SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EPU'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 7 SER A 180
VAL A 150
GLY A  30
ILE A  34
 None
None
EPU  A 598 (-3.2A)
None
 0.84A 1gtnC-1p31A:
undetectable
1gtnD-1p31A:
undetectable		 1gtnC-1p31A:
9.66
1gtnD-1p31A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		6 / 10 LEU A 111
ILE A  26
GLY A  27
GLY A  28
VAL A 150
ILE A  34
 None
None
EPU  A 598 (-3.7A)
EPU  A 598 (-3.2A)
None
None
 1.25A 1sdtA-1p31A:
undetectable		 1sdtA-1p31A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		5 / 11 LEU A 111
ILE A  26
GLY A  27
GLY A  28
ILE A  34
 None
None
EPU  A 598 (-3.7A)
EPU  A 598 (-3.2A)
None
 1.05A 1sduA-1p31A:
undetectable		 1sduA-1p31A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		3 / 3 SER A 229
GLY A 228
ARG A 214
 EPU  A 402 (-3.0A)
EPU  A 402 ( 3.5A)
FAD  A 401 ( 2.8A)
 0.65A 1t9wA-2mbrA:
2.1		 1t9wA-2mbrA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		5 / 12 ALA A  64
GLY A  25
GLY A  27
ILE A  66
ILE A  87
 None
EPU  A 598 (-3.5A)
EPU  A 598 (-3.7A)
None
EPU  A 598 (-4.9A)
 1.12A 1x1aA-1p31A:
4.9		 1x1aA-1p31A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 168
SER A 165
VAL A 194
LEU A  97
 None
EPU  A 501 (-2.8A)
None
None
 1.24A 1yajB-5bq2A:
undetectable		 1yajB-5bq2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		4 / 4 GLY A 168
SER A 165
VAL A 194
LEU A  97
 None
EPU  A 501 (-2.5A)
None
None
 1.25A 1yajB-6cn1A:
undetectable		 1yajB-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 8 LEU A 184
ARG A 118
GLY A  33
MET A  31
 None
None
None
EPU  A 598 (-4.5A)
 0.75A 2po5A-1p31A:
2.7		 2po5A-1p31A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 8 LEU A 184
ARG A 118
GLY A  33
MET A  31
 None
None
None
EPU  A 598 (-4.5A)
 0.77A 2po5B-1p31A:
3.3		 2po5B-1p31A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		3 / 3 ARG A 159
SER A 229
TYR A 158
 FAD  A 401 ( 3.2A)
EPU  A 402 (-3.0A)
EPU  A 402 (-4.2A)
 0.99A 2q2hA-2mbrA:
undetectable
2q2hB-2mbrA:
undetectable		 2q2hA-2mbrA:
17.65
2q2hB-2mbrA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 7 LEU A 184
ARG A 118
GLY A  33
MET A  31
 None
None
None
EPU  A 598 (-4.5A)
 1.05A 3hcrB-1p31A:
2.1		 3hcrB-1p31A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		5 / 11 LEU A 111
ILE A  26
GLY A  28
VAL A 150
ILE A  34
 None
None
EPU  A 598 (-3.2A)
None
None
 1.20A 3oxxB-1p31A:
undetectable		 3oxxB-1p31A:
13.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  22
ARG A 122
LEU A 373
 EPU  A 501 (-2.6A)
EPU  A 501 (-3.9A)
EPU  A 501 (-4.5A)
 0.60A 3v4tE-5bq2A:
63.6		 3v4tE-5bq2A:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A  22
ARG A 334
LEU A 373
 EPU  A 501 (-2.6A)
EPU  A 501 ( 4.2A)
EPU  A 501 (-4.5A)
 1.08A 3v4tE-5bq2A:
63.6		 3v4tE-5bq2A:
60.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		3 / 3 LYS A  22
ARG A 122
LEU A 373
 EPU  A 501 (-4.1A)
EPU  A 501 (-3.9A)
EPU  A 501 (-4.6A)
 1.07A 3v4tE-6cn1A:
63.6		 3v4tE-6cn1A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 7 ARG A  93
ALA A  94
ILE A  96
ARG A 122
HIS A 127
 QPA  A 117 ( 4.3A)
EPU  A 501 ( 3.7A)
None
EPU  A 501 (-3.9A)
EPU  A 501 ( 4.8A)
 0.57A 3v4tH-5bq2A:
63.7		 3v4tH-5bq2A:
60.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 7 ALA A  97
ILE A  99
ARG A 125
HIS A 130
GLY A 168
 EPU  A 503 (-3.4A)
None
EPU  A 503 (-4.0A)
EPU  A 503 ( 4.9A)
EPU  A 503 (-3.3A)
 0.65A 3v4tH-5wi5A:
60.5		 3v4tH-5wi5A:
50.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 7 ARG A  96
ALA A  97
ILE A  99
ARG A 125
HIS A 130
 None
EPU  A 503 (-3.4A)
None
EPU  A 503 (-4.0A)
EPU  A 503 ( 4.9A)
 0.79A 3v4tH-5wi5A:
60.5		 3v4tH-5wi5A:
50.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		5 / 7 ARG A  93
ALA A  94
ILE A  96
ARG A 122
HIS A 127
 None
EPU  A 501 (-3.6A)
None
EPU  A 501 (-3.9A)
None
 0.60A 3v4tH-6cn1A:
63.8		 3v4tH-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		4 / 7 ILE A  96
ARG A 122
HIS A 127
GLY A 168
 None
EPU  A 501 (-3.9A)
None
None
 1.01A 3v4tH-6cn1A:
63.8		 3v4tH-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		3 / 3 ARG A 374
LYS A  22
ARG A 400
 None
EPU  A 501 (-4.1A)
0V5  A 502 (-3.0A)
 1.48A 3w1wA-6cn1A:
undetectable
3w1wB-6cn1A:
undetectable		 3w1wA-6cn1A:
undetectable
3w1wB-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		3 / 3 ARG A 400
ARG A 374
LYS A  22
 0V5  A 502 (-3.0A)
None
EPU  A 501 (-4.1A)
 1.47A 3w1wA-6cn1A:
undetectable
3w1wB-6cn1A:
undetectable		 3w1wA-6cn1A:
undetectable
3w1wB-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		5 / 12 SER A  32
GLY A  53
GLY A  27
GLY A  28
ASP A  52
 None
None
EPU  A 598 (-3.7A)
EPU  A 598 (-3.2A)
None
 1.10A 4b17A-1p31A:
undetectable		 4b17A-1p31A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		5 / 12 TYR A 190
GLN A 288
ALA A 264
GLN A 256
GLY A 123
 EPU  A 402 (-4.1A)
EPU  A 402 (-3.1A)
EPU  A 402 (-3.4A)
None
FAD  A 401 (-4.1A)
 1.12A 4iilA-2mbrA:
undetectable		 4iilA-2mbrA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		5 / 12 LEU A  97
GLU A 170
LEU A 197
ILE A  74
LEU A  34
 None
EPU  A 501 ( 4.9A)
None
None
None
 1.14A 4j24A-6cn1A:
undetectable		 4j24A-6cn1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		5 / 12 LEU A  97
GLU A 170
LEU A 197
ILE A  74
LEU A  34
 None
EPU  A 501 ( 4.9A)
None
None
None
 1.10A 4j24B-6cn1A:
undetectable		 4j24B-6cn1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		5 / 12 LEU A  97
GLU A 170
LEU A 197
ILE A  74
LEU A  34
 None
EPU  A 501 ( 4.9A)
None
None
None
 1.14A 4j24C-6cn1A:
undetectable		 4j24C-6cn1A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 6 ARG A 107
GLY A  28
ASP A 175
HIS A 198
 EPU  A 598 (-3.8A)
EPU  A 598 (-3.2A)
EPU  A 598 (-3.4A)
MG  A 776 ( 3.5A)
 1.26A 4lajA-1p31A:
undetectable
4lajB-1p31A:
undetectable		 4lajA-1p31A:
22.34
4lajB-1p31A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		5 / 12 GLY A  27
GLY A  25
PHE A  23
THR A 130
GLY A  33
 EPU  A 598 (-3.7A)
EPU  A 598 (-3.5A)
None
None
None
 1.12A 4n48A-1p31A:
undetectable		 4n48A-1p31A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		5 / 12 GLY A  27
GLY A  25
PHE A  23
THR A 130
GLY A  33
 EPU  A 598 (-3.7A)
EPU  A 598 (-3.5A)
None
None
None
 1.10A 4n48B-1p31A:
undetectable		 4n48B-1p31A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 235
ASP A 308
GLU A 237
VAL A 380
 None
EPU  A 501 (-2.9A)
None
None
 1.41A 4nkvB-5bq2A:
undetectable		 4nkvB-5bq2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 6 GLU A 192
ASP A 309
GLU A 329
ARG A 125
 EPU  A 503 ( 4.9A)
EPU  A 503 (-2.8A)
None
EPU  A 503 (-4.0A)
 1.12A 4ntxA-5wi5A:
undetectable
4ntxC-5wi5A:
undetectable		 4ntxA-5wi5A:
20.62
4ntxC-5wi5A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		5 / 12 THR A 299
GLN A 310
ASP A 372
ILE A 330
PHE A 331
 None
None
None
EPU  A 501 (-4.8A)
EPU  A 501 (-4.8A)
 1.39A 4rp9A-6cn1A:
undetectable		 4rp9A-6cn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 LYS A 217
LEU A 218
ASN A 226
PRO A 219
 EPU  A 402 (-3.6A)
EPU  A 402 ( 4.6A)
FAD  A 401 (-3.5A)
None
 1.37A 4yv5B-2mbrA:
undetectable		 4yv5B-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 PHE A 318
LEU A 322
ASN A 233
PRO A 234
 None
None
EPU  A 402 (-2.9A)
None
 1.30A 4yv5B-2mbrA:
undetectable		 4yv5B-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 LYS A 217
LEU A 218
ASN A 226
PRO A 219
 EPU  A 402 (-3.6A)
EPU  A 402 ( 4.6A)
FAD  A 401 (-3.5A)
None
 1.40A 4yv5A-2mbrA:
undetectable		 4yv5A-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE
(Escherichia
coli) 		4 / 6 PHE A 318
LEU A 322
ASN A 233
PRO A 234
 None
None
EPU  A 402 (-2.9A)
None
 1.31A 4yv5A-2mbrA:
undetectable		 4yv5A-2mbrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 5 THR A  56
GLY A  27
HIS A  74
ASP A  52
 None
EPU  A 598 (-3.7A)
None
None
 1.25A 5c0oH-1p31A:
4.8		 5c0oH-1p31A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE
(Haemophilus
influenzae) 		4 / 6 SER A 177
GLU A 176
GLY A  25
GLY A  28
 EPU  A 598 (-3.1A)
MG  A 776 ( 4.1A)
EPU  A 598 (-3.5A)
EPU  A 598 (-3.2A)
 0.95A 5cdpA-1p31A:
0.0
5cdpB-1p31A:
undetectable		 5cdpA-1p31A:
23.77
5cdpB-1p31A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A  94
PRO A 114
VAL A  89
ASP A  49
 EPU  A 501 ( 3.7A)
None
None
None
 0.92A 5umd2-5bq2A:
undetectable
5umdF-5bq2A:
undetectable		 5umd2-5bq2A:
10.50
5umdF-5bq2A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 6 ALA A  97
PRO A 117
VAL A  92
ASP A  51
 EPU  A 503 (-3.4A)
None
None
None
 0.93A 5umd2-5wi5A:
undetectable
5umdF-5wi5A:
undetectable		 5umd2-5wi5A:
12.61
5umdF-5wi5A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 6cn1 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
putida) 		4 / 6 ALA A  94
PRO A 114
VAL A  89
ASP A  49
 EPU  A 501 (-3.6A)
None
None
None
 0.90A 5umd2-6cn1A:
undetectable
5umdF-6cn1A:
undetectable		 5umd2-6cn1A:
18.07
5umdF-6cn1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		5 / 12 PRO A  47
ARG A 375
ARG A 236
VAL A 167
GLN A 171
 None
None
None
EPU  A 503 (-3.8A)
EPU  A 503 ( 4.8A)
 1.39A 5wggA-5wi5A:
0.2		 5wggA-5wi5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 5bq2 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 122
ILE A 119
ASN A  23
ARG A 400
ASP A  49
 EPU  A 501 (-3.9A)
QPA  A 117 ( 3.9A)
EPU  A 501 (-3.1A)
QPA  A 117 ( 3.0A)
None
 1.34A 6ekuA-5bq2A:
undetectable		 6ekuA-5bq2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1
(Streptococcus
pneumoniae) 		4 / 6 LEU A 399
ALA A 378
LEU A  49
ASN A  24
 None
None
None
EPU  A 503 (-3.1A)
 0.96A 6f88B-5wi5A:
undetectable		 6f88B-5wi5A:
11.94