SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EPB'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 9 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.23A 1hwiA-1q5dA:
undetectable		 1hwiA-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 8 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.20A 1hwiD-1q5dA:
undetectable		 1hwiD-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 11 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.25A 1hwkB-1q5dA:
0.0		 1hwkB-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 11 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.22A 1hwkA-1q5dA:
undetectable		 1hwkA-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 11 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.23A 1hwkD-1q5dA:
0.0		 1hwkD-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 11 CYH A 365
HIS A 103
LEU A  95
ALA A 250
LEU A 247
 HEM  A 440 (-2.3A)
HEM  A 440 (-3.9A)
HEM  A 440 (-3.7A)
EPB  A 450 ( 3.7A)
None
 1.24A 1hwkC-1q5dA:
0.4		 1hwkC-1q5dA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 12 MET A 325
PHE A  96
LEU A 187
PRO A 401
VAL A 191
 None
EPB  A 450 ( 3.6A)
None
None
None
 1.24A 2po7B-1q5dA:
undetectable		 2po7B-1q5dA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		4 / 7 ALA A 180
THR A 179
ALA A 178
ARG A 174
 EPB  A 450 (-3.3A)
None
None
None
 0.99A 2ql8A-1q5dA:
undetectable
2ql8B-1q5dA:
0.0		 2ql8A-1q5dA:
14.94
2ql8B-1q5dA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 12 MET A 325
PHE A  96
LEU A 187
PRO A 401
VAL A 191
 None
EPB  A 450 ( 3.6A)
None
None
None
 1.23A 3w1wA-1q5dA:
undetectable		 3w1wA-1q5dA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		5 / 12 VAL A 191
ASP A 192
GLU A 193
LEU A 183
ALA A 182
 None
None
None
EPB  A 450 (-4.3A)
None
 1.05A 5nd4B-1q5dA:
undetectable		 5nd4B-1q5dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 1q5d P450 EPOXIDASE
(Sorangium
cellulosum) 		4 / 5 PHE A  96
VAL A 110
PRO A 362
VAL A  69
 EPB  A 450 ( 3.6A)
None
None
None
 1.39A 6ekzA-1q5dA:
undetectable		 6ekzA-1q5dA:
13.68