SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EPA'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V57_A_PRLA1188_0 (TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR)	5m0o	TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE (Jeotgalicoccus sp. ATCC 8456)	4 / 8	ILE A 170 TYR A 21 ASP A 171 ARG A 174	EPA A 502 (-4.3A) None None None	0.90A	2v57A-5m0oA: undetectable	2v57A-5m0oA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V57_C_PRLC1187_0 (TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR)	5m0o	TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE (Jeotgalicoccus sp. ATCC 8456)	4 / 8	ILE A 170 TYR A 21 ASP A 171 ARG A 174	EPA A 502 (-4.3A) None None None	0.90A	2v57C-5m0oA: undetectable	2v57C-5m0oA: 21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_A_BCZA468_1 (NEURAMINIDASE)	5m0o	TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE (Jeotgalicoccus sp. ATCC 8456)	3 / 3	ASP A 239 ARG A 95 ARG A 245	None None EPA A 502 (-3.8A)	1.05A	3k37A-5m0oA: undetectable	3k37A-5m0oA: 20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3VM4_A_IZPA1_1 (FATTY ACID ALPHA-HYDROXYLASE)	5m0o	TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE (Jeotgalicoccus sp. ATCC 8456)	4 / 5	LEU A 78 ARG A 245 PRO A 246 ALA A 249	None EPA A 502 (-3.8A) EPA A 502 ( 3.7A) HEM A 501 (-3.9A)	0.38A	3vm4A-5m0oA: 55.7	3vm4A-5m0oA: 37.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2V57_A_PRLA1188_0","TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR","5m0o","TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE","Jeotgalicoccus sp. ATCC 8456",4,"ILE A 170;TYR A  21;ASP A 171;ARG A 174","EPA A 502 (-4.3A);None;None;None","0.90A","2v57A-5m0oA:undetectable",null],["2V57_C_PRLC1187_0","TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR","5m0o","TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE","Jeotgalicoccus sp. ATCC 8456",4,"ILE A 170;TYR A  21;ASP A 171;ARG A 174","EPA A 502 (-4.3A);None;None;None","0.90A","2v57C-5m0oA:undetectable","2v57A-5m0oA:21.57"],["3K37_A_BCZA468_1","NEURAMINIDASE","5m0o","TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE","Jeotgalicoccus sp. ATCC 8456",3,"ASP A 239;ARG A  95;ARG A 245","None;None;EPA A 502 (-3.8A)","1.05A","3k37A-5m0oA:undetectable","2v57C-5m0oA:21.57"],["3VM4_A_IZPA1_1","FATTY ACID ALPHA-HYDROXYLASE","5m0o","TERMINAL OLEFIN-FORMING FATTY ACID DECARBOXYLASE","Jeotgalicoccus sp. ATCC 8456",4,"LEU A  78;ARG A 245;PRO A 246;ALA A 249","None;EPA A 502 (-3.8A);EPA A 502 ( 3.7A);HEM A 501 (-3.9A)","0.38A","3vm4A-5m0oA:55.7","3k37A-5m0oA:20.83"]]