SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EQ3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_A_9CRA501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	5 / 12	ILE A 305 ALA A 304 LEU A 225 ALA A 224 VAL A 275	EQ3 A 403 ( 3.8A) None None None EQ3 A 403 (-4.7A)	1.00A	1fm6A-5ui2A: undetectable	1fm6A-5ui2A: 23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z9H_D_IMND476_1 (MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	5 / 12	PRO A 228 PRO A 103 ILE A 288 VAL A 275 LEU A 252	None None None EQ3 A 403 (-4.7A) EQ3 A 403 (-4.4A)	1.18A	1z9hD-5ui2A: undetectable	1z9hD-5ui2A: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IX9_A_MTXA200_1 (DIHYDROFOLATE REDUCTASE)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	5 / 12	ILE A 40 TRP A 41 ALA A 38 LEU A 131 LEU A 31	EQ3 A 403 (-3.9A) None None None None	0.96A	3ix9A-5ui2A: undetectable	3ix9A-5ui2A: 19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JAY_A_SAMA1102_0 (STRUCTURAL PROTEIN VP3)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	5 / 12	ILE A 151 GLY A 148 ALA A 18 PHE A 280 ILE A 145	EQ3 A 403 (-3.9A) None None EQ3 A 403 ( 4.7A) None	0.90A	3jayA-5ui2A: undetectable	3jayA-5ui2A: 15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB1_A_SAMA1101_0 (STRUCTURAL PROTEIN VP3)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	5 / 12	ILE A 151 GLY A 148 ALA A 18 PHE A 280 ILE A 145	EQ3 A 403 (-3.9A) None None EQ3 A 403 ( 4.7A) None	1.00A	3jb1A-5ui2A: undetectable	3jb1A-5ui2A: 15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4V2Z_C_Y70C151_1 (CEREBLON ISOFORM 4)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	4 / 8	PRO A 228 PHE A 242 TRP A 290 TYR A 203	None None EQ3 A 403 (-4.2A) EQ3 A 403 (-4.6A)	1.30A	4v2zC-5ui2A: undetectable	4v2zC-5ui2A: 17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UAN_A_9CRA503_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ui2	ORANGE CAROTENOID-BINDING PROTEIN (Arthrospira maxima)	5 / 12	ILE A 305 ALA A 304 LEU A 225 ALA A 224 VAL A 275	EQ3 A 403 ( 3.8A) None None None EQ3 A 403 (-4.7A)	0.95A	5uanA-5ui2A: undetectable	5uanA-5ui2A: 20.90

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FM6_A_9CRA501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",5,"ILE A 305;ALA A 304;LEU A 225;ALA A 224;VAL A 275","EQ3 A 403 ( 3.8A);None;None;None;EQ3 A 403 (-4.7A)","1.00A","1fm6A-5ui2A:undetectable",null],["1Z9H_D_IMND476_1","MEMBRANE-ASSOCIATED PROSTAGLANDIN E SYNTHASE-2","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",5,"PRO A 228;PRO A 103;ILE A 288;VAL A 275;LEU A 252","None;None;None;EQ3 A 403 (-4.7A);EQ3 A 403 (-4.4A)","1.18A","1z9hD-5ui2A:undetectable","1fm6A-5ui2A:23.56"],["3IX9_A_MTXA200_1","DIHYDROFOLATE REDUCTASE","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",5,"ILE A  40;TRP A  41;ALA A  38;LEU A 131;LEU A  31","EQ3 A 403 (-3.9A);None;None;None;None","0.96A","3ix9A-5ui2A:undetectable","1z9hD-5ui2A:19.35"],["3JAY_A_SAMA1102_0","STRUCTURAL PROTEIN VP3","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",5,"ILE A 151;GLY A 148;ALA A  18;PHE A 280;ILE A 145","EQ3 A 403 (-3.9A);None;None;EQ3 A 403 ( 4.7A);None","0.90A","3jayA-5ui2A:undetectable","3ix9A-5ui2A:19.88"],["3JB1_A_SAMA1101_0","STRUCTURAL PROTEIN VP3","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",5,"ILE A 151;GLY A 148;ALA A  18;PHE A 280;ILE A 145","EQ3 A 403 (-3.9A);None;None;EQ3 A 403 ( 4.7A);None","1.00A","3jb1A-5ui2A:undetectable","3jayA-5ui2A:15.07"],["4V2Z_C_Y70C151_1","CEREBLON ISOFORM 4","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",4,"PRO A 228;PHE A 242;TRP A 290;TYR A 203","None;None;EQ3 A 403 (-4.2A);EQ3 A 403 (-4.6A)","1.30A","4v2zC-5ui2A:undetectable","3jb1A-5ui2A:15.07"],["5UAN_A_9CRA503_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5ui2","ORANGE CAROTENOID-BINDING PROTEIN","Arthrospira maxima",5,"ILE A 305;ALA A 304;LEU A 225;ALA A 224;VAL A 275","EQ3 A 403 ( 3.8A);None;None;None;EQ3 A 403 (-4.7A)","0.95A","5uanA-5ui2A:undetectable","4v2zC-5ui2A:17.55"]]