SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'ERY'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 ASN A 133
ALA A 308
ASN A 333
 ERY  A1400 (-3.6A)
UDP  A1401 (-4.3A)
None
 0.71A 1n4fA-2iyfA:
undetectable		 1n4fA-2iyfA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 6 LEU A 270
ALA A 234
LEU A 236
VAL A 203
 None
ERY  A 402 ( 3.2A)
None
None
 1.17A 1sn5A-5igpA:
undetectable		 1sn5A-5igpA:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
ALA A 182
SER A 183
ASP A 329
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
ERY  A1400 (-4.7A)
 0.02A 2iyfA-2iyfA:
63.9		 2iyfA-2iyfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 12 TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
TYR A 140
ALA A 182
SER A 183
 ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.27A 2iyfB-2iyfA:
58.7		 2iyfB-2iyfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 12 TRP A  73
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
TYR A 140
ALA A 182
SER A 183
ASP A 329
 ERY  A1400 (-3.8A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
ERY  A1400 (-4.7A)
 0.77A 2iyfB-2iyfA:
58.7		 2iyfB-2iyfA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		11 / 12 THR A  17
LYS A  21
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
TYR A 103
VAL A 126
ILE A 150
THR A 154
 ERY  A 195 (-4.4A)
CL  A 198 ( 4.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
ERY  A 195 ( 4.1A)
 0.02A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		11 / 12 THR A  17
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
TYR A 103
SER A 106
VAL A 126
ILE A 150
THR A 154
 ERY  A 195 (-4.4A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.9A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
ERY  A 195 ( 4.1A)
 0.44A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		5 / 5 ASN A 102
ARG A 122
ASN A 123
HIS A 147
ALA A 151
 ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
 0.00A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		12 / 12 THR A  17
LEU A  20
GLY A  62
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
ILE A 105
SER A 106
VAL A 126
ILE A 150
 ERY  A 195 (-4.4A)
None
ERY  A 195 ( 4.1A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 ( 4.3A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
 0.50A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		7 / 7 LYS A  21
ASN A 102
TYR A 103
ARG A 122
ASN A 123
HIS A 147
ALA A 151
 CL  A 198 ( 4.7A)
ERY  A 195 (-3.9A)
ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
 0.53A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
LEU A 134
ALA A 182
SER A 183
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.8A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.05A 4m83A-2iyfA:
undetectable		 4m83A-2iyfA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		11 / 11 HIS A  19
TRP A  73
ASN A  80
VAL A  81
PHE A  84
ILE A 111
TYR A 114
ASN A 133
TYR A 140
ALA A 182
SER A 183
 ERY  A1400 (-3.9A)
ERY  A1400 (-3.8A)
ERY  A1400 (-3.7A)
ERY  A1400 (-4.6A)
ERY  A1400 ( 3.8A)
ERY  A1400 ( 3.8A)
None
ERY  A1400 (-3.6A)
ERY  A1400 ( 4.5A)
ERY  A1400 (-3.6A)
ERY  A1400 (-2.8A)
 0.34A 4m83B-2iyfA:
undetectable		 4m83B-2iyfA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 ASP A 329
ASN A 133
SER A  75
 ERY  A1400 (-4.7A)
ERY  A1400 (-3.6A)
None
 0.85A 4obwA-2iyfA:
4.0		 4obwA-2iyfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3frq REPRESSOR PROTEIN
MPHR(A)
(Escherichia
coli) 		5 / 12 HIS A 147
MET A  93
SER A  92
LEU A  70
PHE A  85
 ERY  A 195 (-4.2A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.6A)
None
None
 1.14A 4qdcA-3frqA:
undetectable		 4qdcA-3frqA:
16.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		12 / 12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
PHE A 280
TYR A 289
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
ERY  A 402 ( 3.6A)
None
 0.48A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		6 / 6 PRO A 112
HIS A 205
GLU A 222
ALA A 233
LEU A 270
TYR A 277
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
None
ERY  A 402 ( 4.5A)
 0.00A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		12 / 12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
GLU A 222
ALA A 233
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
 0.40A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 5 PRO A 112
HIS A 205
LEU A 270
TYR A 277
PHE A 280
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
None
ERY  A 402 ( 4.5A)
ERY  A 402 ( 3.6A)
 0.18A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		12 / 12 MET A 103
ILE A 105
PRO A 112
VAL A 203
GLU A 222
ALA A 233
ALA A 234
VAL A 238
LEU A 270
GLY A 273
THR A 276
TYR A 277
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 ( 4.1A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 4.7A)
None
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
ERY  A 402 ( 4.5A)
 0.28A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGP_A_ERYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 4 ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.00A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGT_A_ERYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 5 MET A 103
ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.2A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.51A 5igtA-5igpA:
48.0		 5igtA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE
(Streptomyces
antibioticus) 		3 / 3 THR A 304
SER A 311
ASP A 329
 None
None
ERY  A1400 (-4.7A)
 0.76A 5kvaA-2iyfA:
undetectable		 5kvaA-2iyfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER
(Mycobacterium
tuberculosis) 		11 / 11 GLU A 196
GLU A 199
ARG A 200
GLY A 285
ASP A 286
ALA A 307
ALA A 309
PRO A 310
ILE A 407
ARG A 410
VAL A 411
 ERY  A 501 (-2.9A)
ERY  A 501 ( 4.0A)
None
ERY  A 501 ( 3.7A)
ERY  A 501 (-4.2A)
ERY  A 501 (-3.8A)
ERY  A 501 (-3.3A)
ERY  A 501 ( 4.7A)
ERY  A 501 (-4.1A)
ERY  A 501 (-4.1A)
None
 0.06A 5yk2A-5yk2A:
57.7		 5yk2A-5yk2A:
undetectable