SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EPC'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		4 / 8 LEU A  87
GLY A  88
ILE A 139
MET A 136
 EPC  A1395 ( 3.8A)
None
None
None
 0.84A 1n13A-2vd9A:
undetectable
1n13F-2vd9A:
undetectable		 1n13A-2vd9A:
11.21
1n13F-2vd9A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		5 / 12 GLY A 226
GLY A 231
VAL A  39
ALA A  38
LEU A  87
 IN5  A1394 ( 3.2A)
None
IN5  A1394 (-4.6A)
None
EPC  A1395 ( 3.8A)
 0.86A 1vptA-2vd9A:
undetectable		 1vptA-2vd9A:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		4 / 8 LYS A  41
TYR A  45
ARG A 138
TYR A 359
 IN5  A1394 ( 2.4A)
IN5  A1394 ( 4.4A)
IN5  A1394 (-3.1A)
EPC  A1395 ( 4.2A)
 0.24A 1xqlA-2vd9A:
53.9
1xqlB-2vd9A:
53.6		 1xqlA-2vd9A:
56.30
1xqlB-2vd9A:
56.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		4 / 8 LYS A  41
TYR A  45
ARG A 138
TYR A 359
 IN5  A1394 ( 2.4A)
IN5  A1394 ( 4.4A)
IN5  A1394 (-3.1A)
EPC  A1395 ( 4.2A)
 0.37A 1xqlA-2vd9A:
53.9
1xqlB-2vd9A:
53.6		 1xqlA-2vd9A:
56.30
1xqlB-2vd9A:
56.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		4 / 8 ILE A 139
MET A 136
LEU A  87
GLY A  88
 None
None
EPC  A1395 ( 3.8A)
None
 0.88A 2qqcH-2vd9A:
undetectable
2qqcK-2vd9A:
undetectable		 2qqcH-2vd9A:
14.58
2qqcK-2vd9A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		4 / 8 ILE A 139
MET A 136
LEU A  87
GLY A  88
 None
None
EPC  A1395 ( 3.8A)
None
 0.82A 2qqdB-2vd9A:
undetectable
2qqdC-2vd9A:
undetectable		 2qqdB-2vd9A:
14.83
2qqdC-2vd9A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		4 / 5 ILE A 362
HIS A  47
TYR A 359
GLY A 226
 None
None
EPC  A1395 ( 4.2A)
IN5  A1394 ( 3.2A)
 1.29A 3b9mA-2vd9A:
undetectable		 3b9mA-2vd9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2vd9 ALANINE RACEMASE
(Bacillus
anthracis) 		5 / 12 GLY A  88
ALA A  67
ILE A 139
LEU A  85
HIS A 168
 None
None
None
None
EPC  A1395 ( 3.6A)
 1.29A 4azsA-2vd9A:
undetectable		 4azsA-2vd9A:
21.78