SIMILAR PATTERN OF AMINO ACIDS MAPPED TO 'EOH'


List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1152
ALA A1160
HIS A1188
LEU A1187
ALA A1153
 EOH  A3000 ( 4.9A)
None
None
None
None
 1.04A 1bzfA-1yxoA:
undetectable		 1bzfA-1yxoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3bj6 TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY
(Ruegeria
pomeroyi) 		5 / 11 GLU A  44
ARG A  40
LEU A  48
ALA A  60
GLY A  58
 None
EOH  A 150 ( 4.8A)
None
None
None
 1.26A 1cmaA-3bj6A:
undetectable
1cmaB-3bj6A:
undetectable		 1cmaA-3bj6A:
22.29
1cmaB-3bj6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 ALA A 263
ALA A 288
TRP A 324
LEU A 267
ALA A 264
 None
None
None
None
EOH  A 348 ( 3.9A)
 1.00A 1fm6A-3h4xA:
undetectable		 1fm6A-3h4xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 10 GLY A 283
HIS A 297
THR A 308
ILE A 294
THR A 300
 None
EOH  A 403 ( 4.1A)
None
None
None
 1.47A 1gtfP-1u7nA:
undetectable
1gtfQ-1u7nA:
undetectable		 1gtfP-1u7nA:
14.15
1gtfQ-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 8 GLY A 283
HIS A 297
THR A 308
ILE A 294
THR A 300
 None
EOH  A 403 ( 4.1A)
None
None
None
 1.45A 1gtnP-1u7nA:
undetectable
1gtnQ-1u7nA:
undetectable		 1gtnP-1u7nA:
14.15
1gtnQ-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		5 / 11 HIS A  34
HIS A  37
GLY A 149
ASP A 152
ILE A 178
 EOH  A 292 (-4.3A)
None
None
None
EOH  A 292 ( 4.0A)
 1.11A 1jzsA-3mueA:
undetectable		 1jzsA-3mueA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		5 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
 0.96A 1pg2A-3mueA:
3.6		 1pg2A-3mueA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
 1.06A 1qu2A-3mueA:
4.1		 1qu2A-3mueA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 10 VAL A  21
GLY A  20
THR A 308
VAL A   5
HIS A 297
 None
None
None
None
EOH  A 403 ( 4.1A)
 1.15A 1v3qE-1u7nA:
undetectable		 1v3qE-1u7nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.10A 1zzrA-2nxfA:
undetectable
1zzrB-2nxfA:
undetectable		 1zzrA-2nxfA:
22.70
1zzrB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 1zzrA-2nxfA:
undetectable
1zzrB-2nxfA:
undetectable		 1zzrA-2nxfA:
22.70
1zzrB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.11A 1zzuA-2nxfA:
0.5
1zzuB-2nxfA:
undetectable		 1zzuA-2nxfA:
22.70
1zzuB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.12A 1zzuA-2nxfA:
0.5
1zzuB-2nxfA:
undetectable		 1zzuA-2nxfA:
22.70
1zzuB-2nxfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 7 TYR A 566
GLY A 528
THR A 327
ASN A 525
 None
None
None
EOH  A   1 (-3.6A)
 0.99A 2g70A-3pamA:
undetectable		 2g70A-3pamA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3pam TRANSMEMBRANE
PROTEIN
(Bartonella
henselae) 		4 / 7 TYR A 566
GLY A 528
THR A 327
ASN A 525
 None
None
None
EOH  A   1 (-3.6A)
 0.99A 2g70B-3pamA:
undetectable		 2g70B-3pamA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		4 / 4 LEU A 282
ILE A 245
ILE A 211
ALA A 212
 None
EOH  A 296 (-4.9A)
None
None
 0.79A 2i30A-3mueA:
undetectable		 2i30A-3mueA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 GLY A  66
GLY A  90
GLY A  95
ASP A 155
VAL A 156
 None
EOH  A 301 ( 3.7A)
None
None
None
 0.74A 2oxtA-3hp7A:
14.6		 2oxtA-3hp7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		6 / 12 GLY A  66
ASP A  88
GLY A  90
GLY A  95
ASP A 155
VAL A 156
 None
None
EOH  A 301 ( 3.7A)
None
None
None
 0.73A 2oxtD-3hp7A:
13.3		 2oxtD-3hp7A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		5 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
 0.95A 2x1lA-3mueA:
5.0		 2x1lA-3mueA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		5 / 12 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
 0.90A 2x1lB-3mueA:
4.3		 2x1lB-3mueA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		5 / 11 HIS A  34
GLY A  36
HIS A  37
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
 0.93A 2x1lC-3mueA:
5.5		 2x1lC-3mueA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 8 VAL A 128
GLY A  94
THR A  97
GLY A  90
ALA A  91
 None
None
None
EOH  A 301 ( 3.7A)
None
 1.38A 3aruA-3hp7A:
undetectable		 3aruA-3hp7A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2hyk BETA-1,3-GLUCANASE
(Nocardiopsis
sp.
F96) 		4 / 6 ASN A  51
SER A  52
HIS A  30
ASP A  47
 None
None
EOH  A 246 ( 4.1A)
None
 1.27A 3aruA-2hykA:
undetectable		 3aruA-2hykA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 4 LEU A 301
ASP A  89
VAL A  52
THR A 298
 None
None
EOH  A 502 (-4.7A)
None
 1.29A 3cyxB-2nxfA:
undetectable		 3cyxB-2nxfA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3dqrA-2nxfA:
undetectable
3dqrB-2nxfA:
undetectable		 3dqrA-2nxfA:
22.59
3dqrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 3dqrA-2nxfA:
undetectable
3dqrB-2nxfA:
undetectable		 3dqrA-2nxfA:
22.59
3dqrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 GLU A  64
SER A 104
VAL A 105
 None
EOH  A 300 ( 4.8A)
None
 0.68A 3eeoA-1fy1A:
undetectable		 3eeoA-1fy1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 GLY A  66
GLY A  90
GLY A  95
ASN A 135
ASP A 155
 None
EOH  A 301 ( 3.7A)
None
None
None
 0.44A 3eluA-3hp7A:
14.2		 3eluA-3hp7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 GLY A  66
GLY A  90
GLY A  95
ASN A 135
ASP A 155
 None
EOH  A 301 ( 3.7A)
None
None
None
 0.49A 3elwA-3hp7A:
12.7		 3elwA-3hp7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ult ICE
RECRYSTALLIZATION
INHIBITION
PROTEIN-LIKE PROTEIN
(Lolium
perenne) 		4 / 7 THR A  29
VAL A  46
THR A  44
VAL A  59
 None
EDO  A 134 (-4.2A)
EOH  A 139 ( 4.7A)
None
 0.61A 3em0B-3ultA:
undetectable		 3em0B-3ultA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 GLY A  66
GLY A  90
GLY A  95
ASN A 135
ASP A 155
 None
EOH  A 301 ( 3.7A)
None
None
None
 0.44A 3embA-3hp7A:
14.4		 3embA-3hp7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3a0v SENSOR PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 469
SER A 474
ILE A 514
ARG A 435
LEU A 430
 None
None
None
None
EOH  A 101 ( 4.4A)
 1.37A 3iv6C-3a0vA:
undetectable		 3iv6C-3a0vA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5ej0 ENVELOPE PROTEIN H3
(Vaccinia
virus) 		5 / 12 VAL A  11
HIS A 101
PHE A 110
THR A 194
ARG A 227
 None
None
None
PG0  A 705 (-3.1A)
EOH  A 718 (-4.1A)
 1.32A 3j6pB-5ej0A:
undetectable		 3j6pB-5ej0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.12A 3jx2A-2nxfA:
undetectable
3jx2B-2nxfA:
undetectable		 3jx2A-2nxfA:
22.59
3jx2B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.14A 3jx2A-2nxfA:
undetectable
3jx2B-2nxfA:
undetectable		 3jx2A-2nxfA:
22.59
3jx2B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.10A 3jx3A-2nxfA:
undetectable
3jx3B-2nxfA:
0.2		 3jx3A-2nxfA:
22.59
3jx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 3jx3A-2nxfA:
undetectable
3jx3B-2nxfA:
0.2		 3jx3A-2nxfA:
22.59
3jx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 6 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.14A 3jx4A-2nxfA:
undetectable
3jx4B-2nxfA:
0.4		 3jx4A-2nxfA:
22.59
3jx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.18A 3jx4A-2nxfA:
undetectable
3jx4B-2nxfA:
0.3		 3jx4A-2nxfA:
22.59
3jx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3jx5A-2nxfA:
undetectable
3jx5B-2nxfA:
0.4		 3jx5A-2nxfA:
22.59
3jx5B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.18A 3jx5A-2nxfA:
undetectable
3jx5B-2nxfA:
0.4		 3jx5A-2nxfA:
22.59
3jx5B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.19A 3jx6A-2nxfA:
0.4
3jx6B-2nxfA:
0.4		 3jx6A-2nxfA:
22.59
3jx6B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.16A 3jx6A-2nxfA:
0.4
3jx6B-2nxfA:
0.4		 3jx6A-2nxfA:
22.59
3jx6B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 TYR A 308
LEU A 184
SER A 329
ILE A 171
GLY A 173
 None
EOH  A 573 ( 4.8A)
None
None
None
 1.04A 3kk6A-1j71A:
undetectable		 3kk6A-1j71A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 TYR A 308
LEU A 184
SER A 329
ILE A 171
GLY A 173
 None
EOH  A 573 ( 4.8A)
None
None
None
 1.01A 3kk6B-1j71A:
0.0		 3kk6B-1j71A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.14A 3kkzA-4uhmA:
undetectable		 3kkzA-4uhmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE
(Parabacteroides
distasonis) 		4 / 4 GLY A 298
TYR A 300
GLY A  49
ASP A  77
 EOH  A 402 (-3.4A)
EOH  A 402 (-4.0A)
EOH  A 402 (-4.2A)
EOH  A 402 (-3.8A)
 1.09A 3kl3A-3obeA:
11.4		 3kl3A-3obeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 2bmo OXYGENASE-ALPHA NBDO
(Comamonas
sp.
JS765) 		3 / 3 HIS A 143
PHE A 329
PHE A 311
 EOH  A1446 (-3.5A)
None
None
 0.78A 3lk0D-2bmoA:
0.0		 3lk0D-2bmoA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.16A 3nljA-2nxfA:
0.2
3nljB-2nxfA:
undetectable		 3nljA-2nxfA:
22.59
3nljB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.20A 3nljA-2nxfA:
0.1
3nljB-2nxfA:
undetectable		 3nljA-2nxfA:
22.59
3nljB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.12A 3nlpA-2nxfA:
undetectable
3nlpB-2nxfA:
0.4		 3nlpA-2nxfA:
22.59
3nlpB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.17A 3nlpA-2nxfA:
undetectable
3nlpB-2nxfA:
0.4		 3nlpA-2nxfA:
22.59
3nlpB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 3nlqA-2nxfA:
undetectable
3nlqB-2nxfA:
undetectable		 3nlqA-2nxfA:
22.59
3nlqB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.13A 3nlqA-2nxfA:
undetectable
3nlqB-2nxfA:
undetectable		 3nlqA-2nxfA:
22.59
3nlqB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.12A 3nlrA-2nxfA:
undetectable
3nlrB-2nxfA:
undetectable		 3nlrA-2nxfA:
22.59
3nlrB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 8 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 3nlrA-2nxfA:
undetectable
3nlrB-2nxfA:
undetectable		 3nlrA-2nxfA:
22.59
3nlrB-2nxfA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		7 / 12 ASP A  32
GLY A  34
ASP A 120
ASP A 218
THR A 221
TYR A 225
ILE A 298
 None
None
None
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 0.55A 3prsA-1j71A:
36.5		 3prsA-1j71A:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
THR A 221
TYR A 225
ILE A 298
 None
None
EOH  A 575 (-4.0A)
None
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 0.42A 3prsA-1j71A:
36.5		 3prsA-1j71A:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 ASP A  32
GLY A  85
THR A 221
TYR A 225
ILE A 298
 None
EOH  A 575 (-4.0A)
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 0.34A 3pwwA-1j71A:
36.4		 3pwwA-1j71A:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ASP A  32
GLY A  34
GLY A  85
GLU A 194
ASP A 218
THR A 221
TYR A 225
ILE A 298
 None
None
EOH  A 575 (-4.0A)
None
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 0.49A 3q70A-1j71A:
50.5		 3q70A-1j71A:
62.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A 218
THR A 221
TYR A 225
ILE A 298
 None
None
None
EOH  A 575 (-4.0A)
None
EOH  A 575 ( 4.4A)
EOH  A 575 ( 4.0A)
None
 1.12A 3q70A-1j71A:
50.5		 3q70A-1j71A:
62.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.13A 3sxjA-4uhmA:
undetectable		 3sxjA-4uhmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.14A 3sxjB-4uhmA:
undetectable		 3sxjB-4uhmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.20A 3t7sB-4uhmA:
undetectable		 3t7sB-4uhmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE
(Pseudomonas
sp.) 		5 / 12 GLN A 243
GLY A 201
GLY A 240
ALA A 205
ASN A 206
 None
None
EOH  A1452 (-4.0A)
None
None
 1.18A 3t7sD-4uhmA:
undetectable		 3t7sD-4uhmA:
23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A  86
ASP A 218
TYR A 225
ILE A 298
 None
None
None
EOH  A 575 (-4.0A)
None
None
EOH  A 575 ( 4.0A)
None
 0.46A 3tneA-1j71A:
49.5		 3tneA-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 GLY A  34
ILE A  82
GLY A  85
ASP A  86
ASP A 120
ASP A 218
TYR A 225
ILE A 298
 None
None
EOH  A 575 (-4.0A)
None
None
None
EOH  A 575 ( 4.0A)
None
 0.77A 3tneA-1j71A:
49.5		 3tneA-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 218
TYR A 225
ILE A 298
 None
None
None
EOH  A 575 (-4.0A)
None
None
EOH  A 575 ( 4.0A)
None
 1.16A 3tneA-1j71A:
49.5		 3tneA-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ILE A 123
GLY A  34
GLY A  85
ASP A  86
ASP A 120
ASP A 218
TYR A 225
ILE A 298
 None
None
EOH  A 575 (-4.0A)
None
None
None
EOH  A 575 ( 4.0A)
None
 1.36A 3tneA-1j71A:
49.5		 3tneA-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		6 / 6 PRO A  12
SER A  35
TYR A  84
VAL A 119
THR A 221
THR A 222
 None
None
None
None
EOH  A 575 ( 4.4A)
None
 0.30A 3tneA-1j71A:
49.5		 3tneA-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ASP A  32
GLY A  34
ILE A  82
GLY A  85
ASP A  86
ASP A 120
ASP A 218
ILE A 298
 None
None
None
EOH  A 575 (-4.0A)
None
None
None
None
 0.72A 3tneB-1j71A:
49.5		 3tneB-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		8 / 12 ILE A 123
ASP A  32
GLY A  34
GLY A  85
ASP A  86
ASP A 120
ASP A 218
ILE A 298
 None
None
None
EOH  A 575 (-4.0A)
None
None
None
None
 1.38A 3tneB-1j71A:
49.5		 3tneB-1j71A:
54.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		7 / 7 SER A  35
TYR A  84
VAL A 119
ILE A 123
THR A 221
THR A 222
TYR A 225
 None
None
None
None
EOH  A 575 ( 4.4A)
None
EOH  A 575 ( 4.0A)
 0.51A 3tneB-1j71A:
49.5		 3tneB-1j71A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.04A 3u9fF-1f8fA:
0.0		 3u9fF-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.10A 3u9fG-1f8fA:
0.0		 3u9fG-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.10A 3u9fL-1f8fA:
0.0		 3u9fL-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.04A 3u9fS-1f8fA:
0.0		 3u9fS-1f8fA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		6 / 8 GLN A  61
ARG A 123
HIS A 126
VAL A 130
ASP A 152
GLN A 155
 GOL  A 291 ( 2.9A)
EOH  A 298 (-3.8A)
EOH  A 298 (-4.6A)
GOL  A 291 ( 4.3A)
None
GOL  A 291 (-3.4A)
 0.67A 3uy4A-3mueA:
31.1		 3uy4A-3mueA:
42.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 TYR A  13
TYR A  57
ARG A  48
LEU A  44
 None
EOH  A 303 (-2.7A)
EOH  A 303 ( 3.8A)
None
 1.29A 3wipG-5kivA:
undetectable
3wipH-5kivA:
undetectable		 3wipG-5kivA:
20.59
3wipH-5kivA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		3 / 3 ARG A 203
PHE A 207
PRO A 208
 EOH  A 257 (-3.3A)
ACT  A 256 ( 4.9A)
None
 0.62A 3zoaB-3iahA:
undetectable		 3zoaB-3iahA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 LEU A 251
LEU A 263
LEU A 266
VAL A 239
THR A 249
 None
EOH  A 403 (-3.9A)
EOH  A 403 (-4.0A)
None
None
 1.39A 3zqtA-2pl3A:
undetectable		 3zqtA-2pl3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		6 / 12 SER A  64
GLY A  90
GLY A  94
GLY A  95
ASP A 112
ASP A 155
 None
EOH  A 301 ( 3.7A)
None
None
EOH  A 301 (-4.0A)
None
 0.57A 4b17A-3hp7A:
16.9		 4b17A-3hp7A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ARG A  73
LEU A  63
ARG A 140
GLY A 106
 None
None
GOL  A 366 ( 3.6A)
EOH  A 349 (-3.7A)
 0.88A 4cp3A-3h4xA:
undetectable
4cp3B-3h4xA:
undetectable		 4cp3A-3h4xA:
15.29
4cp3B-3h4xA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 SER A  64
GLY A  66
GLY A  90
GLY A  95
ASP A 155
 None
None
EOH  A 301 ( 3.7A)
None
None
 0.76A 4ctkC-3hp7A:
13.8		 4ctkC-3hp7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.08A 4cx3A-2nxfA:
0.4
4cx3B-2nxfA:
undetectable		 4cx3A-2nxfA:
22.59
4cx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.12A 4cx3A-2nxfA:
0.4
4cx3B-2nxfA:
undetectable		 4cx3A-2nxfA:
22.59
4cx3B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.08A 4cx4A-2nxfA:
undetectable
4cx4B-2nxfA:
undetectable		 4cx4A-2nxfA:
22.59
4cx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.11A 4cx4A-2nxfA:
undetectable
4cx4B-2nxfA:
undetectable		 4cx4A-2nxfA:
22.59
4cx4B-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 ALA A 234
GLU A 192
HIS A 236
TYR A 247
ARG A 246
 None
None
EOH  A 358 (-4.0A)
None
None
 1.37A 4ejwA-3h4xA:
undetectable		 4ejwA-3h4xA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.82A 4feuB-3h4xA:
undetectable		 4feuB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.90A 4feuD-3h4xA:
undetectable		 4feuD-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.85A 4feuF-3h4xA:
undetectable		 4feuF-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.89A 4fevB-3h4xA:
undetectable		 4fevB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
GLU A  41
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 1.04A 4fevB-3h4xA:
undetectable		 4fevB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4fevD-3h4xA:
undetectable		 4fevD-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4fevF-3h4xA:
undetectable		 4fevF-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.90A 4fewB-3h4xA:
undetectable		 4fewB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
GLU A  41
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.96A 4fewB-3h4xA:
undetectable		 4fewB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4fewD-3h4xA:
undetectable		 4fewD-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4fewF-3h4xA:
undetectable		 4fewF-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.91A 4fexB-3h4xA:
undetectable		 4fexB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.89A 4gkhB-3h4xA:
undetectable		 4gkhB-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.89A 4gkhD-3h4xA:
undetectable		 4gkhD-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
GLU A  41
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.97A 4gkhD-3h4xA:
undetectable		 4gkhD-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4gkhF-3h4xA:
undetectable		 4gkhF-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.86A 4gkhG-3h4xA:
undetectable		 4gkhG-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 6 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.91A 4gkhJ-3h4xA:
undetectable		 4gkhJ-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.88A 4gkhC-3h4xA:
undetectable
4gkhK-3h4xA:
undetectable		 4gkhC-3h4xA:
21.59
4gkhK-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.86A 4gkiA-3h4xA:
undetectable		 4gkiA-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4gkiC-3h4xA:
undetectable		 4gkiC-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 8 ASP A  62
ASP A 287
ASN A  38
GLU A 129
 None
EOH  A 348 ( 4.5A)
None
None
 0.87A 4gkiE-3h4xA:
undetectable
4gkiG-3h4xA:
undetectable		 4gkiE-3h4xA:
21.59
4gkiG-3h4xA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens) 		5 / 12 VAL A 195
VAL A 220
ALA A 224
GLU A 223
LEU A 153
 None
None
None
MG  A 301 ( 3.0A)
EOH  A 400 (-4.7A)
 1.06A 4i1rA-2pl3A:
undetectable		 4i1rA-2pl3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3a0v SENSOR PROTEIN
(Thermotoga
maritima) 		4 / 8 VAL A 475
VAL A 512
ILE A 514
LEU A 484
 None
EOH  A 101 ( 4.7A)
None
None
 0.92A 4jq1B-3a0vA:
undetectable		 4jq1B-3a0vA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2bmo OXYGENASE-ALPHA NBDO
(Comamonas
sp.
JS765) 		5 / 9 TRP A 252
ALA A 405
LEU A 238
GLY A 402
ALA A 279
 EOH  A1449 ( 4.1A)
None
None
None
None
 1.46A 4l6va-2bmoA:
undetectable
4l6vf-2bmoA:
0.0		 4l6va-2bmoA:
21.68
4l6vf-2bmoA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		3 / 3 ASP A 210
TYR A 247
TRP A 208
 None
None
EOH  A 347 (-3.5A)
 1.32A 4p7nA-3h4xA:
6.4		 4p7nA-3h4xA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 ASP A 112
SER A  64
GLY A  90
ASP A 155
LYS A  69
 EOH  A 301 (-4.0A)
None
EOH  A 301 ( 3.7A)
None
None
 1.11A 4pevB-3hp7A:
undetectable		 4pevB-3hp7A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 9 ALA A 263
ILE A 194
ASP A 262
GLY A 237
ALA A 238
 None
None
EOH  A 348 ( 2.5A)
None
None
 1.20A 4r1zA-3h4xA:
undetectable		 4r1zA-3h4xA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		3 / 3 SER A 329
ASP A 312
ASP A   2
 None
EOH  A 573 ( 4.5A)
None
 0.77A 4uckA-1j71A:
undetectable		 4uckA-1j71A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE
(Parabacteroides
distasonis) 		4 / 8 GLY A  56
GLN A  57
TYR A  93
PHE A  81
 EOH  A 405 ( 4.7A)
None
None
EOH  A 406 (-3.9A)
 1.03A 4wryA-3obeA:
undetectable		 4wryA-3obeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE
(Parabacteroides
distasonis) 		4 / 8 GLY A  56
GLN A  57
TYR A  93
PHE A  81
 EOH  A 405 ( 4.7A)
None
None
EOH  A 406 (-3.9A)
 1.03A 4wrzA-3obeA:
undetectable		 4wrzA-3obeA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1xx5 NATRIN 1
(Naja
atra) 		4 / 7 GLY A 114
TYR A 147
ASN A 152
HIS A 115
 EOH  A 501 ( 3.7A)
None
None
EOH  A 501 ( 4.0A)
 1.18A 4ws0A-1xx5A:
undetectable		 4ws0A-1xx5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 145
 None
None
None
EOH  A 572 ( 4.2A)
None
 0.87A 4y8wA-1j71A:
undetectable		 4y8wA-1j71A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 145
 None
None
None
EOH  A 572 ( 4.2A)
None
 0.88A 4y8wB-1j71A:
undetectable		 4y8wB-1j71A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 VAL A  29
ILE A  18
GLY A 100
VAL A   3
LEU A 145
 None
None
None
EOH  A 572 ( 4.2A)
None
 0.87A 4y8wC-1j71A:
0.0		 4y8wC-1j71A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 11 THR A1099
SER A1037
ALA A1081
GLU A1011
GLY A1016
 None
EOH  A3007 ( 4.8A)
None
None
None
 1.24A 4zjoD-1yxoA:
undetectable		 4zjoD-1yxoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 6 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 5addA-2nxfA:
undetectable
5addB-2nxfA:
undetectable		 5addA-2nxfA:
22.59
5addB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.15A 5addA-2nxfA:
undetectable
5addB-2nxfA:
undetectable		 5addA-2nxfA:
22.59
5addB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 6 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.22A 5adeA-2nxfA:
undetectable
5adeB-2nxfA:
undetectable		 5adeA-2nxfA:
22.59
5adeB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.24A 5adeA-2nxfA:
undetectable
5adeB-2nxfA:
undetectable		 5adeA-2nxfA:
22.59
5adeB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 6 ILE A 194
VAL A 258
ASP A 260
ALA A 234
 None
None
EOH  A 358 (-4.1A)
None
 0.50A 5cu6A-3h4xA:
undetectable		 5cu6A-3h4xA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 SER A  64
GLY A  66
GLY A  90
GLY A  95
ASP A 155
 None
None
EOH  A 301 ( 3.7A)
None
None
 0.73A 5ec8A-3hp7A:
13.9		 5ec8A-3hp7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eeuB-1u7nA:
undetectable
5eeuC-1u7nA:
undetectable		 5eeuB-1u7nA:
14.15
5eeuC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eevB-1u7nA:
undetectable
5eevC-1u7nA:
undetectable		 5eevB-1u7nA:
14.15
5eevC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eexB-1u7nA:
undetectable
5eexC-1u7nA:
undetectable		 5eexB-1u7nA:
14.15
5eexC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.48A 5eeyB-1u7nA:
undetectable
5eeyC-1u7nA:
0.0		 5eeyB-1u7nA:
14.15
5eeyC-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.47A 5ef0B-1u7nA:
undetectable
5ef0C-1u7nA:
0.0		 5ef0B-1u7nA:
14.15
5ef0C-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.47A 5ef2B-1u7nA:
undetectable
5ef2C-1u7nA:
undetectable		 5ef2B-1u7nA:
14.15
5ef2C-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX
(Enterococcus
faecalis) 		5 / 9 THR A 300
GLY A 283
HIS A 297
THR A 308
ILE A 294
 None
None
EOH  A 403 ( 4.1A)
None
None
 1.47A 5ef3B-1u7nA:
undetectable
5ef3C-1u7nA:
undetectable		 5ef3B-1u7nA:
14.15
5ef3C-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3hp7 HEMOLYSIN, PUTATIVE
(Streptococcus
thermophilus) 		5 / 12 SER A  64
GLY A  66
GLY A  90
GLY A  95
ASP A 155
 None
None
EOH  A 301 ( 3.7A)
None
None
 0.74A 5ekxA-3hp7A:
14.0		 5ekxA-3hp7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 VAL A  52
ARG A 311
VAL A  44
PHE A 296
 EOH  A 502 (-4.7A)
None
None
None
 1.13A 5g0pA-2nxfA:
undetectable
5g0pB-2nxfA:
undetectable		 5g0pA-2nxfA:
22.59
5g0pB-2nxfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2nxf PUTATIVE DIMETAL
PHOSPHATASE
(Danio
rerio) 		4 / 7 PHE A 296
VAL A  52
ARG A 311
VAL A  44
 None
EOH  A 502 (-4.7A)
None
None
 1.16A 5g0pA-2nxfA:
undetectable
5g0pB-2nxfA:
undetectable		 5g0pA-2nxfA:
22.59
5g0pB-2nxfA:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		7 / 12 HIS A  34
GLY A  36
LEU A  40
GLN A  61
TYR A  71
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
GOL  A 291 ( 2.9A)
None
None
None
 0.51A 5hg0A-3mueA:
26.4		 5hg0A-3mueA:
38.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		6 / 12 HIS A  34
GLY A  36
LEU A  40
GLY A 149
LYS A 151
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
None
 0.57A 5hg0A-3mueA:
26.4		 5hg0A-3mueA:
38.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		7 / 12 HIS A  34
GLY A  36
HIS A  37
LEU A  40
GLY A 149
LYS A 151
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
None
None
 0.67A 5hg0B-3mueA:
26.4		 5hg0B-3mueA:
38.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		7 / 12 HIS A  34
GLY A  36
HIS A  37
LEU A  40
TYR A  71
GLY A 149
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
None
None
 0.46A 5hg0B-3mueA:
26.4		 5hg0B-3mueA:
38.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3mue PANTOTHENATE
SYNTHETASE
(Salmonella
enterica) 		6 / 12 HIS A  34
GLY A  36
HIS A  37
VAL A 134
LYS A 151
ASP A 152
 EOH  A 292 (-4.3A)
EOH  A 292 ( 4.1A)
None
None
None
None
 1.40A 5hg0B-3mueA:
26.4		 5hg0B-3mueA:
38.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		5 / 12 VAL A 310
ALA A 155
THR A   5
LYS A 153
ILE A 151
 EOH  A 573 (-4.6A)
None
None
None
None
 1.39A 5hgcA-1j71A:
0.0		 5hgcA-1j71A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 1j71 ASPARTIC PROTEINASE
(Candida
tropicalis) 		4 / 8 ASN A 297
TRP A 242
PHE A 234
THR A 221
 None
None
None
EOH  A 575 ( 4.4A)
 1.45A 5hqaA-1j71A:
undetectable		 5hqaA-1j71A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1fy1 HEPARIN-BINDING
PROTEIN
(Homo
sapiens) 		4 / 5 SER A  17
VAL A  54
GLY A  56
ALA A  57
 None
None
EOH  A 300 (-4.8A)
None
 1.08A 5k50A-1fy1A:
0.0		 5k50A-1fy1A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 HIS A 216
ASP A 146
THR A 230
GLY A 215
PHE A 134
 EOH  A 353 (-3.9A)
None
None
None
None
 1.37A 5m5kB-3h4xA:
undetectable		 5m5kB-3h4xA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE
(Parabacteroides
distasonis) 		5 / 10 LEU A 268
ILE A 296
GLY A 298
VAL A 329
ALA A 291
 None
None
EOH  A 402 (-3.4A)
None
None
 1.03A 5o96C-3obeA:
undetectable
5o96D-3obeA:
undetectable		 5o96C-3obeA:
24.63
5o96D-3obeA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ILE A 194
VAL A 258
ASP A 260
ALA A 234
 None
None
EOH  A 358 (-4.1A)
None
 0.48A 5ospA-3h4xA:
undetectable		 5ospA-3h4xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		4 / 7 ILE A 194
VAL A 258
ASP A 260
ALA A 234
 None
None
EOH  A 358 (-4.1A)
None
 0.45A 5osrA-3h4xA:
undetectable		 5osrA-3h4xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1l9l GRANULYSIN
(Homo
sapiens) 		3 / 3 ILE A  57
VAL A  26
PRO A  21
 None
None
EOH  A 101 ( 4.2A)
 0.71A 5uunA-1l9lA:
undetectable		 5uunA-1l9lA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3uzv ANTI-DENGUE MAB 4E11
ENVELOPE PROTEIN
(Dengue
virus;
Mus
musculus) 		4 / 7 THR B  33
ARG A 323
ARG B  99
SER A 331
 EOH  B 254 (-3.2A)
None
None
None
 1.28A 5uxcA-3uzvB:
undetectable		 5uxcA-3uzvB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4ofg CGMP-DEPENDENT
PROTEIN KINASE
(Plasmodium
falciparum) 		3 / 3 TYR A 417
HIS A 524
MET A 521
 SO4  A 609 ( 4.3A)
SO4  A 609 (-3.5A)
EOH  A 611 ( 4.5A)
 1.10A 6af6A-4ofgA:
undetectable		 6af6A-4ofgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 HIS A 216
ASP A 146
LEU A 220
GLY A 215
PHE A 134
 EOH  A 353 (-3.9A)
None
None
None
None
 1.41A 6f3mA-3h4xA:
undetectable		 6f3mA-3h4xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 HIS A 216
ASP A 146
LEU A 220
GLY A 215
PHE A 134
 EOH  A 353 (-3.9A)
None
None
None
None
 1.41A 6f3mC-3h4xA:
undetectable		 6f3mC-3h4xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 HIS A 216
ASP A 146
LEU A 220
GLY A 215
PHE A 134
 EOH  A 353 (-3.9A)
None
None
None
None
 1.45A 6f3nA-3h4xA:
undetectable		 6f3nA-3h4xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 HIS A 216
ASP A 146
LEU A 220
GLY A 215
PHE A 134
 EOH  A 353 (-3.9A)
None
None
None
None
 1.44A 6f3nC-3h4xA:
undetectable		 6f3nC-3h4xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 HIS A 216
ASP A 146
LEU A 220
GLY A 215
PHE A 134
 EOH  A 353 (-3.9A)
None
None
None
None
 1.46A 6f3nD-3h4xA:
undetectable		 6f3nD-3h4xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 HIS A  70
ASN A  69
LEU A  68
 None
None
EOH  A 305 ( 3.4A)
 0.87A 6f7lB-5kivA:
undetectable		 6f7lB-5kivA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 ASP A 287
HIS A 289
GLU A  41
GLU A 129
GLY A 196
 EOH  A 348 ( 4.5A)
None
None
None
None
 1.43A 6gnfC-3h4xA:
undetectable		 6gnfC-3h4xA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1
(Streptomyces
antibioticus) 		5 / 12 THR A 209
GLY A 133
GLY A 237
ASP A 260
ASP A  62
 None
None
None
EOH  A 358 (-4.1A)
None
 1.14A 6gngA-3h4xA:
undetectable		 6gngA-3h4xA:
23.37