1w1kA:
61.7		 1vaoB-1w1kA:
99.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		4 / 5 HIS A 466
SER A 426
ASP A 170
THR A 459
 EUG  A1562 ( 4.8A)
EUG  A1562 ( 4.8A)
FAD  A1561 ( 3.6A)
EUG  A1562 ( 4.0A)
 1.47A 3okxB-1w1kA:
undetectable		 3okxB-1w1kA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		3 / 3 ILE A 468
ASP A 170
ARG A 504
 EUG  A1562 (-4.0A)
FAD  A1561 ( 3.6A)
FAD  A1561 ( 3.4A)
 0.80A 4pstA-1w1kA:
undetectable		 4pstA-1w1kA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		4 / 6 SER A 426
GLY A 547
ASP A 511
ARG A 114
 EUG  A1562 ( 4.8A)
None
None
None
 0.95A 5cdnT-1w1kA:
2.4
5cdnU-1w1kA:
undetectable		 5cdnT-1w1kA:
23.01
5cdnU-1w1kA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		5 / 9 TYR A 108
VAL A 185
TYR A 187
TYR A 503
ARG A 504
 EUG  A1562 (-4.5A)
EUG  A1562 ( 4.1A)
FAD  A1561 (-4.7A)
EUG  A1562 (-4.9A)
FAD  A1561 ( 3.4A)
 0.58A 5fxfA-1w1kA:
52.7		 5fxfA-1w1kA:
46.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		6 / 10 TYR A 108
ASP A 170
VAL A 185
TYR A 187
TYR A 503
ARG A 504
 EUG  A1562 (-4.5A)
FAD  A1561 ( 3.6A)
EUG  A1562 ( 4.1A)
FAD  A1561 (-4.7A)
EUG  A1562 (-4.9A)
FAD  A1561 ( 3.4A)
 0.56A 5fxfB-1w1kA:
52.9		 5fxfB-1w1kA:
46.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1w1k VANILLYL-ALCOHOL
OXIDASE
(Penicillium
simplicissimum) 		4 / 8 THR A 310
CYH A 470
TRP A 413
LEU A 316
 None
EUG  A1562 ( 4.3A)
FAD  A1561 ( 4.1A)
None
 1.47A 5kxiD-1w1kA:
undetectable
5kxiE-1w1kA:
0.0		 5kxiD-1w1kA:
21.14
5kxiE-1w1kA:
20.77