SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ETX'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4j30 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A  24
GLY A  28
GLY A  29
VAL A  23
GLY A  38
 ETX  A 205 (-4.8A)
ETX  A 205 (-3.3A)
ETX  A 205 (-4.0A)
None
None
 0.93A 1n2xB-4j30A:
undetectable		 1n2xB-4j30A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.30A 1p6kA-2d1gA:
undetectable		 1p6kA-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.27A 1p6kB-2d1gA:
undetectable		 1p6kB-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.34A 1rs6A-2d1gA:
undetectable		 1rs6A-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.32A 1rs6B-2d1gA:
undetectable		 1rs6B-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.30A 1rs7B-2d1gA:
undetectable		 1rs7B-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 4 LEU A  41
SER A  40
TYR A  44
LEU A  46
 ETX  A 152 ( 4.1A)
None
None
ETX  A 152 ( 4.7A)
 1.12A 1xz1A-2hx5A:
undetectable		 1xz1A-2hx5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		4 / 4 LEU A  41
SER A  40
TYR A  44
LEU A  46
 ETX  A 152 ( 4.1A)
None
None
ETX  A 152 ( 4.7A)
 1.12A 1xz3A-2hx5A:
undetectable		 1xz3A-2hx5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.30A 1zzqA-2d1gA:
undetectable		 1zzqA-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzqB-2d1gA:
undetectable		 1zzqB-2d1gA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzuA-2d1gA:
0.5		 1zzuA-2d1gA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2d1g ACID PHOSPHATASE
(Francisella
tularensis) 		4 / 8 SER A 281
ASN A 275
GLN A 347
ASP A 283
 None
None
ETX  A1006 (-3.5A)
None
 1.28A 1zzuB-2d1gA:
undetectable		 1zzuB-2d1gA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 PRO A 210
LEU A 213
ARG A 217
 None
None
ETX  A 501 (-3.5A)
 0.81A 3aqiA-3e49A:
undetectable		 3aqiA-3e49A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD
(Paraburkholderia
xenovorans) 		3 / 3 PRO A 210
LEU A 213
ARG A 217
 None
None
ETX  A 501 (-3.5A)
 0.76A 3aqiB-3e49A:
undetectable		 3aqiB-3e49A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		5 / 12 ILE A 117
ILE A 136
PRO A 133
LEU A  41
VAL A 101
 None
None
None
ETX  A 152 ( 4.1A)
None
 1.07A 4kfjB-2hx5A:
undetectable		 4kfjB-2hx5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		3 / 3 LEU A  66
PRO A  67
ARG A  93
 ETX  A 153 (-4.5A)
ETX  A 153 ( 4.4A)
None
 0.73A 4klrB-2hx5A:
undetectable		 4klrB-2hx5A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4j30 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		5 / 12 ILE A  46
ALA A  71
HIS A  18
VAL A  23
ILE A  35
 None
None
ETX  A 204 ( 3.8A)
None
None
 1.11A 4rvdA-4j30A:
undetectable		 4rvdA-4j30A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4j30 PUTATIVE CYTOPLASMIC
PROTEIN
(Salmonella
enterica) 		4 / 5 GLY A  37
THR A  36
ASN A  34
LYS A  33
 None
ETX  A 205 ( 4.8A)
None
ETX  A 205 (-4.3A)
 1.01A 5x23A-4j30A:
undetectable		 5x23A-4j30A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2hx5 HYPOTHETICAL PROTEIN
(Prochlorococcus
marinus) 		3 / 3 LEU A 140
GLY A 135
PHE A  52
 None
None
ETX  A 152 (-4.3A)
 0.66A 6exiC-2hx5A:
undetectable		 6exiC-2hx5A:
21.23