SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EP5'


List of Similar Pattern of Amino Acids


Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
1.09A 2y00A-6g79S:
28.3
2y00A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.84A 2y00A-6g79S:
28.3
2y00A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
1.12A 2y00B-6g79S:
28.3
2y00B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.82A 2y00B-6g79S:
28.3
2y00B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
7 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TRP S 356
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
None
EP5  S 401 ( 4.9A)
1.06A 2y01A-6g79S:
28.2
2y01A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.80A 2y01B-6g79S:
28.2
2y01B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
1.14A 2y01B-6g79S:
28.2
2y01B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.79A 2y03A-6g79S:
28.3
2y03A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
0.98A 2y03A-6g79S:
28.3
2y03A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.76A 2y03B-6g79S:
28.2
2y03B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
0.98A 2y03B-6g79S:
28.2
2y03B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 11 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.74A 2y04A-6g79S:
28.1
2y04A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_A_68HA601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 11 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
1.13A 2y04A-6g79S:
28.1
2y04A-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.65A 2y04B-6g79S:
28.2
2y04B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
1.09A 2y04B-6g79S:
28.2
2y04B-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.58A 3d4sA-6g79S:
27.9
3d4sA-6g79S:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.64A 3nyaA-6g79S:
27.8
3nyaA-6g79S:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
1.00A 3nyaA-6g79S:
27.8
3nyaA-6g79S:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 ASP S 129
THR S 134
TRP S 327
PHE S 331
TYR S 359
EP5  S 401 (-3.3A)
EP5  S 401 (-3.8A)
None
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.83A 3rzeA-6g79S:
28.0
3rzeA-6g79S:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
1.17A 4amjA-6g79S:
28.2
4amjA-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
7 / 12 TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.70A 4amjA-6g79S:
28.2
4amjA-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
1.16A 4amjB-6g79S:
28.4
4amjB-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_B_CVDB1360_1
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
7 / 12 TRP S 125
ASP S 129
SER S 212
TRP S 327
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.68A 4amjB-6g79S:
28.4
4amjB-6g79S:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
4 / 7 THR S 355
TYR S 109
LEU S 126
PHE S 330
None
None
None
EP5  S 401 (-4.0A)
1.35A 4awuA-6g79S:
undetectable
4awuA-6g79S:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 ALA S 216
TRP S 327
PHE S 330
PHE S 331
PHE S 351
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 (-4.5A)
1.07A 4iaqA-6g79S:
34.2
4iaqA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
9 / 12 LEU S 126
ASP S 129
CYH S 133
VAL S 201
ALA S 216
TRP S 327
PHE S 330
PHE S 331
THR S 355
None
EP5  S 401 (-3.3A)
EP5  S 401 (-4.2A)
EP5  S 401 (-4.1A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
None
0.63A 4iaqA-6g79S:
34.2
4iaqA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
4 / 6 TRP S 125
ILE S 130
THR S 134
SER S 212
None
EP5  S 401 (-4.2A)
EP5  S 401 (-3.8A)
EP5  S 401 (-3.3A)
0.72A 4iaqA-6g79S:
34.2
4iaqA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 CYH S 133
TRP S 327
PHE S 330
MET S 337
THR S 355
EP5  S 401 (-4.2A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.0A)
None
1.50A 4iarA-6g79S:
34.6
4iarA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
8 / 12 LEU S 126
ASP S 129
CYH S 133
VAL S 201
ALA S 216
TRP S 327
PHE S 330
THR S 355
None
EP5  S 401 (-3.3A)
EP5  S 401 (-4.2A)
EP5  S 401 (-4.1A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
None
0.62A 4iarA-6g79S:
34.6
4iarA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
7 / 12 LEU S 126
ASP S 129
CYH S 133
VAL S 201
ALA S 216
TRP S 327
SER S 334
None
EP5  S 401 (-3.3A)
EP5  S 401 (-4.2A)
EP5  S 401 (-4.1A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-3.6A)
0.81A 4iarA-6g79S:
34.6
4iarA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
4 / 7 TRP S 125
ILE S 130
SER S 212
PHE S 331
None
EP5  S 401 (-4.2A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.7A)
0.74A 4iarA-6g79S:
34.6
4iarA-6g79S:
95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
4 / 7 TRP S 125
ILE S 130
THR S 134
PHE S 331
None
EP5  S 401 (-4.2A)
EP5  S 401 (-3.8A)
EP5  S 401 (-4.7A)
0.43A 4iarA-6g79S:
34.6
4iarA-6g79S:
95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 LEU S 126
ALA S 216
TRP S 327
PHE S 330
PHE S 331
None
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
0.50A 4ib4A-6g79S:
28.1
4ib4A-6g79S:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 LEU S 126
ASP S 129
ALA S 216
TRP S 327
PHE S 330
None
EP5  S 401 (-3.3A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
0.53A 4nc3A-6g79S:
28.8
4nc3A-6g79S:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 LEU S 126
ASP S 129
ALA S 216
PHE S 330
PHE S 331
None
EP5  S 401 (-3.3A)
EP5  S 401 ( 4.0A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
0.45A 5tudA-6g79S:
30.4
5tudA-6g79S:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
7 / 12 SER S 106
TRP S 125
THR S 134
TRP S 327
PHE S 330
PHE S 331
TYR S 359
None
None
EP5  S 401 (-3.8A)
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.81A 6a93A-6g79S:
24.9
6a93A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 THR S 134
PHE S 323
TRP S 327
PHE S 330
PHE S 331
EP5  S 401 (-3.8A)
None
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
1.34A 6a93A-6g79S:
24.9
6a93A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 SER S 106
TRP S 125
THR S 134
PHE S 330
PHE S 331
None
None
EP5  S 401 (-3.8A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
0.79A 6a93B-6g79S:
26.4
6a93B-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 SER S 106
TRP S 125
TRP S 327
PHE S 330
PHE S 331
None
None
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
0.72A 6a93B-6g79S:
26.4
6a93B-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 CYH S 133
THR S 134
PHE S 331
TYR S 109
TYR S 359
EP5  S 401 (-4.2A)
EP5  S 401 (-3.8A)
EP5  S 401 (-4.7A)
None
EP5  S 401 ( 4.9A)
1.34A 6cm4A-6g79S:
25.8
6cm4A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 CYH S 133
THR S 134
TRP S 327
THR S 355
TYR S 359
EP5  S 401 (-4.2A)
EP5  S 401 (-3.8A)
None
None
EP5  S 401 ( 4.9A)
0.82A 6cm4A-6g79S:
25.8
6cm4A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_0
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 CYH S 133
TRP S 327
PHE S 331
THR S 355
TYR S 359
EP5  S 401 (-4.2A)
None
EP5  S 401 (-4.7A)
None
EP5  S 401 ( 4.9A)
0.90A 6cm4A-6g79S:
25.8
6cm4A-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 LEU S 126
THR S 134
ALA S 216
TRP S 327
PHE S 330
TYR S 359
None
EP5  S 401 (-3.8A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
0.60A 6drxA-6g79S:
28.9
6drxA-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
LEU S 126
THR S 134
ALA S 216
TRP S 327
TYR S 359
None
None
EP5  S 401 (-3.8A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 ( 4.9A)
0.58A 6drxA-6g79S:
28.9
6drxA-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 11 ASP S 129
THR S 134
ALA S 216
PHE S 330
TYR S 359
EP5  S 401 (-3.3A)
EP5  S 401 (-3.8A)
EP5  S 401 ( 4.0A)
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
0.45A 6dryA-6g79S:
26.5
6dryA-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.75A 6h7jA-6g79S:
32.5
6h7jA-6g79S:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.75A 6h7jB-6g79S:
33.1
6h7jB-6g79S:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.76A 6h7mA-6g79S:
32.7
6h7mA-6g79S:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
6 / 12 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.76A 6h7mB-6g79S:
33.0
6h7mB-6g79S:
29.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 TRP S 125
TRP S 327
PHE S 330
PHE S 331
TYR S 359
None
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.51A 6iblA-6g79S:
23.9
6iblA-6g79S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo
sapiens)
5 / 12 TRP S 125
TRP S 327
PHE S 330
PHE S 331
TYR S 359
None
None
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
0.55A 6iblB-6g79S:
32.6
6iblB-6g79S:
undetectable