SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EPS'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 SER A   9
HIS A  10
LEU A 128
SER A 132
 EPS  A5001 ( 4.3A)
EPS  A5001 (-4.4A)
None
EPS  A5001 (-3.5A)
 0.41A 2qhfA-1qxoA:
49.6		 2qhfA-1qxoA:
44.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		9 / 11 ARG A  39
ARG A  45
ALA A 133
THR A 136
ILE A 250
MET A 310
ALA A 342
ALA A 346
VAL A 349
 EPS  A5001 (-2.8A)
EPS  A5001 ( 2.7A)
FMN  A4001 ( 3.3A)
FMN  A4001 ( 4.5A)
None
None
FMN  A4001 (-3.5A)
FMN  A4001 ( 4.0A)
None
 0.47A 2qhfA-1qxoA:
49.5		 2qhfA-1qxoA:
44.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A 337
GLY A  47
SER A 132
 None
None
EPS  A5001 (-3.5A)
 0.62A 2xctB-1qxoA:
undetectable		 2xctB-1qxoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 7 ARG A  39
ARG A  45
ALA A 342
VAL A 349
 EPS  A5001 (-2.8A)
EPS  A5001 ( 2.7A)
FMN  A4001 (-3.5A)
None
 0.80A 3o14A-1qxoA:
undetectable		 3o14A-1qxoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 HIS A 110
SER A 132
ASP A 339
THR A 315
 FMN  A4001 ( 3.8A)
EPS  A5001 (-3.5A)
FMN  A4001 ( 4.9A)
FMN  A4001 (-2.9A)
 1.12A 3okxA-1qxoA:
0.0		 3okxA-1qxoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 HIS A 110
SER A 132
ASP A 339
THR A 315
 FMN  A4001 ( 3.8A)
EPS  A5001 (-3.5A)
FMN  A4001 ( 4.9A)
FMN  A4001 (-2.9A)
 1.07A 3okxB-1qxoA:
0.0		 3okxB-1qxoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 SER A 132
THR A 315
ARG A  39
ALA A 133
THR A 136
 EPS  A5001 (-3.5A)
FMN  A4001 (-2.9A)
EPS  A5001 (-2.8A)
FMN  A4001 ( 3.3A)
FMN  A4001 ( 4.5A)
 1.50A 5l5fV-1qxoA:
0.0
5l5fb-1qxoA:
0.0		 5l5fV-1qxoA:
22.16
5l5fb-1qxoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 SER A 132
THR A 315
ARG A  39
ALA A 133
THR A 136
 EPS  A5001 (-3.5A)
FMN  A4001 (-2.9A)
EPS  A5001 (-2.8A)
FMN  A4001 ( 3.3A)
FMN  A4001 ( 4.5A)
 1.49A 5l5fH-1qxoA:
0.0
5l5fN-1qxoA:
0.0		 5l5fH-1qxoA:
22.16
5l5fN-1qxoA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 ARG A 134
GLU A 129
GLY A   7
LEU A  14
 EPS  A5001 (-4.1A)
None
None
None
 0.96A 5sxqA-1qxoA:
undetectable		 5sxqA-1qxoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 ARG A 134
GLU A 129
GLY A   7
LEU A  14
 EPS  A5001 (-4.1A)
None
None
None
 0.96A 5syjB-1qxoA:
undetectable		 5syjB-1qxoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 MET A  88
ASP A 123
ARG A 107
 None
None
EPS  A5001 ( 4.4A)
 1.16A 5z6jA-1qxoA:
undetectable		 5z6jA-1qxoA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 MET A  88
ASP A 123
ARG A 107
 None
None
EPS  A5001 ( 4.4A)
 1.20A 5z6kA-1qxoA:
undetectable		 5z6kA-1qxoA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1qxo CHORISMATE SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLN A  40
THR A 137
ARG A  39
SER A   9
 None
EPS  A5001 ( 4.9A)
EPS  A5001 (-2.8A)
EPS  A5001 ( 4.3A)
 1.03A 6c06C-1qxoA:
undetectable		 6c06C-1qxoA:
undetectable